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46 Results for 'DNA & RNA tools'
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Technology
Inorganic Coatings For The Enhancement Of Chemical Transfection
William Murphy, Andrew Khalil, Xiaohua Yu, Krishanu Saha, Jared Carlson-Stevermer, Benjamin Steyer | P150078US01
Technology
Systems And Methods For Identifying Sequence Information From Single Nucleic Acid Molecule Measurements
David Schwartz, Subhrangshu Nandi, Michael Newton | P180056US02
Technology
Vector For Gene Silencing And Replacement And Methods Of Use Thereof
Erik Dent, Matthew Millette | P180170US02
Technology
Method To Enhance Screening For Homologous Recombination In Genome Edited Cells Using Recombination-Activated Fluorescent Donor Delivery Vector
Mark Burkard, David Thompson | P180200US02
Technology
System And Method For En Masse Patterning Of Molecule Structures
David Schwartz, Kristy Kounovsky-Shafer, Juan Hernandez-Ortiz, Konstantinos Potamousis, Kyubong Jo, Juan DePablo, Theo Odijk | P170209US02
Technology
A Method To Determine The Throughput Speed Of A Pore
Robert Blick, Paul Gwozdz, Abhishek Bhat | P160202US02
Technology
Methods And Systems For Isolating And Identifying Nucleic Acid From A Plurality Of Microorganisms And Viruses
Tony Goldberg, Samuel Sibley | P160266US02
Technology
High-Density Nucleic Acid Arrays On Polyester Substrates
David Lynn, Matthew Holden, Matthew Carter, Lloyd Smith | P170367US02
Technology
Nanocapsule Delivery System For Ribonucleoproteins
With the explosion of interest in using the CRISPR/Cas9 system for gene editing, there is a strong focus on developing tools for delivering the CRISPR machinery safely and efficiently into cells. Exis...
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Shaoqin Gong, Krishanu Saha, Guojun Chen, Amr Abdeen, Yuyuan Wang, Ruosen Xie | P170376US02
Technology
Nuclease Inhibitors and Methods for Their Use
Biochemical research and biotechnology rely on nucleic acids; however, nucleic acids frequently encounter nucleases that can negatively affect experiments. Although nuclease inhibitors are often used ...
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Ronald Raines, Bryan Smith, David Lynn, Matthew Soellner | P05096US
Technology
S1mplex: A New Tool for Precision Gene Editing
New tools for human gene editing are rapidly advancing all sectors of biomedicine from basic biology to somatic gene therapy in the clinic. Precise editing of DNA sequences in the human genome can be ...
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Krishanu Saha, Jared Carlson-Stevermer, Amr Abdeen, Lucille Kohlenberg | P170309US02
Technology
Microfluidic Device for Rapid Nucleic Acid Isolation and Purification
Extraction and isolation of nucleic acids from biological samples is an essential prerequisite for further amplification, detection and quantification of specific genetic sequences. The first step in ...
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David Beebe, Scott Berry | P100050US01
Technology
Titin Minigene: Cardiac Research Tool
Titin is a sarcomeric protein expressed primarily in striated muscles. It is responsible for maintaining the structure and biomechanical properties of muscle cells.
In the heart, cardiac titin under...
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Marion Greaser, Shijun Li, Wei Guo | P170288US01
Technology
Streamlined Design for Transferring Analytes
Polymerase chain reaction (PCR) is used to generate copies of a particular DNA sequence. The technique is common and indispensable in many research applications. Unfortunately, methods for isolating/p...
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David Beebe, Ben Casavant, David Guckenberger, Scott Berry | P130361US01
Technology
Poly(UG) Polymerase: A Useful New RNA Tool
Enzymes called ribonucleotidyl transferases (NTases) add nucleotides to the ends of RNAs. At present only a few such enzymes are known, such as poly(A) polymerases and poly(U) polymerases. The selecti...
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Marvin Wickens, Melanie Preston | P140268US02
Technology
Nanopore Antennas for Ultrahigh Speed DNA Sequencing
‘Nanopore sequencing’ allows a single molecule such as DNA to be analyzed without conventional tools like chemical labels or costly optical instruments. In the process, DNA strands and a stream of...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P140109US01
Technology
Faster, Cheaper DNA Synthesis
Synthesizing DNA and genes is an important tool in biotechnology. It has become commonplace to synthesize short DNA chains, called oligonucleotides, on a substrate and use these as building blocks to ...
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Michael Sussman, Kathryn Richmond, Matt Rodesch | P04400US02
Technology
DNA Synthesis with Error Reduction
Synthesizing DNA is an important part of biotechnology but current methods are useful only for relatively short gene sequences. Researchers are forced to construct larger genes through time-consuming ...
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Peter Belshaw, Michael Sussman, Franco Cerrina, James Kaysen, Brock Binkowski, Kathryn Richmond | P05071US
Technology
Synthesis of High-Density Oligomer Microarrays
To save time and costs, many alternatives to conventional DNA sequencing have been proposed. One approach utilizes an array of oligonucleotide probes (short nucleic acid chains) synthesized by photoli...
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Franco Cerrina, Viktoriya Golovkina | P05183US
Technology
New Protein Production Strategy for Plants
In animals, plants and other eukaryotic organisms, typically one protein is translated from each mRNA. Usually, translation can start only at one end of the mRNA strand. In contrast, several viruses ...
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Aurelie Rakotondrafara, Jincan Zhang | P140069US02
Technology
Gene Editing Tool Uses New Enzyme
Genome editing has proven difficult in cells, especially mammalian cells. One way to improve efficiency is to introduce a double-strand break (DSB) in the desired DNA region. These DSBs stimulate cell...
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James Thomson, Zhonggang Hou, Yan Zhang, Rakhi Rajan, Erik Sontheimer, Alfonso Mondragón | P130315US02
Technology
Computer-Based Determination of Haplotype
Humans are diploid organisms whose (non-sex) cells contain two copies of each chromosome – one from each parent. Each of these two copies may be distinguished by genetic variations such as insertion...
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Tom Anantharaman, Bud Mishra, Will Casey | P05170US
Technology
Device Uses Air Gap for Easier Fraction Isolation
Isolating analytes from complex biological samples is one of the most crucial steps in many areas of biological research and clinical diagnostics. Paramagnetic particles (PMPs) or beads are important ...
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David Beebe, Scott Berry | P130107US01
Technology
Assembly of Full-Length Genes from DNA Arrays
The ability to chemically synthesize single-stranded oligonucleotides has had a profound impact on research and medicine. Yet existing strategies have their limitations. One critical limitation is the...
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Lloyd Smith, Cheng-Hsien Wu | P120014US02
Technology
Regulating Stem Cell Behavior with High Throughput Mineral Coatings
Transfection is the process of introducing nucleic acids into cells. Two main strategies are viral (utilizing viruses as vectors) and non-viral. Non-viral methods are less efficient but attractive for...
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William Murphy, Siyoung Choi, Xiaohua Yu | P110350US01