A new cancer treatment being studied at a few major centers including UW Health is CAR T (Chimeric Antigen Receptor T cell) therapy. CAR T therapy uses a patient's own cells and 'reengineers' them to ...
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The importance of T cells in immunotherapy is driving the development of technologies to better characterize T cells and improve therapeutic efficacy. One specific objective is assessing antigen-induc...
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The separation or isolation of proteins from a heterogeneous mixture is a common practice in scientific experimentation and the manufacturing of biologic reagents. Commercially available kits and cur...
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Bacterial contamination is a major risk in biologics manufacturing and the presence of endotoxin, an outer membrane component of Gram-negative bacteria, is vigorously tested for in protein and DNA/RNA...
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Selection intensity for higher milk production in dairy cattle has contributed to a decline in fertility, posing a challenge to dairy producers. Despite technological advances, the pregnancy rate of c...
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The term glucoregulatory dysfunction covers a spectrum of disorders from insulin resistance to prediabetes and diabetes. Problems associated with glucoregulatory dysfunction and obesity dominate healt...
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Cancer treatment planning remains an ongoing challenge to oncologists and patients alike, with each cancer being genetically unique and requiring personalized approaches. Greater outcome success will ...
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UW-Madison researchers previously described a method of determining whether or not an animal is suffering from a catabolic change by sampling isotope changes in breath or blood.
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The catabolic state refers to the condition where the body uses stores of carbohydrates, amino acids or fats as a source of energy for maintenance. The catabolic state may be induced by infection, dis...
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An otoscope is a classic, handheld medical device that allows a doctor to look into the ear canal and tympanic membrane (eardrum). This is important for diagnosing ear infections, membrane ruptures an...
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Prostate cancer is the second most common cancer in American men, causing more than 27,000 deaths every year. An estimated one man in seven will be diagnosed with prostate cancer during his lifetime. ...
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Approximately 15 million Americans suffer from a swallowing disorder (dysphagia). People with acid reflux, a neurological disorder or cancer of the head and neck are particularly at risk. The leading ...
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Compact solid-state LED/LD (light-emitting diode) light sources are by their nature near-point sources. Applications that take advantage of these highly efficient, spectrally engineered light sources ...
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Newborn screening is the practice of testing newborns for certain harmful or potentially fatal disorders that are not otherwise apparent at birth. Generally, blood drops are obtained from the heel, fi...
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Time-frequency analysis involves detecting when oscillations of certain frequencies turn on and off. This kind of analysis is useful in nearly every field of science and engineering. The traditional a...
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Fiber optic probes can be used for spectroscopic measurement of tissue. A fiber optic tube emits light on one side of the tissue that is absorbed and measured on the other side by fiber optic detector...
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CREB is a transcription factor that has been implicated as a critical regulator of neuronal function and survival. Knockout mice lacking CREB exhibit a disease similar to ataxia telangiectasia, a neur...
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Light-based diagnostics are used to create images of human tissue to detect the development of diseases like cancer. The popularity of light-based diagnostics is growing due to their non-intrusive nat...
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Epileptogenesis, or the occurrence of spontaneous seizures, is considered to be a learned response due to brain plasticity.  The development of the condition requires circuits in the brain to pos...
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The inflammatory response plays a role in illnesses from injury to infections to allergies.  Initiation of inflammation involves the activation of immune cells that trigger a cascade of events le...
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Diffuse reflectance spectroscopy can be used to measure tissue absorption and scattering, which reflect the intrinsic physiological and structural properties of tissue respectively. This technique can...
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The early detection of disease or malignancy can greatly increase the probability of full recovery, especially in the case of cancers.  Optical diagnostic techniques, such as diffuse reflectance ...
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Phsyicians often use microscopic visual inspection followed by biopsy to detect cancer; however, this method is limited in many ways. Optical techniques are a promising alternative that allows clinici...
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A complex network of biochemical processes underlies living systems. As these biochemical processes change, there is a corresponding change in the biological substances that are consumed or produced. ...
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Skin cancer detection is typically identified via standard visual inspection. Skin patches with asymmetrical outlines, irregular borders, mottled color or a diameter greater than six millimeters are a...
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