Wisconsin Alumni Research Foundation

Technology

Nylon-3 Polymers Active Against Clostridium Difficile

Clostridium difficile is a Gram-positive, endospore-forming anaerobe that causes life-threatening intestinal infections. These infections result in more than 14,000 deaths and billions of dollars in h...
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Samuel Gellman, Runhui Liu, Bernard Weisblum, Shonna McBride | P150214US02

Technology

New Broad-Spectrum Antibiotics

The rise of antibiotic-resistant bacteria represents a potential health crisis. Some antibiotics (e.g., quinolones and fluoroquinolones) are losing their effectiveness while others simply don’t ...
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Douglas Weibel, Katherine Hurley, Katherine Faulkner | P140321US02

Technology

Treating Fungal Infections with New Forazoline Compounds

Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 pe...
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Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun | P130274US02

Technology

A Supply of the Antibiotic Oligomycin

Oligomycin is a highly stable macrolide antibiotic isolated from the fungus Streptomyces diastochromogenes. It is a potent inhibitor of mitochondrial ATPase and phosphoryl group transfer.
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Glenn Chambliss | P04054US

Technology

Inhibitors of Ebola and Other Filoviruses

Ebola, a negative strand RNA virus in the family Filoviridae, is among the most lethal human pathogens, causing death in 50 to 90 percent of cases. This virus is highly contagious in aerosol form and ...
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Yoshihiro Kawaoka, Shinji Watanabe, Yasuko Hatta | P09098US02

Technology

Small Molecule Therapeutics to Inhibit HPV Infection

Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens. These small DNA viruses are associated with almost all cervical cancers and 20 to 30 percent of head and neck cancers....
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Paul Ahlquist, Paul Lambert, Dohun Pyeon, Shane Pearce | P07490US02

Technology

Method for Modulating Microbial Quorum Sensing

Bacteria that use quorum sensing are thought to be involved in two thirds of human bacterial infections. These bacteria produce acyl-homoserine lactones (AHL), which they use to gauge population densi...
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Jo Handelsman, Bradley Borlee | P04217US02

Technology

Antibacterial Agents Using Small Molecule Macroarrays

Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually a...
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Helen Blackwell, Matthew Bowman, Jennifer Campbell Butler, Joseph Stringer | P06361US

Technology

Receptor For Bacillus anthracis Toxin

Infection with Bacillus anthracis, the spore-forming causative agent of anthrax, can result in either a generally benign, self-limiting cutaneous disease or a more serious and often fatal systemic dis...
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John Young, Kenneth Bradley, R. John Collier, Jeremy Mogridge | P00305US

Technology

Beta-Peptides with Antifungal Activity

Fungal infections, such as infections by the yeast Candida albicans, are a persistent health problem in some patient populations. Topical yeast infections affect the mouth, vagina, skin, stomach and u...
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Samuel Gellman, Sean Palecek, William Pomerantz, Amy Karlsson | P06201US

Technology

Novel Antibacterial Small Molecules

As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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Helen Blackwell, Matthew Bowman, Joseph Stringer | P07517US

Technology

Novel Antiviral Peptides Against Influenza Virus

Influenza viruses cause morbidity and mortality worldwide. In the United States, influenza is responsible for approximately 200,000 hospitalizations and 36,000 deaths each year. Two classes of antiv...
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Stacey Schultz-Cherry, Curtis Brandt, Jeremy Jones | P08294US

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