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60 Results for 'Oncology'
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Technology
HYDROGEL COMPOSITIONS COMPRISING GASDERMIN D AND AN ESCRT INHIBITOR AND METHODS OF USE THEREOF
UW-Madison researchers have developed a novel approach for enhancing pyroptosis, which could prove beneficial in treating cancer. The inventors combine intracellular delivery of gasdermin with a small...
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Quanyin Hu, Zhaoting Li | P220290US02
Technology
PSMA-Targeting Ligands with Optimal Properties for Imaging and Therapy
Theranostics, a term derived from a combination of therapeutics and diagnostics, is an emerging field of medicine where specific radionuclide disease-targeting agents are used to diagnose and treat me...
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Reinier Hernandez, Anatoly Pinchuk | P210215US02
Technology
Nanoparticles For Potentiating Effects Of Radiation Therapy On Anti-Cancer Immunotherapy
The present technology from UW Madison inventors provides nanoparticles comprising a positively charged polymer (e.g., polylysine) electrostatically bound to iron oxide nanoparticles and CpG oligodeox...
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Shaoqin Gong, Zachary Morris, Ying Zhang, Raghava Sriramaneni | P210094WO01
Technology
Anti-Tumor DNA Vaccine With PD-1 and LAG-3 Pathway Blockade
The present invention by UW Madison researchers provides combination therapies and methods of treating cancer, including, cancers that are resistant to PD-1 therapy. The combination therapies describe...
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Douglas McNeel, Christopher Zahm, Jena Moseman | P210083US02
Technology
Effective and Robust Method of T Cell Expansion and Activation
Ex vivo expansion and activation of T cells are prerequisites for any form of genetically engineered T cell immunotherapy. Several expansion and activation methodologies have been developed. However, ...
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Peiman Hematti, Debra Bloom | P150198US02
Technology
Nonviral Generation of Genome-Edited CAR T Cells
Use of viral vectors for chimeric antigen receptor (CAR) T cell manufacturing constitutes a bottleneck in the supply chain for biomanufacturing and can be problematic due to: (1) batch-to-batch variab...
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Krishanu Saha, Christian Capitini, Katherine Mueller, Nicole Piscopo, Amritava Saha, Matthew Forsberg, Louise Saraspe | P200184US02
Technology
USE OF TOLL-LIKE RECEPTOR 4 AGONISTS TO TREAT INFLAMMATION AND TISSUE INJURY
The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkyl glucosaminide phosphate mole...
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Peiman Hematti, John Kink, Christian Capitini, Matthew Forsberg, Reinier Hernandez, Zachary Rosenkrans, Nicholas Hess | P200327US02
Technology
MODULAR DENDRON MICELLES FOR COMBINATION IMMUNOTHERAPY
UW-Madison researchers have developed a nanoparticle-based platform comprising targeting agents (i.e., tumor selective peptides) and active agents (e.g., immuno- and chemo-drugs). The nanopartic...
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Seungpyo Hong, Deric Wheeler | P210003WO01
Technology
Multicell Conjugates For Activating Antigen-Specific T Cell Responses
The present invention from UW Madison researchers provides in vitro derived a multicell conjugate comprising an iNKT cell and a dendritic cell (DC). The invention also provides methods of making the m...
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Jenny Gumperz, Dana Baiu | P200046US02
Technology
LPS Priming of Stromal Cells to Generate LPS-specific Exosome Educated Macrophages
Currently there are no cell therapies approved for use against acute radiation injury (ARS). Severe ARS can cause death and the only cell treatment is allogenic bone marrow transplantation (BMT). Unfo...
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Peiman Hematti, John Kink, Christian Capitini | P170215US02
Technology
Metabolic-based Methods For Modulating Gene Expression
This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentrat...
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Thomas Sutula, Avtar Roopra, Barry Schoenike | P05137US
Technology
Unimolecular Nanoparticles For Efficient Delivery Of Therapeutic Cationic Peptides
Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be u...
