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36 Results for 'Genomics & proteomics'
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Technology
Methods And Systems For Isolating And Identifying Nucleic Acid From A Plurality Of Microorganisms And Viruses
Tony Goldberg, Samuel Sibley | P160266US02
Technology
Systems And Methods For Fully Automated Protein Engineering
Philip Romero, Bennett Bremer, Jacob Rapp | P190269US02
Technology
Accurate Determination of Metabolite Concentrations in Cell Extracts or Biological Fluids
Metabolomics, or the systematic study of all metabolites in an organism, is one of the fastest growing areas of scientific research. Nuclear magnetic resonance (NMR) spectroscopy is one tool used to a...
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John Markley, Ian Lewis, William Westler, Qiu Cui, Gabriel Cornilescu, Marco Tonelli | P07362US
Technology
Nanopore Antennas for Ultrahigh Speed DNA Sequencing
‘Nanopore sequencing’ allows a single molecule such as DNA to be analyzed without conventional tools like chemical labels or costly optical instruments. In the process, DNA strands and a stream of...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P140109US01
Technology
Computer-Based Determination of Haplotype
Humans are diploid organisms whose (non-sex) cells contain two copies of each chromosome – one from each parent. Each of these two copies may be distinguished by genetic variations such as insertion...
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Tom Anantharaman, Bud Mishra, Will Casey | P05170US
Technology
Real-Time Tandem Mass Spectral Data Analysis for Protein Sequence Identification
Protein characterization has become an integral part of modern biology, even inspiring a new discipline known as proteomics, or the classification of proteins based on the genome of an organism. ...
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Joshua Coon, Gheorghe Craciun, Shane Hubler | P08040US
Technology
Use of Nanomaterials to Enrich Phosphopeptides for Mass Spectrometry-Based Proteomics
Proteomics is a relatively new discipline that is a large scale study of proteins. It includes systematically identifying the sequence, characterizing the structure and evaluating the function of all ...
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Song Jin, Ying Ge, Cory Nelson, Qingge Xu | P08123US02
Technology
Identifying Related Peak Sets to Boost Mass Spectrometry Throughput
Tandem mass spectrometry (MS/MS) is a technique capable of identifying large numbers of proteins in complex biological samples. In the process, peptides are ionized and an initial survey scan (i.e., a...
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Joshua Coon, Michael Westphall, Derek Bailey | P120336US01
Technology
DNA Sequencing with Piezoelectric Nanopore
‘Nanopore sequencing’ holds the potential for sequencing a single molecule of DNA without the need for conventional tools like chemical labels or costly optical instruments. This promising...
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Robert Blick, Eric Stava | P130036US01
Technology
Cost-Effective Isobaric Tandem Mass Tags for High Throughput Quantitative Proteomics and Peptidomics
Mass spectrometry (MS) is a vital tool for identifying and tallying the different proteins, peptides and other molecules in a sample. To determine relative abundance, reagent tags are used to label th...
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Lingjun Li, Feng Xiang, Tyler Greer, Dustin Frost, Zhidan Liang | P110257US02
Technology
GFAbs – GFP-Based Biosensors with the Binding Properties of Antibodies
Antibodies are used widely in biological and medical research to bind to and help isolate molecules of interest. However, the reduced stability and production yields of antibody fragments freque...
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Eric Shusta, Tej Pavoor | P09101US03
Technology
Increasing Peptide and Protein Identifications with Prioritized Mass Spectrometry
As resources shift from genome sequencing to understanding and characterizing expressed genes and protein function, reliable and rapid tools for the analysis of protein composition are increasingly vi...
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Joshua Coon, Douglas Phanstiel, Graeme McAlister | P110191US01
Technology
Mass Spectrometry Data Acquisition Method Enables More Reliable Large-Scale Protein Quantitation
Quantitative analysis in chemistry is the determination of the absolute or relative abundance of substances present in a sample. For biological samples, quantitative analysis performed via mass spectr...
