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51 Results for 'Diagnostics & monitoring tools'
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Technology
Method and Device to Screen and Sort Cancer Immunotherapy Cells
A new cancer treatment being studied at a few major centers including UW Health is CAR T (Chimeric Antigen Receptor T cell) therapy. CAR T therapy uses a patient's own cells and 'reengineers' them to ...
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Melissa Skala, Alexandra Walsh | P180292US02
Technology
Algorithms to Classify T Cell Activation by Autofluorescence Imaging
The importance of T cells in immunotherapy is driving the development of technologies to better characterize T cells and improve therapeutic efficacy. One specific objective is assessing antigen-induc...
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Melissa Skala, Anthony Gitter, Zijie Wang, Alexandra Walsh | P190306US02
Technology
Porous Silicon Nanomembranes for the Rapid Separation of Macromolecules by Size and Shape
The separation or isolation of proteins from a heterogeneous mixture is a common practice in scientific experimentation and the manufacturing of biologic reagents. Commercially available kits and cur...
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Gokul Gopalakrishnan, Mark Levenstein | T180038WO01
Technology
Liquid Crystal-Based Assay for Rapid and Precise Detection of Endotoxin in the Presence of Masking Agents
Bacterial contamination is a major risk in biologics manufacturing and the presence of endotoxin, an outer membrane component of Gram-negative bacteria, is vigorously tested for in protein and DNA/RNA...
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Nicholas Abbott, Christopher Murphy, Jugal Gupta, I-Hsin Lin | P09241US02
Technology
Noninvasive Assay for Bovine Embryo Quality
Selection intensity for higher milk production in dairy cattle has contributed to a decline in fertility, posing a challenge to dairy producers. Despite technological advances, the pregnancy rate of c...
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Hasan Khatib, Jenna Kropp | P150131US02
Technology
Predicting Glucoregulatory Dysfunction
The term glucoregulatory dysfunction covers a spectrum of disorders from insulin resistance to prediabetes and diabetes. Problems associated with glucoregulatory dysfunction and obesity dominate healt...
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Dhanansayan Shanmuganayagam, Rozalyn Anderson, Ricki Colman, James Ntambi, Mary Lindstrom, Michael Polewski, Maggie Burhans | P150057US02
Technology
Implantable Cancer Drug Delivery Device Signals the Future of Personalized Medicine
Cancer treatment planning remains an ongoing challenge to oncologists and patients alike, with each cancer being genetically unique and requiring personalized approaches. Greater outcome success will ...
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David Beebe, Mark Burkard, Jay Warrick, David Guckenberger, Lee Wilke | P150255US01
Technology
Identification of Disease Characteristics Using Isotope Ratios in Breath
UW-Madison researchers previously described a method of determining whether or not an animal is suffering from a catabolic change by sampling isotope changes in breath or blood.
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Warren Porter, Mark Cook, Fariba Assadi-Porter, Daniel Butz | P05416US
Technology
Detection of the Catabolic State by Determining the Rate of Systemic Oscillations in Carbon Isotope Ratios
The catabolic state refers to the condition where the body uses stores of carbohydrates, amino acids or fats as a source of energy for maintenance. The catabolic state may be induced by infection, dis...
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Hamid Eghbalnia, Mark Cook, Warren Porter, Daniel Butz | P09010US
Technology
Otoscope Providing Improved Ear Canal Access
An otoscope is a classic, handheld medical device that allows a doctor to look into the ear canal and tympanic membrane (eardrum). This is important for diagnosing ear infections, membrane ruptures an...
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James Berbee, Azita Hamedani, Gregory Rebella | P140406US01
Technology
Biomarkers for Detecting Prostate Cancer
Prostate cancer is the second most common cancer in American men, causing more than 27,000 deaths every year. An estimated one man in seven will be diagnosed with prostate cancer during his lifetime.
...
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David Jarrard, Bing Yang | P130258US03
Technology
Bedside Diagnosis of Swallowing Disorders
Approximately 15 million Americans suffer from a swallowing disorder (dysphagia). People with acid reflux, a neurological disorder or cancer of the head and neck are particularly at risk. The leading ...
