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31 Results for 'Mass spectrometry'
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Technology
UW-Madison researchers have developed a novel mass spectrometry (MS)-based method for simultaneous qualitative and quantitative protein citrullination analysis from biological and clinical samples. Th...
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Lingjun Li, Yatao Shi, Zihui Li | P190302US02
Technology
RETRACTABLE ION GUIDE, GRID HOLDER, AND TECHNOLOGY FOR REMOVAL OF CRYOGENIC SAMPLE FROM VACUUM
UW-Madison researchers have developed an improved sample handling system for the preparation of samples to be analyzed using cryo-electron microscopy (cryo-EM). The system includes a retractable grid ...
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Joshua Coon, Michael Westphall | P200355US02
Technology
FREEZING AND JACKETING GAS-PHASE BIOMOLECULES WITH AMORPHOUS ICE FOR ELECTRON MICROSCOPY
UW-Madison researchers have developed an improved technique for cryogenically fixing biological samples in amorphous ice for analysis by cryo-electron microscopy (cryo-EM). Analyte particles are...
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Joshua Coon, Michael Westphall | P200354WO01
Technology
High Mass Accuracy Filtering For Improved Spectral Matching Of High-Resolution Gas Chromatography-Mass Spectrometry Data Against Unit-Resolution Reference Databases
The invention provides methods, systems and algorithms for identifying high-resolution mass spectra. In some embodiments, an analyte is ionized and analyzed using high-resolution mass spectrometry (MS...
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Joshua Coon, Nicholas Kwiecien, Derek Bailey, Michael Westphall | P140184US02
Technology
Method To Perform Beam-Type Collision-Activated Dissociation In The Pre-Existing Ion Injection Pathway Of A Mass Spectrometer
Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dis...
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Joshua Coon, Graeme McAlister | P09349US02
Technology
Membrane Detector For Time-Of-Flight Mass Spectrometry
The invention provides methods, and related devices and device components, for detecting, sensing and analyzing analytes in samples. In some aspects, the invention provides methods, and related device...
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Robert Blick, Jonghoo Park | P110072US02
Technology
Mass Defect-Based Multiplex Dimethyl Pyrimidinyl Ornithine (Dipyro) Tags For High-Throughput Quantitative Proteomics And Peptidomics
The use of mass defect signatures to impart milliDalton mass differences between isotopically labeled peptides at the MS1-level allows multiplex quantification without the increased mass spectral comp...
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Lingjun Li, Dustin Frost, Amanda Buchberger Jones | P150350US02
Technology
Methods And Systems For Transmission And Detection Of Free Radicals
The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from...
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J. Leon Shohet, Michael Sussman, Faraz Choudhury, Benjamin Minkoff, Grzegorz Sabat, Joshua Blatz | P170004US02
Technology
Gas Phase Sample Preparation For Cryo-Electron Microscopy
The present invention provides methods for controllably forming a layer of amorphous ice and other amorphous solids on a substrate, and also provides cryoelectron microscopy (cryo-EM) sample preparati...
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Joshua Coon, Michael Westphall | P170235US02
Technology
Isobaric Multiplex Reagents For Carbonyl Containing Compound High-Throughput Quantitative Analysis
The present invention provides a set of novel isobaric chemical tags, also referred herein as SUGAR (Isobaric Multiplex Reagents for Carbonyl Containing Compound). These labeling tags are compact and ...
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Lingjun Li, Yu Feng, Bingming Chen, Qinying Yu, Xuefei Zhong, Miyang Li | P180060US02
Technology
Improved Molecule Mass Detection Using Electron Field Emission from Kinetically Impacted Membranes
Mass spectrometry is a broadly applicable analysis tool for detecting and characterizing molecules and other chemical species, including complex mixtures of biomolecules such as peptides, proteins or ...
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Robert Blick, Lloyd Smith, Michael Westphall, Hua Qin | P09192US
Technology
Research Tool for Protein Conformation Analysis
The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Michael Sussman, J. Leon Shohet, Faraz Choudhury, Joshua Blatz, Benjamin Minkoff, Daniel Benjamin | P160180US02
Technology
Improved Sensor Enables Sensitive Detection of Large Molecules in Mass Spectrometry
Mass spectrometry is a highly selective and quantitative technique that is widely used to determine the chemical composition of a sample. Applications of this analytical tool include measuring isotope...
