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47 Results for 'Cell lines'
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Technology
VACO6
A UW-Madison researcher has established a cell line, called VACO6, from a discarded tissue specimen of a surgically resected primary human colon cancer. The detailed characteristics of the clinical do...
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James Willson | P230180US01
Technology
PROBIOTIC STRAIN COLLECTION TO STUDY PROPHAGES
UW-Madison researchers have developed a number of variants of lytic strain L. reuteri ∆Φ1attB1∆Φ2∆attB2 (WARF case P170020). They are:
L. reuteri∆Φ1, in which prophage #1 is dele...
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Jan Peter Van Pijkeren, Jeehwan Oh | P230139US01
Technology
RHESUS MACAQUE INDUCED PLURIPOTENT STEM CELL (IPSC) LINE: LINE Rh2431
A UW-Madison researcher has developed a Rhesus Macaque induced pluripotent stem cell (iPSC) line, called the Rh2431 iPSC line.
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John Maufort | P230112US01
Technology
CYNOMOLGUS MACAQUE INDUCED PLURIPOTENT STEM CELL (IPSC) LINE: LINE cy0657
A UW-Madison researcher has developed a Cynomolgus Macaque induced pluripotent stem cell (iPSC) line, called the cy0657 iPSC line.
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John Maufort | P230113US01
Technology
METHOD FOR DIFFERENTIATION OF BRAIN MURAL CELLS FROM HUMAN PLURIPOTENT STEM CELLS
UW-Madison researchers disclose a new method for differentiating brain mural cells – encompassing pericytes and vascular smooth muscle cells – from hPSCs. The inventors used their previous...
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Eric Shusta, Benjamin Gastfriend, Sean Palecek | P220005US02
Technology
Immortalized Vocal Fold Fibroblasts
Normal vibration of vocal folds (aka vocal cords) depends on the tissue's composition and viscoelasticity. When that composition is altered by scarring or damage, the vibratory functionality of the vo...
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Susan Thibeault, Xia Chen | P190232US01
Technology
SufFeSient Cells
The commercially available E. coli strain BL21 λDE3 is commonly used for inducibly overexpressing recombinant proteins. Many derivatives of BL21 cells have been developed and commercialized, wi...
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Patricia Kiley, Erin Mettert | P190138US01
Technology
Vq Myeloma Cell Lines
UW Madison researchers' present invention is a set of two, new transgenic mouse multiple myeloma (MM) cell lines. Transgenic mice were developed expressing mutations in RAS pathway genes found in ...
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Jing Zhang | P210035US01
Technology
RPE CELL LINES WITH PLK4 CONDITIONAL KNOCKOUT AND ANALOG SENSITIVE MUTATION
UW-Madison researchers have developed two cell lines derived from RPE-1 cells (which were obtained from ATCC), an immortalized, non-transformed human epithelial cell line. “PLK4 WTflox/Delta&rdq...
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Mark Burkard, Ryan Denu | P210364US01
Technology
Human Basal Cell Carcinoma Cell Line UW-BCC1
Basal cell carcinoma (BCC) is the most common type of skin cancer, with around 3 million cases diagnosed each year. BCC involves the basal cells, which are in the deepest layer of the epidermis, the o...
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Vladimir Spiegelman, Felicite Noubissi Kamdem | P140339US01
Technology
CHO Cell Line Expressing HERG-1 Potassium Channels
HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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Gail Robertson, Barry Ganetzky, Jeffrey Warmke, Matthew Trudeau, Samuel Breit, Terence Campbell, Bruce Walker, Stella Valenzuela | P00082US
Technology
GATA2-Mutant Cells to Enable Cancer, Immunology, and Hematology Discoveries
GATA-binding-factor 2 (GATA2) is a transcription factor involved in stem cell maintenance and hematopoietic development. The gene encoding GATA2 often suffers germline and somatic mutations, which res...
