Wisconsin Alumni Research Foundation

Technology

Streamlined Design for Transferring Analytes

Polymerase chain reaction (PCR) is used to generate copies of a particular DNA sequence. The technique is common and indispensable in many research applications. Unfortunately, methods for isolating/p...
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David Beebe, Ben Casavant, David Guckenberger, Scott Berry | P130361US01

Technology

Circulating Tumor Cell Assay Using Simple Blood Draw

Circulating tumor cells (CTCs) are cells shed from tumor deposits that flow into the bloodstream. They are detected at a frequency of about one CTC per one billion surrounding blood cells. The great h...
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David Beebe, Joshua Lang, Ben Casavant, Scott Berry, Lindsay Strotman | P130171US01

Technology

Micro-Electro-Discharge Machining Method and Device

Micro-electro-discharge machining (micro-EDM) is a microfabrication technique involving the serial discharge of electrical pulses between a microelectrode and a work piece, with a simple RC circuit co...
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Yogesh Gianchandani, Kenichi Takahata | P01335US

Technology

Micromachined Scanning Thermal Probe

Scanning thermal probes hold promise for many applications, including high-resolution temperature mapping (e.g., for ULSI circuit diagnostics), topographical mapping, photothermal absorption spectrosc...
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Yogesh Gianchandani, Mo-Huang Li, Julius Wu | P01026US

Technology

Microscope Probe Having an Ultra-Tall Tip

Atomically sharp micro-fabricated tips are used in atomic force microscopy (AFM) for scanning near-field microwave microscopy (SNMM) to create an image of the tiny topography on or under a surface. Th...
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Daniel van der Weide, Yaqiang Wang | P06244US

Technology

Microwell Moat Prevents Spillover

The ability to study single cells has become indispensable, helping researchers identify characteristics and behaviors otherwise hidden using population averages. By obtaining multiple measures per ce...
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Jay Warrick, John Yin, Stephen Lindsay | P120353US01

Technology

Device Uses Air Gap for Easier Fraction Isolation

Isolating analytes from complex biological samples is one of the most crucial steps in many areas of biological research and clinical diagnostics. Paramagnetic particles (PMPs) or beads are important ...
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David Beebe, Scott Berry | P130107US01

Technology

Smoother Surfaces with Pulsed Laser Polishing

Pulsed laser polishing (PLP) helps smooth metal and other material. The technique employs lasers to irradiate a surface, melting small areas with each pulse. In these molten areas, rough surface protr...
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Frank Pfefferkorn, Xiaochun Li, Neil Duffie, Chao Ma, Venkata Madhukanth Vadali | P130168US01

Technology

Ultrasonic Welding with Real-Time Quality Control

In ultrasonic welding, work pieces are clamped between a horn and anvil and then joined using high-frequency vibration energy. Friction and heat between the surfaces causes them to soften and meld tog...
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Xiaochun Li, Hongseok Choi, Hang Li, Wayne Cai, Jeff Abell, Jingzhou Zhao | P120081US01

Technology

Patch Clamp Providing On-Chip Thermal Control

Approximately half of all diseases affect the function of ion channels in cell membranes. Testing the flow of ions and molecules through these membranes clearly is vital to drug discovery and research...
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Robert Blick | P110325US01

Technology

Atmospheric Growth of Vertically Oriented Graphene

Nano-carbon based hybrid materials possess extraordinary properties and show great promise for improved efficiency and sensitivity in a wide range of applications including capacitors, sensors, transp...
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Junhong Chen, Kehan Yu, Zheng Bo, Ganhua Lu | T130004US02

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