Wisconsin Alumni Research Foundation

Technology

Novel Small Molecule SIRT6 Activators/Inhibitors

The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
Learn More
John Denu, Weiping Tang | P160306US01

Technology

Compounds to Treat Hyperlipidemia and Fatty Liver Disease

Hyperlipidemia is a condition strongly associated with obesity and is an independent risk factor for the development of coronary heart disease. To help combat hyperlipidemia, the pharmaceutical indust...
Learn More
Mark Keller, Alan Attie, Sheldon Engelhorn, Nikolai Sepetov, Sergei Romanov, David Bernlohr | P110006US01

Technology

Non-Natural Peptides for Treating Diabetes

Diabetes mellitus continues to be a chronic public health issue despite the availability of injectable insulin since the 1920s. Finding alternative treatments is the subject of intense research. In re...
Learn More
Samuel Gellman, Lisa Johnson, Alan Attie, Alan Saghatelian, Mark Keller | P130310US02

WARF