Wisconsin Alumni Research Foundation

Technology

Novel Small Molecule SIRT6 Activators/Inhibitors

The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
Learn More
John Denu, Weiping Tang | P160306US01

Technology

Natural Antibiotic to Treat Clostridium Infection and More

Bacterial resistance to antibiotics is an escalating problem, especially in hospital settings. The Centers for Disease Control recently identified Clostridium difficile as posing an “urgent” healt...
Learn More
Timothy Bugni, Thomas Wyche, Douglas Braun, Jeff Piotrowski, Nasia Safdar | P140428US02

Technology

Nylon-3 Polymers Active Against Clostridium Difficile

Clostridium difficile is a Gram-positive, endospore-forming anaerobe that causes life-threatening intestinal infections. These infections result in more than 14,000 deaths and billions of dollars in h...
Learn More
Samuel Gellman, Runhui Liu, Bernard Weisblum, Shonna McBride | P150214US02

Technology

Treating Fungal Infections with New Forazoline Compounds

Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 pe...
Learn More
Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun | P130274US02

Technology

A Supply of the Antibiotic Oligomycin

Oligomycin is a highly stable macrolide antibiotic isolated from the fungus Streptomyces diastochromogenes. It is a potent inhibitor of mitochondrial ATPase and phosphoryl group transfer.
Learn More
Glenn Chambliss | P04054US

Technology

Inhibitors of Ebola and Other Filoviruses

Ebola, a negative strand RNA virus in the family Filoviridae, is among the most lethal human pathogens, causing death in 50 to 90 percent of cases. This virus is highly contagious in aerosol form and ...
Learn More
Yoshihiro Kawaoka, Shinji Watanabe, Yasuko Hatta | P09098US02

Technology

Small Molecule Therapeutics to Inhibit HPV Infection

Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens. These small DNA viruses are associated with almost all cervical cancers and 20 to 30 percent of head and neck cancers....
Learn More
Paul Ahlquist, Paul Lambert, Dohun Pyeon, Shane Pearce | P07490US02

Technology

Antibacterial Agents Using Small Molecule Macroarrays

Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually a...
Learn More
Helen Blackwell, Matthew Bowman, Jennifer Campbell Butler, Joseph Stringer | P06361US

Technology

Novel Antibacterial Small Molecules

As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
Learn More
Helen Blackwell, Matthew Bowman, Joseph Stringer | P07517US

WARF