Wisconsin Alumni Research Foundation

Technology

Enzyme Aids Intranasal Drug Delivery

Currently, delivering drugs directly into the brain requires invasive surgery. This is because a tight cellular layer called the blood-brain barrier (BBB) not only prevents harmful substances from ent...
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Robert Thorne, Jeffrey Lochhead | P120322US02

Technology

Treatment of Fragile X Syndrome Using Nutlin-3

Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability, affecting 1 in 4,000 males and 1 in 6,000 females. It is characterized by severe learning problems, developmental...
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Xinyu Zhao, Yue Li | P150380US02

Technology

Peptides to Treat Alzheimer’s Disease

Amyloid-beta (Aβ) peptides play a crucial role in Alzheimer’s disease – they are a main component of the toxic amyloid plaques found in patients’ brains. Aβ is so dangerous because it can aggr...
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Regina Murphy, Jeffrey Johnson, Patricia Cho, Xiaomeng Lu | P140391US02

Technology

Treating Absence Epilepsy with Ganaxolone

Absence epilepsy (formerly known as ‘petit mal epilepsy’) afflicts thousands of people worldwide, many of them children. It is characterized by nonconvulsive seizures, loss of consciousness, glass...
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Mathew Jones, Chiara Cirelli, Kile Mangan, Aaron Nelson | P140051US02

Technology

New Treatment for Restenosis

Atherosclerosis (hardening of the arteries) is the leading cause of death in the United States. It can be addressed by several procedures, including angioplasty and bypass. However, when a blood vesse...
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K. Craig Kent, Shakti Goel, Lianwang Guo | P120330US02

Technology

Novel Subtype of Botulinum Toxin for Pharmaceutical Use

Clostridium botulinum produces botulinum neurotoxin (BoNT), which can cause debilitating disease but also is used to treat disorders like chronic headache, spastic muscles and strabismus. The bacteri...
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Eric Johnson, Kristin Marshall, Sabine Pellett, Marite Bradshaw | P06269US

Technology

Treating Multiple Sclerosis with UV Light

Multiple sclerosis (MS) is a chronic autoimmune disease that afflicts more than 2.5 million people worldwide. Symptoms include weakness and numbing, pain, swallowing problems, blurred vision and diffi...
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Hector DeLuca, Yanping Wang, Steven Marling | P120376US02

Technology

Anti-Anxiety Pharmaceuticals with Reduced Side Effects

According to the National Institute of Mental Health, anxiety disorders affect approximately 40 million American adults. These chronic illnesses can severely decrease a patient’s quality of life. An...
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James Cook, Qi Huang, Xiaohui He, Xiaoyan Li, Jianming Yu, Dongmei Han | T02017US

Technology

Method of Targeting Pharmaceuticals to Motor Neurons

Even though therapeutic compounds have been developed for nervous system disorders, these conditions remain difficult to treat, largely because of the difficulties associated with delivering drugs to ...
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Eric Johnson, Michael Goodnough, William Tepp, Carl Malizio | P00282US

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