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38 Results for 'Genomics & proteomics'
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Technology
An Optimized, More Efficient Method for Characterizing Microorganisms and Viruses Using Metagenomics
Metagenomics is the study of genetic material from environmental samples for detecting microbes, especially pathogens. It is increasingly used within clinical and industrial settings. While metagenomi...
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Tony Goldberg, Samuel Sibley | P160266US02
Technology
MULTIPLEXED DILEU-BIOTIN-AZIDE (DBA) TAG ENABLED ISOBARIC TANDEM ORTHOGONAL PROTEOLYSIS ACTIVITY-BASED PROTEIN PROFILING (ISOBOP-ABPP) PLATFORM FOR HIGH-THROUGHPUT QUANTITATIVE PAN-PTM ANALYSIS
UW-Madison researchers have developed a set of novel isobaric chemical tags, DiLeu-Biotin-Azide (DBA), that could be useful in proteomics, particularly quantification of post translational modificatio...
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Lingjun Li, Miyang Li, Min Ma | P220286US02
Technology
UNIVERSAL METHOD FOR PARASITE AND EUKARYOTIC ENDOSYMBIONT IDENTIFICATION
UW-Madison researchers have developed and validated a novel “parasitome” method to accurately characterize parasites in samples. Like published metabarcoding protocols, the new method consists of ...
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Tony Goldberg, Leah Owens | P220194WO01
Technology
PHOTO-CLEAVABLE SURFACTANTS
UW-Madison researchers have developed photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded ...
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Ying Ge, Song Jin, Tania Guardado Alvarez, Kyle Brown | P180335US03
Technology
Methods Of Genome Editing Including Controlled Opening Of Chromatin
UW-Madison researchers developed an improved method of gene editing human iPSCs through CRISPR-Cas. They added the histone deacetylase small molecule inhibitor Trichostatin A (TSA) before addition of ...
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Krishanu Saha, Kaivalya Molugu | P220049US02
Technology
A Novel Counter-Selection Marker for Use in Lactic Acid Bacteria
Lactic acid bacteria constitute a large group of Gram-positive bacteria (over 200 species described), of which Lactobacillus is the largest genus in the lactic acid bacteria group. Members of the Lact...
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Jan Peter Van Pijkeren, Jeehwan Oh | P160379US01
Technology
Kras Conditional Knockout Allele
Differentiation of normal stem cells into the correct cell lineage is a tightly controlled process that involves cell-cell and cell-extracellular matrix interactions as well as signaling through cellu...
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Jing Zhang | P210181US01
Technology
System, Process And Software Arrangement For Disease Detection Using Genome Wide Haplotype Maps
System, process and software arrangement produces high resolution, high accuracy, ordered, genome wide haplotyped maps from single molecule based approximate ordered maps and the location of genes res...
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Tom Anantharaman, Bud Mishra, Will Casey | P05170US04
Technology
Planar High-Speed Molecule Sequencer
A molecule sequencer uses a planar nanochannel for aligning molecules to flow past impedance interrogation electrodes mounted across the channel for rapid sequencing. The electrodes may be fixed to th...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P180156US01
Technology
Systems And Methods For Fully Automated Protein Engineering
Systems and methods for protein engineering. The systems include a sequence testing subsystem and a machine learning subsystem. The sequence testing subsystem is configured to express proteins and tes...
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Philip Romero, Bennett Bremer, Jacob Rapp | P190269US02
Technology
Accurate Determination of Metabolite Concentrations in Cell Extracts or Biological Fluids
Metabolomics, or the systematic study of all metabolites in an organism, is one of the fastest growing areas of scientific research. Nuclear magnetic resonance (NMR) spectroscopy is one tool used to a...
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John Markley, Ian Lewis, William Westler, Qiu Cui, Gabriel Cornilescu, Marco Tonelli | P07362US
Technology
Nanopore Antennas for Ultrahigh Speed DNA Sequencing
‘Nanopore sequencing’ allows a single molecule such as DNA to be analyzed without conventional tools like chemical labels or costly optical instruments. In the process, DNA strands and a stream of...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P140109US01
Technology
Computer-Based Determination of Haplotype
Humans are diploid organisms whose (non-sex) cells contain two copies of each chromosome – one from each parent. Each of these two copies may be distinguished by genetic variations such as insertion...
