Wisconsin Alumni Research Foundation

Technology

Neoglycorandomization and Digitoxin Analogs

Many of the compounds used in drug discovery by pharmaceutical companies are glycosylated bacterial secondary metabolites. A glycosylated metabolite consists of a central core structure (aglycon) and ...
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Jon Thorson, Joseph Langenhan | P04455US

Technology

One-Step Synthesis of Diazaphosphacycles

Phosphines have many commercial and industrial uses as attachments to rare earth metal catalysts, including specialized uses in asymmetric hydrogenation and other catalytic transformations. However, c...
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Clark Landis, Wiechang Jin, Jonathan Owen, Thomas Clark | P01419US

Technology

Novel Antibacterial Small Molecules

As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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Helen Blackwell, Matthew Bowman, Joseph Stringer | P07517US

Technology

Type 1 Polyketide Synthase Extender Units

Microorganisms produce a variety of biologically active secondary metabolites, which display a range of useful antibiotic and immunosuppressant activities. One class of secondary metabolites, known as...
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Michael Thomas, Jo Handelsman, Yolande Chan, Angela Podevels | P06464US

WARF