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68 Results for 'Oncology'
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Technology
Effective and Robust Method of T Cell Expansion and Activation
Ex vivo expansion and activation of T cells are prerequisites for any form of genetically engineered T cell immunotherapy. Several expansion and activation methodologies have been developed. However, ...
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Peiman Hematti, Debra Bloom | P150198US02
Technology
Nonviral Generation of Genome-Edited CAR T Cells
Use of viral vectors for chimeric antigen receptor (CAR) T cell manufacturing constitutes a bottleneck in the supply chain for biomanufacturing and can be problematic due to: (1) batch-to-batch variab...
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Krishanu Saha, Christian Capitini, Katherine Mueller, Nicole Piscopo, Amritava Saha, Matthew Forsberg, Louise Saraspe | P200184US02
Technology
USE OF TOLL-LIKE RECEPTOR 4 AGONISTS TO TREAT INFLAMMATION AND TISSUE INJURY
The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkyl glucosaminide phosphate mole...
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Peiman Hematti, John Kink, Christian Capitini, Matthew Forsberg, Reinier Hernandez, Zachary Rosenkrans, Nicholas Hess | P200327US02
Technology
MODULAR DENDRON MICELLES FOR COMBINATION IMMUNOTHERAPY
UW-Madison researchers have developed a nanoparticle-based platform comprising targeting agents (i.e., tumor selective peptides) and active agents (e.g., immuno- and chemo-drugs). The nanopartic...
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Seungpyo Hong, Deric Wheeler | P210003WO01
Technology
Multicell Conjugates For Activating Antigen-Specific T Cell Responses
The present invention from UW Madison researchers provides in vitro derived a multicell conjugate comprising an iNKT cell and a dendritic cell (DC). The invention also provides methods of making the m...
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Jenny Gumperz, Dana Baiu | P200046US02
Technology
LPS Priming of Stromal Cells to Generate LPS-specific Exosome Educated Macrophages
Currently there are no cell therapies approved for use against acute radiation injury (ARS). Severe ARS can cause death and the only cell treatment is allogenic bone marrow transplantation (BMT). Unfo...
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Peiman Hematti, John Kink, Christian Capitini | P170215US02
Technology
Use Of Aryl Hydrocarbon Receptor Ligand As A Therapeutic Intervention In Angiogenesis-implicated Dis
A method of treating angiogenesis-implicated disorders by selecting a subject predisposed to an angiogenesis-implicated disorder and then administering an effective amount of an endogenous aryl hydroc...
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Jiasheng Song, Hector DeLuca, Margaret Clagett-Dame, Stuart Helfand, Nasim Akhtar | P06145US
Technology
Methods For Detecting Risk Of Fatal Prostate Cancer Using Serum Calcium
A method of screening for increased risk of fatal prostate cancer in a subject comprises providing a blood sample collected from the subject, and then detecting the presence or absence of an increased...
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Halcyon Skinner, Gary Schwartz | P09131US01
Technology
Metabolic-based Methods For Modulating Gene Expression
This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentrat...
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Thomas Sutula, Avtar Roopra, Barry Schoenike | P05137US
Technology
Unimolecular Nanoparticles For Efficient Delivery Of Therapeutic Cationic Peptides
Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be u...
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Shaoqin Gong, Wei Xu, Yuyuan Wang, Fabao Liu | P170128US02
Technology
Multi-Drug Combinations That Act As Potent Radiosensitizers
Provided is a method of treatment including administering to lung, brain or esophageal cancer cells an effective amount of radiation in conjunction with a micelle composition that includes an effectiv...
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Glen Kwon, Kevin Kozak, Keishiro Tomoda | P150355US02
Technology
Syndecan Peptides And Polypeptides As Inhibitors Of Vegfr2 And Vla-4
Peptides derived from amino acid residues 210 to 240 of human syndecan 1 and methods of use of such peptides are described. These peptides can inhibit activation of α4β1 integrin (also known as very...
