Wisconsin Alumni Research Foundation

Technology

Research Tool for Protein Conformation Analysis

The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Michael Sussman, Juda Shohet, Faraz Choudhury, Joshua Blatz, Benjamin Minkoff, Daniel Benjamin | P160180US02

Technology

New Mass Spectrometry Detector Uses Optically Active Membrane

Mass spectrometers are analytical instruments that can precisely measure the mass of molecules to determine their composition and identity. Generally, the molecules are ionized and then accelerated by...
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Robert Blick, Jonathan Rodriguez, Hyunseok Kim, Zlatan Aksamija, Wolfgang Hansen, Christian Heyn | P140174US01

Technology

Faster Gas-Phase Protein Sequencing

Determining the amino acid sequence of any given protein or polypeptide is a formidable task. The first major technology to emerge for this purpose was the Edman degradation method, which sequences a ...
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Lloyd Smith, Michael Westphall, Xiaoyu Chen, Brian Frey | P04178US

Technology

Inductive Detection for Mass Spectrometry

Mass spectrometry is a sensitive and selective analytical tool for detecting and characterizing almost any species capable of forming an ion in the gas phase. However, mass spectrometry is limited in ...
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Lloyd Smith, Michael Westphall | P01368US

Technology

Piezoelectric Charged Droplet Source for Mass Spectrometry

Electrospray ionization (ESI) mass spectrometry holds significant potential for selectively, quickly and sensitively analyzing complex mixtures of large molecular weight biomolecules, such as oligonuc...
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Lloyd Smith, William Berggren, Michael Westphall, Mark Scalf | P01294US

Technology

Droplet Ion Source for Mass Spectrometry

Electrospray ionization (ESI) mass spectrometry holds significant potential for selectively, quickly and sensitively analyzing complex mixtures of large molecular weight biomolecules, such as oligonuc...
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Lloyd Smith, Michael Westphall, William Berggren | P01365US

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