Proteins change conformation in solution for a variety of reasons, including events such as ligand binding. Most researchers use simple and readily available optical means to measure protein conformat...
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Most biochemical interactions are studied in solutions containing dilute concentrations of molecules. However, the complexity of the cellular environment makes it difficult to compare the results of s...
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Over the last eight years, academic researchers have been developing a new set of spectroscopic techniques that are multidimensional versions of visible and infrared spectroscopies, such as two-dimens...
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Silent information regulator (SIRT) genes encode sirtuins, a highly conserved class of protein deacetylases that have been implicated in physiological processes and diseases states ranging from aging ...
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Human embryonic stem (hES) cells are capable of self-renewal, as long as they remain undifferentiated. Culture conditions, including the medium and substrate the cells are grown in, play an important ...
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Membrane proteins perform many crucial functions in vivo.  Physical characterization of these proteins, including the determination of three-dimensional crystal structures, could improve fundamen...
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Molecules that contain two functional groups of distinct reactivity can be used to link two biomolecules or to immobilize a biomolecule on a surface, such as a protein microarray. These bifunctional m...
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