Wisconsin Alumni Research Foundation

Technology

Inhibitors Of Bacterial Pasta Kinases

Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.
Learn More
Robert Striker, Nathan Wlodarchak, John Feltenberger, Jennifer Golden | P180315US02

Technology

Drugs To Prevent Hpv Infection

A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Com...
Learn More
Paul Lambert, Paul Ahlquist, Dohun Pyeon, Hao-Shun Huang | P08406US02

Technology

Anti-microbial Agents

Antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The antimicrobial agents comprise conjugatively transmissible plasmids that kill targeted ...
Learn More
Marcin Filutowicz | P04023US

Technology

Antifungal Compounds

Compounds of formula (I) or formula (II), compositions and methods useful for treating and/or preventing a fungal infections are provided. wherein the substituents are as defined in the appended claim...
Learn More
Cameron Currie, Ethan Van Amam, Clarissa Sit, Antonio Ruzzini, Jon Clardy, Adrian Pinto-Tomas | P170089US03

Technology

Cyphomycin, Compositions And Uses Thereof

Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cypho...
Learn More
Cameron Currie, Timothy Bugni, Monica Pupo, David Andes, Humberto Ortega Dominguez | P180334US02

Technology

Novel Small Molecule SIRT6 Activators/Inhibitors

The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
Learn More
John Denu, Weiping Tang | P160306US01

Technology

Natural Antibiotic to Treat Clostridium Infection and More

Bacterial resistance to antibiotics is an escalating problem, especially in hospital settings. The Centers for Disease Control recently identified Clostridium difficile as posing an “urgent” healt...
Learn More
Timothy Bugni, Thomas Wyche, Douglas Braun, Jeff Piotrowski, Nasia Safdar | P140428US02

Technology

Nylon-3 Polymers to Treat Fungal Infections

Invasive fungal infections pose a growing threat, causing an estimated 1.5 million deaths each year worldwide. Ninety percent of the deaths are caused by one of four genera: Cryptococcus, Candida, Asp...
Learn More
Samuel Gellman, Runhui Liu, Bernard Weisblum, Fang Yun Lim, Nancy Keller, Jin Woo Bok, Christina Hull, Naomi Walsh, Leslie Rank, Mingwei Huang | P170021US02

Technology

Compound Combination Targets Bacterial Virulence

Many common bacterial pathogens delay virulence factor production until there is a sufficient number of cells that – working together – can overwhelm a host’s defense. To coordinate such...
Learn More
Helen Blackwell, Michael Welsh | P160176US02

Technology

Nylon-3 Polymers Active Against Clostridium Difficile

Clostridium difficile is a Gram-positive, endospore-forming anaerobe that causes life-threatening intestinal infections. These infections result in more than 14,000 deaths and billions of dollars in h...
Learn More
Samuel Gellman, Runhui Liu, Bernard Weisblum, Shonna McBride | P150214US02

WARF