The UW/VA inventor showed that hCG raises circulating sex hormone levels in a mouse model for TBI as compared to sham treated mice. The data indicated that 1) craniectomy is sufficient to induce persi...
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Clostridium botulinum produces the lethal botulinum neurotoxin (BoNT). There are several types of BoNT, and the subtype BoNT/A1 is used medically to treat muscle movement disorders and cosmetic concer...
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The present invention uses pharmaceutical preparations of Botulinum toxin to induce neurogenic atrophy to alter muscle volume and subsequently, facial contour. Reduction in lip volume is accomplished ...
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This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentrat...
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This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells.
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The present invention provides methods for treating sinus-evoked headaches using botulinum toxin injected or applied in multiple subcutaneous locations over divisions of the trigeminal nerve in soft t...
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This invention relates to a composition of botulinum based pharmaceuticals used for therapeutic and cosmetic treatment. This invention offers an improvement on the prior art by eliminating the potenti...
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A method and computer program product for suppressing the symptoms of multiple sclerosis (MS) by irradiating a subject exhibiting the symptoms with a pre-determined dose of UV-containing light from a ...
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An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed....
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This invention provides methods for reducing the extent and progression of traumatic brain injury and its deleterious sequellae specifically cognitive decline, post-traumatic epilepsy, post-traumatic ...
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Described herein are CRISPR/Cas9 constructs designed for the C-terminal truncation of human amyloid precursor protein (APP) as well as methods of making and using such a construct.
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Friedreich’s Ataxia (FRDA) is a neurodegenerative disorder without treatments to halt or reverse disease progression, affecting roughly 9,000 Americans. FRDA is caused by triplet expansion in the fi...
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Currently, delivering drugs directly into the brain requires invasive surgery. This is because a tight cellular layer called the blood-brain barrier (BBB) not only prevents harmful substances from ent...
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Friedreich’s ataxia (also referred to as FA or FRDA) is a rare but fatal autosomal recessive neurodegenerative disease. With an estimated incidence of 1 in every 40,000 people, it causes progressive...
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Fragile X Syndrome (FXS) is the most common form of inherited intellectual disability, affecting 1 in 4,000 males and 1 in 6,000 females. It is characterized by severe learning problems, developmental...
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Sleep apnea affects an estimated 18 million American adults annually. People with sleep apnea can develop conditions such as systemic and pulmonary hypertension, metabolic syndrome, insomnia, neuro-in...
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Amyloid-beta (Aβ) peptides play a crucial role in Alzheimer’s disease – they are a main component of the toxic amyloid plaques found in patients’ brains. Aβ is so dangerous because it can aggr...
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Absence epilepsy (formerly known as ‘petit mal epilepsy’) afflicts thousands of people worldwide, many of them children. It is characterized by nonconvulsive seizures, loss of consciousness, glass...
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Clostridium botulinum produces botulinum neurotoxin (BoNT), which can cause debilitating disease but also is used to treat disorders like chronic headache, spastic muscles and strabismus. The bacteri...
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Multiple sclerosis (MS) is a chronic autoimmune disease that afflicts more than 2.5 million people worldwide. Symptoms include weakness and numbing, pain, swallowing problems, blurred vision and diffi...
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According to the National Institute of Mental Health, anxiety disorders affect approximately 40 million American adults. These chronic illnesses can severely decrease a patient’s quality of life. An...
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Neuropathic pain encompasses a wide range of painful conditions of diverse origins, including diabetic neuropathy, post herpatic neuralgia, post-surgical nerve injuries and many others. Currently ther...
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