Wisconsin Alumni Research Foundation

Technology

Wis.L Master Cell Bank for Vaccine Development

FDA-qualified cell lines must be used for virus production for human vaccines. There are relatively few of these lines available and several (WI-38, MRC-5) used for virus production are becoming senes...
Learn More
James Gern | P160170US01

Technology

Bovine Macrophage Cell Line

Macrophages are white blood cells that ingest foreign material and play a crucial role in the immune system. Presently, there is no bovine macrophage cell line available for research and testing purpo...
Learn More
Charles Czuprynski, Dhammika Atapattu, Josely Figueiredo | P140060US01

Technology

Adapted Rhinovirus C for Maximum Virus Yield

Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
Learn More
James Gern, Yury Bochkov, Ann Palmenberg, Kelly Watters | P160050US02

Technology

Common Variants of the Sodium Channel Alpha Subunits

The SCN5A gene encodes a human cardiac sodium (Na+) channel alpha subunit that carries the inward Na+ current in the heart. Three distinct polymorphic SCN5A clones, hH1, hH1a and hH1b, have been isola...
Learn More
Jonathan Makielski, Bin Ye, Michael Ackerman | P02284US

Technology

HERG CDNA with Native PolyA Tail

The human ERG gene encodes a potassium channel that is expressed in the heart. Mutations in the HERG channel are a common cause of long QT syndrome, a disorder associated with delayed cardiac repolari...
Learn More
Gail Robertson, Eugenia Jones, Blake Anson | P05401US

Technology

Stable Cell Lines Expressing hERG1a and 1b

Cardiac IKr channels are targets associated with inherited and acquired long QT syndrome (LQTS), a disorder that can lead to ventricular arrhythmias. Previously, IKr channels were thought to be compos...
Learn More
Gail Robertson, Eugenia Jones, Jinling Wang | P03380US

Technology

Human Heart Sodium Channel Beta1 Subunit (SCNB1)

The human heart sodium channel beta1 subunit (SCNB1) is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel. In addition, SCNB1 is...
Learn More
Jonathan Makielski, Bin Ye | P03207US

Technology

HERG-1 Transfected HEK 293 Cell Line B

Re-polarization of the cardiac action potential, which plays a critical role in maintaining normal cardiac rhythm, occurs mainly due to the action of potassium ion (K+) currents in the heart. The most...
Learn More
Craig January, Zhengfeng Zhou, Qiuming Gong, Gail Robertson, Blake Anson, Matthew Trudeau, Corey Anderson | P04289US

Technology

Cell Line Stably Expressing KvLQT1 and minK

One of the key potassium channels in the heart is formed by the co-assembly of protein products from the KvLQT1 (KCNQ1) and minK (KCNE1) genes, which produce the slowly activating delayed rectifier po...
Learn More
Craig January, Sridharan Rajamani, Corey Anderson | P03073US

WARF