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Alan Rapraeger, Oisun Jung | P150222US02
Technology
Alkylphosphocholine Analogs For Multiple Myeloma Imaging And Therapy
The inventors have discovered that certain alkylphosphocholine analogs are preferentially taken up by multiple myeloma tumor cells, as compared to non-tumor cells. The inventors have further demonstra...
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Chorom Pak, Jamey Weichert, Mario Otto, Roberta Marino, Fotios Asimakopoulos, Benjamin Titz, Kevin Kozak | P150207US03
Technology
Amino Thiol Compounds And Compositions For Use In Conjunction With Cancer Therapy
The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are admi...
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William Fahl, Daniel Peebles, Richard Copp | P04014US
Technology
Peptide-Nanoparticle Conjugates
Described herein is a nanoparticle system including a multivalent nanoparticle core having a plurality of β-hairpin peptides conjugated thereto. Also included are pharmaceutical compositions and meth...
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Seungpyo Hong, Woo-jin Jeong | P200080US02
Technology
Synthesis Of Small Molecule Histone Deacetylase 6 Degraders, Compounds Formed Thereby, And Pharmaceutical Compositions Containing Them
Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; ...
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Weiping Tang, Ka Yang, Hao Wu, Zhongrui Zhang | P180321US05
Technology
Synthesis Of Small Molecule Histone Deacetylase 6 Degraders, Compounds Formed Thereby, And Pharmaceutical Compositions Containing Them
Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; ...
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Weiping Tang, Ka Yang, Hao Wu | P180321US03
Technology
Generation Of Hematopoietic Progenitor Cells From Human Pluripotent Stem Cells
Methods for generating and using hematopoietic progenitor cells are described.
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James Thomson, Jue Zhang | P180326US02
Technology
Biemamides And Related Scaffolds As Inhibitors Of Transforming Growth Factor-Beta Signaling
The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-β signaling and/or TGF-β induced epithelial mesenchymal transition...
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Timothy Bugni, Fan Zhang, Douglas Braun, Gene Ananiev, F. Michael Hoffmann | P180361US02
Technology
Antibodies Targeting Glioblastoma Stem-Like Cells And Methods Of Use Thereof
The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
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Eric Shusta, Michael Zorniak, Paul Clark, Yongku Cho, Benjamin Umlauf, John Kuo | P180018US02
Technology
Versikine For Inducing And Potentiating An Immune Response
Disclosed are methods, kits, polypeptides, and pharmaceutical compositions for inducing an immune response in a subject, which may include a T-cell mediated immune response. The methods comprise admin...
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Fotios Asimakopoulos, Chelsea Hope | P160199US04
Technology
Combination Chemotherapy For The Treatment Of Cancer
The present disclosure provides compositions, methods and kits for the treatment of cancer. Particularly, the present disclosure provides synergistic compositions comprising at least one cytotoxic rib...
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Ronald Raines, Trish Hoang | P170199US02
Technology
Novel Aryl Hydrocarbon Receptor Ligands Derived From Kynurenine
The present invention relates to novel compounds which are aryl hydrocarbon receptor (AHR) ligands and uses thereof. Methods of activating the AHR receptor in a subject are also provided. The compound...
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Yongna Xing, Seunghyeon Seok, Zhi-Xiong Ma, John Feltenberger | P170316US02
Technology
Stereocomplex Of Oligolactic Acid Conjugates In Micelles For Improved Physical Stability And Enhanced Antitumor Efficacy
The present technology relates generally to oligolactic acid conjugates and stereocomplexes of cortjugates of gemcitabine and gemcitabine derivatives, micelle compositions containing such conjugates...
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Glen Kwon, Yu Tong (Tony) Tam | P180209US02
Technology
Methods Of Controlling Red Blood Cell Production
A method of controlling red blood cell production includes contacting red blood cell precursors with a composition including zinc, a composition including an inhibitor of a zinc exporter protein, or a...
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Emery Bresnick, Nobuyuki Tanimura | P180160US02