Wisconsin Alumni Research Foundation

Technology

Cyphomycin, Compositions And Uses Thereof

Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cypho...
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Cameron Currie, Timothy Bugni, Monica Pupo, David Andes, Humberto Ortega Dominguez | P180334US02

Technology

Antifungal Compounds

Compounds of formula (I) or formula (II), compositions and methods useful for treating and/or preventing a fungal infections are provided. wherein the substituents are as defined in the appended claim...
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Cameron Currie, Ethan Van Amam, Clarissa Sit, Antonio Ruzzini, Jon Clardy, Adrian Pinto-Tomas | P170089US03

Technology

Novel Small Molecule SIRT6 Activators/Inhibitors

The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
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John Denu, Weiping Tang | P160306US01

Technology

Natural Antibiotic to Treat Clostridium Infection and More

Bacterial resistance to antibiotics is an escalating problem, especially in hospital settings. The Centers for Disease Control recently identified Clostridium difficile as posing an “urgent” healt...
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Timothy Bugni, Thomas Wyche, Douglas Braun, Jeff Piotrowski, Nasia Safdar | P140428US02

Technology

Nylon-3 Polymers Active Against Clostridium Difficile

Clostridium difficile is a Gram-positive, endospore-forming anaerobe that causes life-threatening intestinal infections. These infections result in more than 14,000 deaths and billions of dollars in h...
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Samuel Gellman, Runhui Liu, Bernard Weisblum, Shonna McBride | P150214US02

Technology

Treating Fungal Infections with New Forazoline Compounds

Fungal infections range in severity from common athlete’s foot to life-threatening illness. Treatment can be very expensive. The cost of treating systemic Candida yeast infections exceeds $31,000 pe...
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Timothy Bugni, Thomas Wyche, David Andes, Douglas Braun | P130274US02

Technology

A Supply of the Antibiotic Oligomycin

Oligomycin is a highly stable macrolide antibiotic isolated from the fungus Streptomyces diastochromogenes. It is a potent inhibitor of mitochondrial ATPase and phosphoryl group transfer.
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Glenn Chambliss | P04054US

Technology

Inhibitors of Ebola and Other Filoviruses

Ebola, a negative strand RNA virus in the family Filoviridae, is among the most lethal human pathogens, causing death in 50 to 90 percent of cases. This virus is highly contagious in aerosol form and ...
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Yoshihiro Kawaoka, Shinji Watanabe, Yasuko Hatta | P09098US02

Technology

Small Molecule Therapeutics to Inhibit HPV Infection

Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens. These small DNA viruses are associated with almost all cervical cancers and 20 to 30 percent of head and neck cancers....
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Paul Ahlquist, Paul Lambert, Dohun Pyeon, Shane Pearce | P07490US02

Technology

Antibacterial Agents Using Small Molecule Macroarrays

Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually a...
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Helen Blackwell, Matthew Bowman, Jennifer Campbell Butler, Joseph Stringer | P06361US

WARF