Schistosomiasis is an often-neglected tropical disease caused by blood flukes (helminths). The World Health Organization estimates that over 250 million people require preventive treatment for schisto...
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UW-Madison researchers in collaboration with a researcher at Clemson University have developed a chemical scaffold that potently inhibits whole Naegleria fowleri parasites in culture. They have prepar...
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UW-Madison researchers have developed a multi-functional antibiotic nanoparticle that incorporates hemoglobin and the clinically approved antifungal agent naftifine in the core which is coated with re...
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UW Madison researchers and collaborators present a method of treating COVID-19 with lipid- peptide fusion antiviral therapy. Also described is a composition and method of treating Ebola with lipid-pep...
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The present invention from UW Madison inventors and collaborators is a set of two distinct small molecule scaffolds that have been developed as antiviral agents against Venezuelan Equine Encephalitic ...
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The present technology from UW-Madison researchers provides siderophore-polymer conjugates that enhance the sensitivity of bacteria to antibiotics, e.g., Pseudomonas, P. aeruginosa, Acinetobacter, and...
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UW-Madison researchers have developed a method to optimize the production of reuterin in bacterial cells that contain the reuterin production pathway (i.e., the pdu operon). The inventors compared the...
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The present invention from UW-Madison researchers is a small molecule antifungal agent isolated from a bacterial species found in the sea squirt Ecteinascidia turbinate. The inventors collected the sp...
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The present invention from UW-Madison researchers is a set of analogs of turbinmicin that show similar efficacy but are more soluble than the parent molecule. The parent molecule proved to be fairly i...
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UW Madison researchers have developed RhlR modulators including agonist and antagonists which are useful for modulating QS phenotypes in Gram-negative bacteria. Certain compounds of general formula A-...
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UW-Madison researchers have developed methods for preparing PTP1b-deficient neutrophils, which exhibit improved recruitment and antimicrobial functions. The inventors employed CRISPR/Cas9 to delete PT...
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The present invention relates to a ‘sugar fermentate of edible fungi’ (i.e., cultures of GRAS species from the genus Aspergillus) that exhibits antimicrobial activity (e.g., against Listeria monoc...
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UW-Madison researchers have developed a dendron-micelle (DM) nanoparticle platform that can be used for combination therapy in the treatment of interstitial lung disease (ILD), including idiopathic pu...
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UW-Madison researchers have developed methods for generating SIRPα-KO macrophages with superior anti-tumor activity, and SIRPα-knockout neutrophils with superior anti-bacterial and anti-tumor activi...
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UW Madison researchers and collaborators have developed anti-SARS-CoV-2 α/β-polypeptides, pharmaceutical compositions containing the same, and methods to inhibit, treat, and ameliorate SARS...
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The present invention from UW Madison inventors is a set of analogs of turbinmicin that show similar efficacy but are more soluble than the parent molecule. The parent molecule proved to be fairly ins...
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The present technology from UW Madison innovators provides a system for monitoring quorum-sensing in bacteria comprising bacteria that release at least one membrane-lytic toxin when the bacteria are a...
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The present technology from this UW Madison researcher is a germinant mixture that includes a) a bile acid main germinant, b) an amino acid co-germinant, c) an edible spore solubilizing agent, and d) ...
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UW-Madison researchers have isolated and characterized a BA.2 strain of the Omicron variant of SARS-CoV-2.
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UW-Madison researchers have isolated and characterized a BA.1 strain of the Omicron variant of SARS-CoV-2.
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UW Madison researchers have provided herein biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacter...
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Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.
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Ebola Virus Disease (EVD) is a severe and highly fatal hemorrhagic fever that affects humans and other mammals. It is caused by the Ebola virus, a single-stranded RNA virus that encodes seven structur...
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Every year worldwide, millions of people experience morbidity and mortality as a consequence of severe fungal disease. In the United States, mortality from invasive fungal disease is approximately 50 ...
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Provided herein are polymer-drug conjugates with enhanced antibacterial efficacy. These conjugates include a polymer comprising a plurality of masked cationic functional groups and an antibiotic drug ...
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