The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2′ and/or the 5′-hydroxy functionalities of the ribose moiety. Said monomers may be incorpo...
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Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell ...
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Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiatio...
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The substrate on which cells are cultured is key to successful growth and tissue generation. For example, it has been shown that attachment to a substrate by human embryonic stem cells influences whet...
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While extensive research has been devoted to understanding the influence of medium conditions on cell development, researchers have only recently begun to understand the role of culture surface proper...
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While extensive research has been devoted to understanding the influence of medium conditions on cell development, researchers have only recently begun to understand the role of culture surface proper...
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The ability to chemically synthesize single-stranded oligonucleotides has had a profound impact on research and medicine. Yet existing strategies have their limitations. One critical limitation is the...
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How and why precursor cells differentiate into tissue-specific cell types involves a complex interplay of signals and remains a rich topic of investigation. Outside of the body, for example, certain s...
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DNA microarrays, or “chips,” are fabricated by high speed robotics on glass or sometimes nylon substrates. During the process of manufacturing DNA microarrays and synthetic DNA strands, an image i...
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A DNA microarray is a collection of microscopic DNA spots arranged on a solid surface via covalent attachment to a chemically suitable substrate. DNA microarrays allow hundreds of thousands of DNA seq...
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Many applications exist for devices that can deposit tiny volumes of fluids, including flexible electronics and biological microarrays. One of these methods uses quill pins (limited to creating 75-mic...
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Before DNA or proteins can be attached to a surface during the making of microarrays, the surface must be functionalized, i.e., chemically prepared to carry functional groups capable of...
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Because conventional DNA sequencing using electrophoresis is laborious and time consuming, alternative approaches, such as those using microarrays, have been developed. Photolithographic techniques ar...
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Bioactive surfaces created by binding biomolecules to the surface of inorganic substrates are used in many bioassays, biosensors, and other devices. One common approach to functionalizing surfaces so ...
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Functionalized substrates have commercial applications ranging from biosensors to energy conversion devices such as solar cells.  Biosensors rapidly detect the presence of target biomolecules bas...
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