Wisconsin Alumni Research Foundation

Technology

Novel Small Molecule SIRT6 Activators/Inhibitors

The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
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John Denu, Weiping Tang | P160306US01

Technology

Inhibitors of Ebola and Other Filoviruses

Ebola, a negative strand RNA virus in the family Filoviridae, is among the most lethal human pathogens, causing death in 50 to 90 percent of cases. This virus is highly contagious in aerosol form and ...
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Yoshihiro Kawaoka, Shinji Watanabe, Yasuko Hatta | P09098US02

Technology

Small Molecule Therapeutics to Inhibit HPV Infection

Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens. These small DNA viruses are associated with almost all cervical cancers and 20 to 30 percent of head and neck cancers....
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Paul Ahlquist, Paul Lambert, Dohun Pyeon, Shane Pearce | P07490US02

Technology

Novel Antiviral Peptides Against Influenza Virus

Influenza viruses cause morbidity and mortality worldwide. In the United States, influenza is responsible for approximately 200,000 hospitalizations and 36,000 deaths each year. Two classes of antiv...
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Stacey Schultz-Cherry, Curtis Brandt, Jeremy Jones | P08294US

WARF