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Tom Anantharaman, Bud Mishra, Will Casey | P05170US
Technology
Use of Nanomaterials to Enrich Phosphopeptides for Mass Spectrometry-Based Proteomics
Proteomics is a relatively new discipline that is a large scale study of proteins. It includes systematically identifying the sequence, characterizing the structure and evaluating the function of all ...
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Song Jin, Ying Ge, Cory Nelson, Qingge Xu | P08123US02
Technology
Real-Time Tandem Mass Spectral Data Analysis for Protein Sequence Identification
Protein characterization has become an integral part of modern biology, even inspiring a new discipline known as proteomics, or the classification of proteins based on the genome of an organism. MS ...
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Joshua Coon, Gheorghe Craciun, Shane Hubler | P08040US
Technology
Identifying Related Peak Sets to Boost Mass Spectrometry Throughput
Tandem mass spectrometry (MS/MS) is a technique capable of identifying large numbers of proteins in complex biological samples. In the process, peptides are ionized and an initial survey scan (i.e., a...
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Joshua Coon, Michael Westphall, Derek Bailey | P120336US01
Technology
DNA Sequencing with Piezoelectric Nanopore
‘Nanopore sequencing’ holds the potential for sequencing a single molecule of DNA without the need for conventional tools like chemical labels or costly optical instruments. This promising method ...
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Robert Blick, Eric Stava | P130036US01
Technology
Cost-Effective Isobaric Tandem Mass Tags for High Throughput Quantitative Proteomics and Peptidomics
Mass spectrometry (MS) is a vital tool for identifying and tallying the different proteins, peptides and other molecules in a sample. To determine relative abundance, reagent tags are used to label th...
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Lingjun Li, Feng Xiang, Tyler Greer, Dustin Frost, Zhidan Liang | P110257US02
Technology
GFAbs – GFP-Based Biosensors with the Binding Properties of Antibodies
Antibodies are used widely in biological and medical research to bind to and help isolate molecules of interest. However, the reduced stability and production yields of antibody fragments frequently...
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Eric Shusta, Tej Pavoor | P09101US03
Technology
Increasing Peptide and Protein Identifications with Prioritized Mass Spectrometry
As resources shift from genome sequencing to understanding and characterizing expressed genes and protein function, reliable and rapid tools for the analysis of protein composition are increasingly vi...
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Joshua Coon, Douglas Phanstiel, Graeme McAlister | P110191US01
Technology
Mass Spectrometry Data Acquisition Method Enables More Reliable Large-Scale Protein Quantitation
Quantitative analysis in chemistry is the determination of the absolute or relative abundance of substances present in a sample. For biological samples, quantitative analysis performed via mass spectr...
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Joshua Coon, Craig Wenger, Douglas Phanstiel | P100173US02
Technology
Efficient Whole Genome Analysis System
In addition to simple nucleotide polymorphisms, the human genome includes intermediate structural variations, such as amplifications, insertions, deletions, inversions and complex rearrangements. Whil...
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David Schwartz, Konstantinos Potamousis, Shiguo Zhou, Steven Goldstein, Michael Newton, Rodney Runnheim, Daniel Forrest, Christopher Churas | P07298US
Technology
Markerless Gene Replacement Plasmids for E. coli
Microbial genome sequencing projects uncover large numbers of new genes. Functional analyses of these genes require targeted modifications of particular DNA sequences in their chromosomal locations us...
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Frederick Blattner, Gyorgy Posfai, Vitaliy Kolisnychenko, Zsuzsa Bereczki | P01153US
Technology
Electrospray Ionization Ion Source with Tunable Charge Reduction
Analysis by mass spectrometry requires that molecules first be converted to gas-phase ions. Converting small molecules into ions is straightforward; however, it was not possible to ionize large molecu...
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Lloyd Smith, Brian Frey, Michael Westphall | P05387US
Technology
Bacterial Culture Collection from an Extreme Environment in Alaska
Microorganisms adapted to grow in exceptionally harsh environments, such as hot springs and arctic soils, are a potentially vast source of novel metabolic processes, antibiotics, enzymes and other pro...
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Jo Handelsman, Patrick Schloss | P03154US