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42 Results for 'Cell lines'
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Technology
Immortalized Vocal Fold Fibroblasts
Normal vibration of vocal folds (aka vocal cords) depends on the tissue's composition and viscoelasticity. When that composition is altered by scarring or damage, the vibratory functionality of the vo...
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Susan Thibeault, Xia Chen | P190232US01
Technology
SufFeSient Cells
The commercially available E. coli strain BL21 λDE3 is commonly used for inducibly overexpressing recombinant proteins. Many derivatives of BL21 cells have been developed and commercialized, wi...
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Patricia Kiley, Erin Mettert | P190138US01
Technology
Vq Myeloma Cell Lines
UW Madison researchers' present invention is a set of two, new transgenic mouse multiple myeloma (MM) cell lines. Transgenic mice were developed expressing mutations in RAS pathway genes found in ...
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Jing Zhang | P210035US01
Technology
RPE CELL LINES WITH PLK4 CONDITIONAL KNOCKOUT AND ANALOG SENSITIVE MUTATION
UW-Madison researchers have developed two cell lines derived from RPE-1 cells (which were obtained from ATCC), an immortalized, non-transformed human epithelial cell line. “PLK4 WTflox/Delta&rdq...
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Mark Burkard, Ryan Denu | P210364US01
Technology
Human Basal Cell Carcinoma Cell Line UW-BCC1
Basal cell carcinoma (BCC) is the most common type of skin cancer, with around 3 million cases diagnosed each year. BCC involves the basal cells, which are in the deepest layer of the epidermis, the o...
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Vladimir Spiegelman, Felicite Noubissi Kamdem | P140339US01
Technology
CHO Cell Line Expressing HERG-1 Potassium Channels
HERG-1 (human ether-a-go-go-related gene) potassium channels mediate repolarization of cardiac action potentials. Loss of function mutations in hERG-1 can result in long QT syndrome, an inherited diso...
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Gail Robertson, Barry Ganetzky, Jeffrey Warmke, Matthew Trudeau, Samuel Breit, Terence Campbell, Bruce Walker, Stella Valenzuela | P00082US
Technology
GATA2-Mutant Cells to Enable Cancer, Immunology, and Hematology Discoveries
GATA-binding-factor 2 (GATA2) is a transcription factor involved in stem cell maintenance and hematopoietic development. The gene encoding GATA2 often suffers germline and somatic mutations, which res...
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Emery Bresnick, Koichi Katsumura, Kirby Johnson | P200065US01
Technology
Induced Pluripotent Stem Cell Lines for Fragile X Syndrome Research
Fragile X syndrome (FXS) is a genetic disorder characterized by mild to moderate intellectual disability and a characteristic phenotype. It is the most common form of inherited intellectual disability...
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Anita Bhattacharyya Consigny, Su-Chun Zhang, Leonard Abbeduto | P160138US01
Technology
Induced Pluripotent Stem Cell Lines for Down Syndrome Research
Down syndrome (Trisomy 21, Ts21) is a condition caused by having an extra copy of the 21st chromosome due to an error in cell division. People born with Down syndrome have a characteristic phenotype a...
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Anita Bhattacharyya Consigny, Su-Chun Zhang | P160139US01
Technology
3T3-L1 Mouse PGC-1 Alpha Overexpression for Studying Mitochondrial Function and Aging
Mitochondrial function plays a central role in longevity and healthy aging, and delayed aging by calorie restriction activates PGC-1a (peroxisome proliferator-activated receptor gamma coactivator-1 al...
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Rozalyn Anderson, Samantha Wright, Stephen Martin, Porsha Howell, Josef Clark, Karl Miller | P200143US01
Technology
Induced Pluripotent Stem Cell Lines For Fragile X Research
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is closely linked with autism. The genetic basis of FXS is an expansion of CGG repeats in the 5'-untranslated ...
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Anita Bhattacharyya Consigny, Su-Chun Zhang, Leonard Abbeduto | P160138US02
Technology
Plasmids And Cell Lines Expressing The DMPK 3'UTR
The UW Madison researchers' invention is a set of plasmid constructs and cell lines developed to investigate the effects of RNA toxicity in myotonic dystrophy. The inventor created two constructs link...