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Matthew Hoffman, Jack Jiang, Timothy McCulloch, Zhixian Geng | P130237US01
Technology
Enhancing Light-Based Tissue Diagnostics by Dimpled Waveguide
Compact solid-state LED/LD (light-emitting diode) light sources are by their nature near-point sources. Applications that take advantage of these highly efficient, spectrally engineered light sources ...
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Leon McCaughan, Thomas Kuech, Christopher Zenner, Cedric Meyers | P100229US01
Technology
One-Step DNA Extraction from Dried Blood Spots for Newborn Screening
Newborn screening is the practice of testing newborns for certain harmful or potentially fatal disorders that are not otherwise apparent at birth. Generally, blood drops are obtained from the heel, fi...
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Mei Baker | P100253US02
Technology
Algorithm Improves Resolution of Time-Frequency Analysis for Medical Diagnostics, Telecommunications
Time-frequency analysis involves detecting when oscillations of certain frequencies turn on and off. This kind of analysis is useful in nearly every field of science and engineering. The traditional a...
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David Hsu, Murielle Hsu, Gregory Worrell | P100227US01
Technology
Optimizing Probes to Improve Spectroscopic Measurement in Turbid Media
Fiber optic probes can be used for spectroscopic measurement of tissue. A fiber optic tube emits light on one side of the tissue that is absorbed and measured on the other side by fiber optic detector...
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Gregory Palmer, Nirmala Ramanujam | P06032US
Technology
Novel Assay for Measuring Stress-Induced CREB Phosphorylation
CREB is a transcription factor that has been implicated as a critical regulator of neuronal function and survival. Knockout mice lacking CREB exhibit a disease similar to ataxia telangiectasia, a neur...
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Randal Tibbetts, Yuling Shi | P04048US
Technology
Integrated, Miniaturized Fiber Optic Probe for Light-Based Diagnostics
Light-based diagnostics are used to create images of human tissue to detect the development of diseases like cancer. The popularity of light-based diagnostics is growing due to their non-intrusive nat...
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Thomas Kuech, Nirmala Ramanujam, Leon McCaughan | P09149US
Technology
Computational Algorithms for Identifying, Suppressing and Reversing Epilepsy
Epileptogenesis, or the occurrence of spontaneous seizures, is considered to be a learned response due to brain plasticity. The development of the condition requires circuits in the brain to pos...
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David Hsu, Murielle Hsu, John Beggs | P08298US
Technology
Phospholipase Activity Provides a Simple Test for Systemic Inflammation in Acute and Chronic Disease
The inflammatory response plays a role in illnesses from injury to infections to allergies. Initiation of inflammation involves the activation of immune cells that trigger a cascade of events le...
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Keith Meyer, Francis Tsao | P02007US
Technology
Method for Extraction of Optical Properties from Diffuse Reflectance Spectra
Diffuse reflectance spectroscopy can be used to measure tissue absorption and scattering, which reflect the intrinsic physiological and structural properties of tissue respectively. This technique can...
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Nirmala Ramanujam, Gregory Palmer | P05045US
Technology
Improved Method of Fluorescence Spectroscopy using Monte Carlo Simulation for Medical Diagnostics
The early detection of disease or malignancy can greatly increase the probability of full recovery, especially in the case of cancers. Optical diagnostic techniques, such as diffuse reflectance ...
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Nirmala Ramanujam, Gregory Palmer | P06332US
Technology
Depth-Resolved Reflectance Instrument
Phsyicians often use microscopic visual inspection followed by biopsy to detect cancer; however, this method is limited in many ways. Optical techniques are a promising alternative that allows clinici...
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Nirmala Ramanujam, Liu Quan | P05015US
Technology
Non-Invasive Diagnosis and Evaluation of Disease
A complex network of biochemical processes underlies living systems. As these biochemical processes change, there is a corresponding change in the biological substances that are consumed or produced. ...
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Warren Porter, Fariba Assadi-Porter, Mark Cook, Hamid Eghbalnia, Marco Tonelli, Daniel Butz | P05420US
Technology
Imaging Spectrometer for Early Detection of Skin Cancer
Skin cancer detection is typically identified via standard visual inspection. Skin patches with asymmetrical outlines, irregular borders, mottled color or a diameter greater than six millimeters are a...
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Andrew Sheinis | P06477US