Described herein is cancer biomarker, e.g., a vesicle, capture surface that includes a substrate, a first plurality of nanoparticles attached to the substrate; a plurality of bifunctional tethers, whe...
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The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
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Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.
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It is estimated that half of new HIV infections in the U.S. are from patients who know they are HIV-positive but underestimate their transmissibility. Identifying and monitoring the latent HIV reservo...
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Colorectal cancer is a major cause of cancer-related morbidity and mortality in developed nations, causing more than 600,000 deaths worldwide every year. While early detection of localized colorectal ...
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Advances in screening and detection have led to an increase in the diagnosis of early stage breast cancer. Plotting the optimal course of treatment (i.e., more or less aggressive) remains a challenge,...
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Gram-negative bacterial infections are an ongoing challenge to health care providers worldwide. Detection, treatment and control of such pathogens have gained increasing importance in the context of a...
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Mycobacterial infections cause major health problems for people and animals, including human tuberculosis, bovine tuberculosis and Johne’s disease. Johne’s disease (or paratuberculosis) afflicts 9...
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Fungal infections such as aspergillosis and Valley Fever can be life threatening, particularly in immune-compromised patients. These patients are vulnerable to fungal strains that flourish in hospital...
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Prostate cancer is the second most common cancer in American men, causing more than 27,000 deaths every year. An estimated one man in seven will be diagnosed with prostate cancer during his lifetime. ...
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Ovarian cancer is the most fatal gynecological cancer, killing 15,000 women in the Unites States every year. The overall five-year relative survival rate for women with ovarian cancer is 46 percent. T...
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Blastomyces dermatitidis is a soil fungus found throughout the world, and is especially prevalent in the river valleys and Great Lakes region of the United States. If spores are inhaled, blastomycosis...
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Mengovirus is a picornavirus that causes encephalomyocarditis in humans and other animals.
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Almost 200,000 men in the United States develop prostate cancer each year. More than 60,000 people develop melanoma. Early diagnosis is key to survival because the best treatment and prognosis for the...
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Botulinum neurotoxins produced by Clostridium botulinum are the most potent toxins known. Because of the threat of bio-terrorism, sensitive methods for detecting botulinum neurotoxin are needed; howev...
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DNA damage occurs in organisms as a result of exposure to environmental chemicals and radiation. Failure to repair this damage can lead to tumor formation and cancer. Although a gene has been found in...
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The NADH cytochrome b5 reductase/cytochrome b5 system can transfer electrons to other enzymes, including those involved in the metabolism of fatty acids, toxins and drugs. In the past, NADH cytochrome...
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La Crosse virus is an etiologic agent for childhood encephalitis in North America. Structurally, the nucleocapsid of this virus is enclosed by a host-derived lipid envelope holding two virion glycopro...
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Each year, approximately 20,000 American women are diagnosed with ovarian cancer and about 15,000 women die of the disease.  The overall five-year relative survival rate for women with ovarian ca...
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Botulinum toxin is used for cosmetic procedures and to treat neurological disorders from spasmodic disorders to chronic pain syndromes.  The most widely used form of botulinum toxin is the seroty...
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Influenza is a major human disease caused by one of three types of influenza viruses. Type A viruses cause the most severe illnesses and are responsible for most epidemics; type B viruses generally ca...
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