The present invention provides improved methods and compositions for therapeutically controlling and/or reducing serum phosphate levels in animals and mammalian patients. The methods comprise administ...
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It is disclosed here a method for reducing phosphate absorption in a human or non-human animal subject wherein the subject consumes a diet containing phytic acid or phytate and either has or is at ris...
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A method for reducing phosphate absorption in a human or non-human animal subject at risk of developing or having developed hyperphosphatemia is disclosed. The method includes the step of administerin...
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Polypeptides, such as enzymes, antibodies, hormones and cytokines, are useful therapeutic agents. However, routes for systemically introducing such polypeptides to a subject are limited. Oral administ...
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The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
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Indole is one of the most abundant heterocycles in pharmaceuticals and bioactive natural products, such as indometacin, a non-steroid anti-inflammatory drug, and vincristine, a natural product used to...
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Hyperlipidemia is a condition strongly associated with obesity and is an independent risk factor for the development of coronary heart disease. To help combat hyperlipidemia, the pharmaceutical indust...
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Normally, digested food can be absorbed into the bloodstream in the form of sugars like glucose, which then signals pancreas beta cells to secrete more insulin. This insulin is needed to help the gluc...
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Indole is one of the most abundant heterocycles in pharmaceuticals and bioactive natural products, such as indometacin, a non-steroid anti-inflammatory drug, and vincristine, a natural product used to...
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Diabetes mellitus continues to be a chronic public health issue despite the availability of injectable insulin since the 1920s. Finding alternative treatments is the subject of intense research. In re...
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Phenylketonuria (PKU) is a genetic disorder in which an individual lacks the enzyme phenylalanine hydroxylase (PAH) that converts the amino acid phenylalanine into tyrosine.  If left untreated, t...
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The kidney filters toxins and excess nutrients from the blood. It also synthesizes the active form of vitamin D3. In patients with chronic kidney disease, levels of active vitamin D3 decline, leading ...
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