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Emery Bresnick, Koichi Katsumura, Kirby Johnson | P200065US01
Technology
Induced Pluripotent Stem Cell Lines for Fragile X Syndrome Research
Fragile X syndrome (FXS) is a genetic disorder characterized by mild to moderate intellectual disability and a characteristic phenotype. It is the most common form of inherited intellectual disability...
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Anita Bhattacharyya Consigny, Su-Chun Zhang, Leonard Abbeduto | P160138US01
Technology
Induced Pluripotent Stem Cell Lines for Down Syndrome Research
Down syndrome (Trisomy 21, Ts21) is a condition caused by having an extra copy of the 21st chromosome due to an error in cell division. People born with Down syndrome have a characteristic phenotype a...
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Anita Bhattacharyya Consigny, Su-Chun Zhang | P160139US01
Technology
3T3-L1 Mouse PGC-1 Alpha Overexpression for Studying Mitochondrial Function and Aging
Mitochondrial function plays a central role in longevity and healthy aging, and delayed aging by calorie restriction activates PGC-1a (peroxisome proliferator-activated receptor gamma coactivator-1 al...
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Rozalyn Anderson, Samantha Wright, Stephen Martin, Porsha Howell, Josef Clark, Karl Miller | P200143US01
Technology
Induced Pluripotent Stem Cell Lines For Fragile X Research
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is closely linked with autism. The genetic basis of FXS is an expansion of CGG repeats in the 5'-untranslated ...
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Anita Bhattacharyya Consigny, Su-Chun Zhang, Leonard Abbeduto | P160138US02
Technology
Fluorescent-Tagged Moraxella Catarrhalis For Cell Culture Experiments
The present invention is a fluorescence-based cell assay for studying the replication of Moraxella catarrhalis. UW-Madison researchers developed a bacterial strain that fluoresces red by producing the...
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Cameron Currie, Reed Stubbendieck | P210244US01
Technology
Plasmids And Cell Lines Expressing The DMPK 3'UTR
The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs link...
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Mani Mahadevan, Jeffrey Amack | P210221US01
Technology
Systems And Methods For Determining Genotypes For Performing Physiological Functions
Systems and methods for determining genetic variations of an organism for performing a physiological function. The systems include a number of modules that can be integrated into existing metabolic en...
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Jennifer Reed, Christopher Tervo | P140140US03
Technology
Compositions And Methods Of Using Differentiated Cells Sensitized To Botulinum Neurotoxin
Differentiated cholinergic cells having motor neuron-like morphology and increased sensitivity to botulinum neurotoxin are provided herein. Methods of using such differentiated cells for detecting neu...
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Eric Johnson, Regina Whitemarsh, Sabine Pellett | P130013US02
Technology
Petri Dish With Single-Handed Lid Connection And Removal
A petri dish has interlock features between the lid and dish that allow single-handed engagement of the lid with the dish by rotation, so that the lid and dish may be raised by grasping only the lid w...
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Aleksandar Wood, Harpreet Singh | P190121US02
Technology
HLF-VC1 Master Cell Bank for Vaccine Development
FDA-qualified cell lines must be used for virus production for human vaccines. There are relatively few of these lines available and several (WI-38, MRC-5) used for virus production are becoming senes...
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James Gern | P160170US01
Technology
Multicolor Reporter Cells for Detecting and Quantifying HIV-1
It is estimated that half of new HIV infections in the U.S. are from patients who know they are HIV-positive but underestimate their transmissibility. Identifying and monitoring the latent HIV reservo...
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Nathan Sherer, Jordan Becker | P160337US02
Technology
Cell Lines for High Throughput Screening of Estrogenic Compounds
Two estrogen receptor isoforms regulate normal mammary cells in response to estrogen: ERα and ERβ. ERα is currently a therapeutic target in breast cancer, and breast cancers expressing ERα are com...
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Wei Xu, John Hawse, Frank Secreto | P150257US01
Technology
Bovine Macrophage Cell Line
Macrophages are white blood cells that ingest foreign material and play a crucial role in the immune system. Presently, there is no bovine macrophage cell line available for research and testing purpo...
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Charles Czuprynski, Dhammika Atapattu, Josely Figueiredo | P140060US01