Mass spectrometry is a highly selective and quantitative technique that is widely used to determine the chemical composition of a sample. Applications of this analytical tool include measuring isotope...
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The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Mass spectrometry is a broadly applicable analysis tool for detecting and characterizing molecules and other chemical species, including complex mixtures of biomolecules such as peptides, proteins or ...
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Mass spectrometers are analytical instruments that can precisely measure the mass of molecules to determine their composition and identity. Generally, the molecules are ionized and then accelerated by...
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In the past decade, cataloguing the thousands of proteins present in a cell using mass spectrometry (MS) has matured into a procedure both deeply vital and straightforward. Yet discovering how such mo...
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Determining the amino acid sequence of any given protein or polypeptide is a formidable task. The first major technology to emerge for this purpose was the Edman degradation method, which sequences a ...
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Protein characterization has become an integral part of modern biology, even inspiring a new discipline known as proteomics, or the classification of proteins based on the genome of an organism. ...
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Proteomics is a relatively new discipline that is a large scale study of proteins. It includes systematically identifying the sequence, characterizing the structure and evaluating the function of all ...
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Tandem mass spectrometry (MS/MS) is a technique capable of identifying large numbers of proteins in complex biological samples. In the process, peptides are ionized and an initial survey scan (i.e., a...
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Mass spectrometry (MS) is a vital tool for identifying and tallying the different proteins, peptides and other molecules in a sample. To determine relative abundance, reagent tags are used to label th...
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Maturing protein analysis technologies continue to elucidate life’s chemical architecture with a precision even recently unimaginable. Mass spectrometry (MS), which ionizes and fragments proteins fo...
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As resources shift from genome sequencing to understanding and characterizing expressed genes and protein function, reliable and rapid tools for the analysis of protein composition are increasingly vi...
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Quantitative analysis in chemistry is the determination of the absolute or relative abundance of substances present in a sample. For biological samples, quantitative analysis performed via mass spectr...
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Mass spectrometry (MS) has become the principal tool for routine identification of proteins and their post-translational modifications (PTMs). Quantification of the amounts of proteins and PTMs is req...
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Mass spectroscopy is an analytical technique used to identify, quantify and characterize unknown compounds based on the elemental masses that make up the compounds.  The unknown particles are ion...
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Mass spectrometers are analytic instruments that precisely measure the mass of molecules, and therefore may be used to determine composition and molecule identity based on mass data. Generally, the mo...
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Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry is commonly used to identify and characterize proteins and to sequence DNA. A key step in this process involves creating sample sp...
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Protein characterization has become an integral part of modern biology, even inspiring a new discipline known as proteomics. Mass spectrometry (MS) is the most widely used technique to characterize pr...
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Analysis by mass spectrometry requires that molecules first be converted to gas-phase ions. Converting small molecules into ions is straightforward; however, it was not possible to ionize large molecu...
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Mass spectrometry is a sensitive and selective analytical tool for detecting and characterizing almost any species capable of forming an ion in the gas phase. However, mass spectrometry is limited in ...
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Electrospray ionization (ESI) mass spectrometry holds significant potential for selectively, quickly and sensitively analyzing complex mixtures of large molecular weight biomolecules, such as oligonuc...
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Analysis by mass spectrometry requires that molecules first be converted to gas-phase ions. Converting small molecules into ions is straightforward; however, ionizing large molecules, such as DNA, was...
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Electrospray ionization (ESI) mass spectrometry holds significant potential for selectively, quickly and sensitively analyzing complex mixtures of large molecular weight biomolecules, such as oligonuc...
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Mass spectroscopy is a widely used technique for detecting and analyzing molecules, including biochemical entities such as amino acids, proteins, short nucleic acids, metabolites and other small molec...
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