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47 Results for 'Anti-infectives (antibacterials, antifungals, antivirals)'
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Technology
Compositions And Methods Of Clostridiodides Difficile Treatment, Decolonization, And Prevention
The present technology from this UW Madison researcher is a germinant mixture that includes a) a bile acid main germinant, b) an amino acid co-germinant, c) an edible spore solubilizing agent, and d) ...
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Noah Budi | P210282US02
Technology
SARS-COV-2 OMICRON BA.2 VARIANT FOR MEDICAL COUNTERMEASURE EVALUATION
UW-Madison researchers have isolated and characterized a BA.2 strain of the Omicron variant of SARS-CoV-2.
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Yoshihiro Kawaoka | P220198US01
Technology
SARS-COV-2 BA.1 OMICRON VARIANT FOR MEDICAL COUNTERMEASURE EVALUATION
UW-Madison researchers have isolated and characterized a BA.1 strain of the Omicron variant of SARS-CoV-2.
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Yoshihiro Kawaoka, Peter Halfmann | P220159US01
Technology
Dual-Responsive Nanoparticles For Enhanced Antibacterial Efficacy
UW Madison researchers have provided herein biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacter...
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Shaoqin Gong, Mingzhou Ye, David Andes | P210016US02
Technology
Inhibitors Of Bacterial Pasta Kinases
Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.
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Robert Striker, Nathan Wlodarchak, John Feltenberger, Jennifer Golden | P180315US02
Technology
Generation of Wild Type and Mutant Ebola Virus from Cloned cDNA
Ebola Virus Disease (EVD) is a severe and highly fatal hemorrhagic fever that affects humans and other mammals. It is caused by the Ebola virus, a single-stranded RNA virus that encodes seven structur...
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Yoshihiro Kawaoka, Gabriele Neumann, Luke Jasenosky | P01214US02
Technology
Methods to Screen Antifungal Compounds and Treat Fungal Diseases by Inhibiting Spore Germination
Every year worldwide, millions of people experience morbidity and mortality as a consequence of severe fungal disease. In the United States, mortality from invasive fungal disease is approximately 50 ...
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Christina Hull, Mingwei Huang, Sébastien Ortiz | P180117US02
Technology
Ph-Responsive Polymer–Antibiotic Conjugate For Enhanced Antimicrobial Efficacy
Provided herein are polymer-drug conjugates with enhanced antibacterial efficacy. These conjugates include a polymer comprising a plurality of masked cationic functional groups and an antibiotic drug ...
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Shaoqin Gong, Mingzhou Ye | P200087US02
Technology
Drugs To Prevent Hpv Infection
A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Com...
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Paul Lambert, Paul Ahlquist, Dohun Pyeon, Hao-Shun Huang | P08406US02
Technology
High Titer Recombinant Influenza Viruses With Enhanced Replication In Mdck Or Vero Cells Or Eggs
The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isola...
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Yoshihiro Kawaoka, Gabriele Neumann, Jihui Ping | P130287US02
Technology
Anti-microbial Agents
Antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The antimicrobial agents comprise conjugatively transmissible plasmids that kill targeted ...
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Marcin Filutowicz | P04023US
Technology
Reversible Natural Product Glycosyltransferase-catalyzed Reactions, Compounds And Related Methods
The present invention relates to methods of use of glycosyltransferases and related compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomol...
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Jon Thorson, Byron Griffith, Changsheng Zhang | P06427US
Technology
Simplified Structural Mimetics Of Aips As Quorum Sensing Inhibitors
Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or m...
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Helen Blackwell, Joseph Vasquez, Yiftah Tal Gan | P170030US02
Technology
Circular Strained Zymogen Compositions And Methods Of Use
Disclosed herein are circular zymogens of RNase 1 that have a proteolytic cleavage site and are activated by a specific protease. These circular zymogens are useful for treatment of disorders that are...
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Ronald Raines, Ian Windsor | P190190US02
Technology
Antifungal Compounds
Compounds of formula (I) or formula (II), compositions and methods useful for treating and/or preventing a fungal infections are provided. wherein the substituents are as defined in the appended claim...
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Cameron Currie, Ethan Van Amam, Clarissa Sit, Antonio Ruzzini, Jon Clardy, Adrian Pinto-Tomas | P170089US03
Technology
Use Of A Rotifer-Derived Compound And Its Analogs For Preventing Schistosomiasis
The present disclosure relates provides compounds according to Formula I or Formula II as well as compositions including such compounds useful for the prevention of schistosomiasis infection and/or sw...
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Phillip Newmark, Jonathan Sweedler, Ning Yang, Jiarong Gao, Peter Yau | P180311US02
Technology
Cyphomycin, Compositions And Uses Thereof
Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cypho...
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Cameron Currie, Timothy Bugni, Monica Pupo, David Andes, Humberto Ortega Dominguez | P180334US02
Technology
An Ionic Liquid-Based Nanoemulsion Formulation For The Efficient Delivery Of Hydrophobic Therapeutic Agents
The present invention discloses an ionic liquid composition comprising an at least partially hydrophobic ionic liquid, wherein the at least partially hydrophobic ionic liquid comprises a dication comp...
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Sandro Mecozzi, Moira Esson | P180283US02
Technology
A Novel Series of Antimicrobials Target Bacteria Membranes to Overcome Antibiotic Resistance
Drug resistant pathogens continue to emerge as the rate of the development of new antimicrobials to combat them continues to decline. Alarmingly, slow-growing bacteria associated with dangerous and pr...
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Douglas Weibel, Ye Jin Eun, Marie Foss, Katherine Hurley | P120204US02
Technology
Inhibiting Quorum Sensing in Staphylococcus Epidermidis, a Health Care Pathogen
Staphylococcus epidermidis is an important Gram-negative bacterial pathogen in hospital-acquired infections, and the most common cause of infections on indwelling medical devices. The costs related to...
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Helen Blackwell, Tian Yang | P150348US02
Technology
Novel Small Molecule SIRT6 Activators/Inhibitors
The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
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John Denu, Weiping Tang | P160306US01
Technology
Natural Antibiotic to Treat Clostridium Infection and More
Bacterial resistance to antibiotics is an escalating problem, especially in hospital settings. The Centers for Disease Control recently identified Clostridium difficile as posing an “urgent” healt...
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Timothy Bugni, Thomas Wyche, Douglas Braun, Jeff Piotrowski, Nasia Safdar | P140428US02
Technology
Novel Analogs of Podophyllotoxin May Treat Cancer and Viral Infections
Podophyllotoxin is a natural product derived from a plant. Although two clinically useful glycosylated analogs have been developed for treating cancer, podophyllotoxin is difficult to synthesize, hind...
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Jon Thorson, James Watson, Jr. | P08343US
Technology
Compound Combination Targets Bacterial Virulence
Many common bacterial pathogens delay virulence factor production until there is a sufficient number of cells that – working together – can overwhelm a host’s defense. To coordinate such...
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Helen Blackwell, Michael Welsh | P160176US02
Technology
Enhanced HIV Treatments: Boronic Acid Group Improves Drug Potency
HIV infection, AIDS and AIDS-related complex (ARC) remain serious and ongoing diseases compromising the human immune system. Protease inhibitors, which interfere with the replication cycle of HIV, are...
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Ronald Raines, Ian Windsor, Michael Palte, John Lukesh | P140376US02