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Robert Blick, Michael Westphall, Lloyd Smith | P05110US
Technology
New Mass Spectrometry Detector Uses Optically Active Membrane
Mass spectrometers are analytical instruments that can precisely measure the mass of molecules to determine their composition and identity. Generally, the molecules are ionized and then accelerated by...
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Robert Blick, Jonathan Rodriguez, Hyunseok Kim, Zlatan Aksamija, Wolfgang Hansen, Christian Heyn | P140174US01
Technology
Multiplexed Mass Spectrometry Quantification with Neutron-Encoded Mass Tags
In the past decade, cataloguing the thousands of proteins present in a cell using mass spectrometry (MS) has matured into a procedure both deeply vital and straightforward. Yet discovering how such mo...
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Joshua Coon, Alexander Hebert | P130032US01
Technology
Faster Gas-Phase Protein Sequencing
Determining the amino acid sequence of any given protein or polypeptide is a formidable task. The first major technology to emerge for this purpose was the Edman degradation method, which sequences a ...
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Lloyd Smith, Michael Westphall, Xiaoyu Chen, Brian Frey | P04178US
Technology
Use of Nanomaterials to Enrich Phosphopeptides for Mass Spectrometry-Based Proteomics
Proteomics is a relatively new discipline that is a large scale study of proteins. It includes systematically identifying the sequence, characterizing the structure and evaluating the function of all ...
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Song Jin, Ying Ge, Cory Nelson, Qingge Xu | P08123US02
Technology
Real-Time Tandem Mass Spectral Data Analysis for Protein Sequence Identification
Protein characterization has become an integral part of modern biology, even inspiring a new discipline known as proteomics, or the classification of proteins based on the genome of an organism. ...
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Joshua Coon, Gheorghe Craciun, Shane Hubler | P08040US
Technology
Identifying Related Peak Sets to Boost Mass Spectrometry Throughput
Tandem mass spectrometry (MS/MS) is a technique capable of identifying large numbers of proteins in complex biological samples. In the process, peptides are ionized and an initial survey scan (i.e., a...
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Joshua Coon, Michael Westphall, Derek Bailey | P120336US01
Technology
Cost-Effective Isobaric Tandem Mass Tags for High Throughput Quantitative Proteomics and Peptidomics
Mass spectrometry (MS) is a vital tool for identifying and tallying the different proteins, peptides and other molecules in a sample. To determine relative abundance, reagent tags are used to label th...
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Lingjun Li, Feng Xiang, Tyler Greer, Dustin Frost, Zhidan Liang | P110257US02
Technology
Gas-Phase Purification of Peptides Reaps Accuracy in Mass Spectrometry Quantitation
Maturing protein analysis technologies continue to elucidate life’s chemical architecture with a precision even recently unimaginable. Mass spectrometry (MS), which ionizes and fragments proteins fo...
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Joshua Coon, Michael Westphall | P110234US02
Technology
Increasing Peptide and Protein Identifications with Prioritized Mass Spectrometry
As resources shift from genome sequencing to understanding and characterizing expressed genes and protein function, reliable and rapid tools for the analysis of protein composition are increasingly vi...
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Joshua Coon, Douglas Phanstiel, Graeme McAlister | P110191US01
Technology
Mass Spectrometry Data Acquisition Method Enables More Reliable Large-Scale Protein Quantitation
Quantitative analysis in chemistry is the determination of the absolute or relative abundance of substances present in a sample. For biological samples, quantitative analysis performed via mass spectr...
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Joshua Coon, Craig Wenger, Douglas Phanstiel | P100173US02
Technology
Parallel Measurements by Fluorescence and Mass Spectrometry for Absolute Quantification of Proteins
Mass spectrometry (MS) has become the principal tool for routine identification of proteins and their post-translational modifications (PTMs). Quantification of the amounts of proteins and PTMs is req...
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Joshua Coon, Lloyd Smith, Ryan Hilger, Jason Russell, Daniel Ladror, Michael Shortreed, Mark Scalf | P100208US01
Technology
Space and Time Variant Electric Field Enhancement Improves Accuracy of Mass Spectroscopy for Large Compounds
Mass spectroscopy is an analytical technique used to identify, quantify and characterize unknown compounds based on the elemental masses that make up the compounds. The unknown particles are ion...
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Thomas (Rock) Mackie, Adam Hecht, Joseph Bisognano | P08171US