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Joshua Coon, Craig Wenger, Douglas Phanstiel | P100173US02
Technology
Double-Strand DNA Break Repair in Vitro – Forensic and Genomic Applications
Since the 1980s, DNA typing of biological evidence has played a central role in forensic science. This technology has helped solve crimes nationwide, and also has helped exonerate wrongly accuse...
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Michael Cox, John Battista, Audrey Klingele, Joseph Piechura | P090366US02
Technology
Efficient Whole Genome Analysis System
In addition to simple nucleotide polymorphisms, the human genome includes intermediate structural variations, such as amplifications, insertions, deletions, inversions and complex rearrangements. Whil...
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David Schwartz, Konstantinos Potamousis, Shiguo Zhou, Steven Goldstein, Michael Newton, Rodney Runnheim, Daniel Forrest, Christopher Churas | P07298US
Technology
Markerless Gene Replacement Plasmids for E. coli
Microbial genome sequencing projects uncover large numbers of new genes. Functional analyses of these genes require targeted modifications of particular DNA sequences in their chromosomal locations us...
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Frederick Blattner, Gyorgy Posfai, Vitaliy Kolisnychenko, Zsuzsa Bereczki | P01153US
Technology
Input Feature and Kernel Selection Improves Speed, Accuracy and Efficiency of Support Vector Machine Classification
Support vector machines (SVMs) are powerful tools for classifying data that are often used in data mining operations. An SVM classifies data in extremely large data sets by identifying a linear or non...
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Olvi Mangasarian, Glenn Fung | P03201US
Technology
Electrospray Ionization Ion Source with Tunable Charge Reduction
Analysis by mass spectrometry requires that molecules first be converted to gas-phase ions. Converting small molecules into ions is straightforward; however, it was not possible to ionize large molecu...
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Lloyd Smith, Brian Frey, Michael Westphall | P05387US
Technology
Bacterial Culture Collection from an Extreme Environment in Alaska
Microorganisms adapted to grow in exceptionally harsh environments, such as hot springs and arctic soils, are a potentially vast source of novel metabolic processes, antibiotics, enzymes and other pro...
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Jo Handelsman, Patrick Schloss | P03154US
Technology
Unique, Full-Length Mouse cDNAs
The study of full-length cDNA clones is important for determining the structure and function of genes.
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Christopher Bradfield | P03413US
Technology
Libraries of Bacterial Genomic DNA Isolated from Alaskan Soils
Cultured microorganisms produce an extraordinary array of structurally diverse and valuable organic compounds; however, microbes that can be brought into culture by standard techniques represent only ...
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Jo Handelsman, Lynn Williamson | P04104US
Technology
10,000 Sequenced Mouse Genomic Clones Derived From a CpG Library
CpG islands are areas of DNA containing a high CpG content, which often correspond to promoter regions.
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Peggy Farnham | P04394US
Technology
Bacterial Genomic Libraries from Alaskan Soils (AK 9-13 and 16)
Cultured microorganisms produce an extraordinary array of structurally diverse and valuable organic compounds; however, microbes that can be cultured using standard techniques represent only a small f...
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Jo Handelsman, Lynn Williamson, Heather Allen | P05158US
Technology
Super Bac 1 - An Inducible Vector With Shuttle Capability
Because they retain large DNA inserts over many generations, bacterial artificial chromosomes (BACs) are popular vectors for genetic and expression analyses of genomic DNA libraries; however, their us...
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Jo Handelsman, Robert Goodman, David Mann | P01167US
Technology
Janthinobacterium lividium Isolates from Alaskan Soil
Microorganisms adapted to grow in exceptionally harsh environments, such as hot springs and arctic soils, are a potentially vast source of novel metabolic processes, antibiotics, enzymes and other pro...
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Jo Handelsman, Patrick Schloss, Amy Klimowicz | P06058US