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43 Results for 'Anti-infectives (antibacterials, antifungals, antivirals)'
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Technology
Inhibiting Quorum Sensing in Staphylococcus Epidermidis, a Health Care Pathogen
Staphylococcus epidermidis is an important Gram-negative bacterial pathogen in hospital-acquired infections, and the most common cause of infections on indwelling medical devices. The costs related to...
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Helen Blackwell, Tian Yang | P150348US02
Technology
Novel Small Molecule SIRT6 Activators/Inhibitors
The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
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John Denu, Weiping Tang | P160306US01
Technology
Natural Antibiotic to Treat Clostridium Infection and More
Bacterial resistance to antibiotics is an escalating problem, especially in hospital settings. The Centers for Disease Control recently identified Clostridium difficile as posing an “urgent” healt...
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Timothy Bugni, Thomas Wyche, Douglas Braun, Jeff Piotrowski, Nasia Safdar | P140428US02
Technology
Novel Analogs of Podophyllotoxin May Treat Cancer and Viral Infections
Podophyllotoxin is a natural product derived from a plant. Although two clinically useful glycosylated analogs have been developed for treating cancer, podophyllotoxin is difficult to synthesize, hind...
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Jon Thorson, James Watson, Jr. | P08343US
Technology
Enhanced HIV Treatments: Boronic Acid Group Improves Drug Potency
HIV infection, AIDS and AIDS-related complex (ARC) remain serious and ongoing diseases compromising the human immune system. Protease inhibitors, which interfere with the replication cycle of HIV, are...
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Ronald Raines, Ian Windsor, Michael Palte, John Lukesh | P140376US02
Technology
Better Living Through Peptides; Improved Approach to HIV Therapy
Human immunodeficiency virus (HIV) affects over 1.2 million Americans each year, with approximately 50,000 new infections per year. Current treatment includes HIV combination regimens comprising rever...
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Samuel Gellman, William Horne, Lisa Johnson | P08414US03
Technology
Nylon-3 Polymers Active Against Clostridium Difficile
Clostridium difficile is a Gram-positive, endospore-forming anaerobe that causes life-threatening intestinal infections. These infections result in more than 14,000 deaths and billions of dollars in h...
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Samuel Gellman, Runhui Liu, Bernard Weisblum, Shonna McBride | P150214US02
Technology
New and More Potent UGM Inhibitors for Treating Tuberculosis, Other Microbial Infections
Mycobacterium tuberculosis, the causative agent of tuberculosis, is responsible for eight million human infections and two million deaths worldwide each year. M. tuberculosis infections can be treated...
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Laura Kiessling, Valerie Winton, Alexander Justen | P160093US02
Technology
Treating Fungal Infections with New Forazoline Compounds
Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 pe...
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Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun | P130274US02
Technology
Treating Staph Infections, Toxic Shock Syndrome by Disrupting Bacteria Quorum Sensing
‘Staph’ infections, particularly by Staphylococcus aureus strains, can cause skin ailments and more serious conditions like heart valve inflammation and toxic shock syndrome. These strains...
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Helen Blackwell, Danielle Wittenwyler, Yiftah Tal Gan | P130070US02
Technology
Antiviral Peptides and Methods for Inducing Cellular Resistance to Infection
Influenza virus causes millions of infections each year worldwide. Human parainfluenza virus (PIV) types 1,2,3 and respiratory syncytial virus (RSV) types A and B are the major viral pathogens respons...
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Curtis Brandt, Hermann Bultmann | P03289US
Technology
A Supply of the Antibiotic Oligomycin
Oligomycin is a highly stable macrolide antibiotic isolated from the fungus Streptomyces diastochromogenes. It is a potent inhibitor of mitochondrial ATPase and phosphoryl group transfer.
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Glenn Chambliss | P04054US
Technology
Inhibitors of Ebola and Other Filoviruses
Ebola, a negative strand RNA virus in the family Filoviridae, is among the most lethal human pathogens, causing death in 50 to 90 percent of cases. This virus is highly contagious in aerosol form and ...
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Yoshihiro Kawaoka, Shinji Watanabe, Yasuko Hatta | P09098US02
Technology
Small Molecule Therapeutics to Inhibit HPV Infection
Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens. These small DNA viruses are associated with almost all cervical cancers and 20 to 30 percent of head and neck cancers....
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Paul Ahlquist, Paul Lambert, Dohun Pyeon, Shane Pearce | P07490US02
Technology
Antibacterial Agents Using Small Molecule Macroarrays
Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually a...
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Helen Blackwell, Matthew Bowman, Jennifer Campbell Butler, Joseph Stringer | P06361US
Technology
Novel Antibacterial Agents That Modulate Quorum Sensing and Are Effective at Physiological pH
Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules into the environment. When a certain nu...
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Helen Blackwell, Christine McInnis | P09045US02
Technology
Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria
Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules, including low molecular weight ligands...
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Helen Blackwell, Grant Geske, Jennifer Campbell Butler | P07404US
Technology
Novel Antibacterial Small Molecules
As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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Helen Blackwell, Matthew Bowman, Joseph Stringer | P07517US