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34 Results for 'Drug production & design'
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Technology
Safer Influenza Vaccine from Replication-Knock Out Virus
Influenza viruses instigate annual global epidemics. The first influenza pandemic in 40 years occurred during the 2009-2010 season, when a novel H1N1 strain emerged and spread worldwide. The United St...
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Yoshihiro Kawaoka, Gabriele Neumann, Makoto Ozawa | P110003US02
Technology
Improved Asymmetric Hydroformylation of Therapeutics Using Novel Bisphosphines
Asymmetric synthesis is important in the pharmaceutical industry because frequently only one optically active isomer, or enantiomer, is therapeutically active. Therefore, it is often desirable to sele...
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Clark Landis, Thomas Clark, Jerzy Klosin | P04447US
Technology
Method for Assessing 3-D Crystal Structures from in Situ Digital Images
Suspension crystallization processes often result in crystals with a wide range of particle sizes. Accurately controlling the distribution of shapes and sizes is a challenge in the pharmaceutica...
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James Rawlings, Nicola Ferrier, Paul Larsen | P06449US
Technology
Microfluidics Platform and Method That Mimic the Cellular Environment
Most biochemical interactions are studied in solutions containing dilute concentrations of molecules. However, the complexity of the cellular environment makes it difficult to compare the results of s...
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David Beebe, Jaisree Moorthy, Richard Burgess | P04153US
Technology
Biosynthetic Gene Cluster That Produces the Natural Antibiotics Platensimycin and Platencin
As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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Ben Shen, Michael Smanski | P07515US
Technology
Recombinant Influenza Viruses for Vaccines and Gene Therapy
Influenza viruses show strong potential as vaccine and gene delivery vectors: they do not replicate through DNA intermediates (which may incorporate into the host genome); they elicit strong immune re...
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Yoshihiro Kawaoka, Gabriele Neumann | P99264US
Technology
High Titer Recombinant Influenza Viruses for Vaccines and Gene Therapy
Influenza is a major disease in humans that can be prevented by vaccination. Because new epidemic strains arise every year or two, the conventional influenza vaccine must be adapted almost every year,...
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Yoshihiro Kawaoka | P03322US
Technology
VeA, a Global Regulator of Secondary Metabolism, Can Increase Production of Secondary Metabolites
Microorganisms, such as fungi, produce a variety of secondary metabolites. These secondary metabolites display a broad range of activities, including antibiotic, immunosuppressant, phytotoxic an...
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Nancy Keller, Saori Campen | P09056US02
Technology
Type 1 Polyketide Synthase Extender Units
Microorganisms produce a variety of biologically active secondary metabolites, which display a range of useful antibiotic and immunosuppressant activities. One class of secondary metabolites, known as...
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Michael Thomas, Jo Handelsman, Yolande Chan, Angela Podevels | P06464US