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Shaoqin Gong, Wei Xu, Yuyuan Wang, Fabao Liu | P170128US02
Technology
Alkylphosphocholine Analogs For Multiple Myeloma Imaging And Therapy
The inventors have discovered that certain alkylphosphocholine analogs are preferentially taken up by multiple myeloma tumor cells, as compared to non-tumor cells. The inventors have further demonstra...
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Chorom Pak, Jamey Weichert, Mario Otto, Roberta Marino, Fotios Asimakopoulos, Benjamin Titz, Kevin Kozak | P150207US03
Technology
Syndecan Peptides And Polypeptides As Inhibitors Of Vegfr2 And Vla-4
Peptides derived from amino acid residues 210 to 240 of human syndecan 1 and methods of use of such peptides are described. These peptides can inhibit activation of α4β1 integrin (also known as very...
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Alan Rapraeger, Oisun Jung | P150222US02
Technology
Amino Thiol Compounds And Compositions For Use In Conjunction With Cancer Therapy
The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are admi...
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William Fahl, Daniel Peebles, Richard Copp | P04014US
Technology
Peptide-Nanoparticle Conjugates
Described herein is a nanoparticle system including a multivalent nanoparticle core having a plurality of β-hairpin peptides conjugated thereto. Also included are pharmaceutical compositions and meth...
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Seungpyo Hong, Woo-jin Jeong | P200080US02
Technology
Synthesis Of Small Molecule Histone Deacetylase 6 Degraders, Compounds Formed Thereby, And Pharmaceutical Compositions Containing Them
Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; ...
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Weiping Tang, Ka Yang, Hao Wu, Zhongrui Zhang | P180321US05
Technology
Combination Chemotherapy For The Treatment Of Cancer
The present disclosure provides compositions, methods and kits for the treatment of cancer. Particularly, the present disclosure provides synergistic compositions comprising at least one cytotoxic rib...
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Ronald Raines, Trish Hoang | P170199US02
Technology
Novel Aryl Hydrocarbon Receptor Ligands Derived From Kynurenine
The present invention relates to novel compounds which are aryl hydrocarbon receptor (AHR) ligands and uses thereof. Methods of activating the AHR receptor in a subject are also provided. The compound...
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Yongna Xing, Seunghyeon Seok, Zhi-Xiong Ma, John Feltenberger | P170316US02
Technology
Versikine For Inducing And Potentiating An Immune Response
Disclosed are methods, kits, polypeptides, and pharmaceutical compositions for inducing an immune response in a subject, which may include a T-cell mediated immune response. The methods comprise admin...
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Fotios Asimakopoulos, Chelsea Hope | P160199US04
Technology
Oligolactic Acid Conjugates And Micelles With Enhanced Anticancer Efficacy
The present technology relates generally to oligolactic acid conjugates of paclitaxel, rapamycin, selumetinib, and other anticancer agents, micelle compositions containing such conjugates and methods ...
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Glen Kwon, Yu Tong (Tony) Tam | P160169US02
Technology
Methods Of Expanding Hematopoietic Stem Cells, Compositions, And Methods Of Use Thereof
Described herein are methods of expanding a population of hematopoietic stem cells by contacting the population of hematopoietic stem cells with an effective amount of an inhibitor of G-protein couple...
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Emery Bresnick, Xin Gao, Kirby Johnson | P160034US02
Technology
Radiohalogenated Agents For In Situ Immune Modulated Cancer Vaccination
A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound tha...
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Jamey Weichert, Paul Sondel, Anatoly Pinchuk, Zachary Morris, Mario Otto, Bryan Bednarz | P160396US02
Technology
Targeted Radiotherapy Chelates For In Situ Immune Modulated Cancer Vaccination
The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound t...
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Jamey Weichert, Paul Sondel, Anatoly Pinchuk, Zachary Morris, Mario Otto, Bryan Bednarz, Peter Carlson | P160397US02
Technology
Nanoengineered Surfaces For Cancer Biomarker Capture
Described herein is cancer biomarker, e.g., a vesicle, capture surface that includes a substrate, a first plurality of nanoparticles attached to the substrate; a plurality of bifunctional tethers, whe...
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Seungpyo Hong, Michael Poellmann | P180105US02