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Mani Mahadevan, Jeffrey Amack | P210221US01
Technology
Fluorescent-Tagged Moraxella Catarrhalis For Cell Culture Experiments
The present invention is a fluorescence-based cell assay for studying the replication of Moraxella catarrhalis. UW-Madison researchers developed a bacterial strain that fluoresces red by producing the...
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Cameron Currie, Reed Stubbendieck | P210244US01
Technology
Systems And Methods For Determining Genotypes For Performing Physiological Functions
Systems and methods for determining genetic variations of an organism for performing a physiological function. The systems include a number of modules that can be integrated into existing metabolic en...
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Jennifer Reed, Christopher Tervo | P140140US03
Technology
Petri Dish With Single-Handed Lid Connection And Removal
A petri dish has interlock features between the lid and dish that allow single-handed engagement of the lid with the dish by rotation, so that the lid and dish may be raised by grasping only the lid w...
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Aleksandar Wood, Harpreet Singh | P190121US02
Technology
Compositions And Methods Of Using Differentiated Cells Sensitized To Botulinum Neurotoxin
Differentiated cholinergic cells having motor neuron-like morphology and increased sensitivity to botulinum neurotoxin are provided herein. Methods of using such differentiated cells for detecting neu...
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Eric Johnson, Regina Whitemarsh, Sabine Pellett | P130013US02
Technology
HLF-VC1 Master Cell Bank for Vaccine Development
FDA-qualified cell lines must be used for virus production for human vaccines. There are relatively few of these lines available and several (WI-38, MRC-5) used for virus production are becoming senes...
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James Gern | P160170US01
Technology
Multicolor Reporter Cells for Detecting and Quantifying HIV-1
It is estimated that half of new HIV infections in the U.S. are from patients who know they are HIV-positive but underestimate their transmissibility. Identifying and monitoring the latent HIV reservo...
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Nathan Sherer, Jordan Becker | P160337US02
Technology
Cell Lines for High Throughput Screening of Estrogenic Compounds
Two estrogen receptor isoforms regulate normal mammary cells in response to estrogen: ERα and ERβ. ERα is currently a therapeutic target in breast cancer, and breast cancers expressing ERα are com...
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Wei Xu, John Hawse, Frank Secreto | P150257US01
Technology
Bovine Macrophage Cell Line
Macrophages are white blood cells that ingest foreign material and play a crucial role in the immune system. Presently, there is no bovine macrophage cell line available for research and testing purpo...
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Charles Czuprynski, Dhammika Atapattu, Josely Figueiredo | P140060US01
Technology
Adapted Rhinovirus C for Maximum Virus Yield
Human rhinoviruses (species A, B and C) encompass more than 160 types that are responsible for the majority of upper respiratory tract infections (common colds) and many of the lower respiratory tract...
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James Gern, Yury Bochkov, Ann Palmenberg, Kelly Watters | P160050US02
Technology
New Viral Propagation Method Yields Insight Into Childhood Asthma
In addition to the common cold, human rhinoviruses (RV) trigger nearly half of all cases of asthma exacerbation. Wheezing illnesses in infancy caused by RV are associated with a high risk of developin...
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James Gern, Yury Bochkov, Ann Palmenberg | P140382US02
Technology
Reprogrammed Stem Cell Line for Research: IISH4i-CBT4
Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying hematopoietic development in vitro.
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Igor Slukvin, Kejin Hu, James Thomson | P120130US02
Technology
Reprogrammed Stem Cell Line for Research: IISH3i-CB6
Reprogramming blood cells to induced pluripotent stem cells (iPSCs) provides a novel tool for studying blood development in vitro.
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Igor Slukvin, Kejin Hu, James Thomson | P120130US01
Technology
Cryopreserved Head and Neck Cancer Tumorgrafts and Related Cell Strains
Tumor xenograft mouse models have been created by injecting human cancer cell lines into immune deficient mice. However, when the effects of various interventions on these models are assessed, the res...
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Paul Lambert, Paul Harari, Randall Kimple, Robert Yang, Alexandra Torres | P120167US01