UW-Madison researchers have developed a phenylglyoxal-based alkyne (PGA) chemical probe exhibits a high specificity towards protein citrullination sites and offers compatibility with various azide-con...
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UW-Madison researchers have developed an improved covalent labeling system for use in protein footprinting. The innovation of the present disclosure advances a currently existing technology -- a coval...
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UW-Madison and Morgridge researchers have developed new methods and systems for complete structural characterization of biological samples. The researchers combined mass spectrometry technologies with...
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UW-Madison researchers have developed a high throughput peptide mapping platform by combining a plate-based sample preparation method with direct injection MS analysis. Protein samples are cleaned, re...
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UW-Madison researchers have developed a novel type of mass defect-based chemical tag for use in quantitative mass spectrometry analyses of proteins, peptides, glycans and metabolites. Mass defect-base...
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UW-Madison researchers have developed a nonionic cleavable surfactant (NCS) for mass spectrometry (MS)-based proteomics and analysis. Specifically, NCS was designed and synthesized to include a cleava...
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UW-Madison researchers have developed a set of novel isobaric chemical tags, DiLeu-Biotin-Azide (DBA), that could be useful in proteomics, particularly quantification of post translational modificatio...
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UW-Madison researchers developed a new process for preparing proteins, lipids, and metabolites for MS-based multi-omics. The process is based on an monophasic extraction solvent (e.g., n-butanol) that...
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Single particle cryo-electron microscopy (cryo-EM) is a powerful tool for providing 3-D structural information on non-crystalline specimens. Cryo-EM approaches atomic level resolution, enabling many n...
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Single particle cryo-electron microscopy is a powerful tool for providing 3-D structural information on non-crystalline specimens. Cryo-EM approaches atomic level resolution, enabling many new biologi...
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Single particle cryo-electron microscopy (cryo-EM) is a powerful tool for providing 3-D structural information on non-crystalline specimens. Cryo-EM approaches atomic level resolution, enabling many n...
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UW-Madison researchers have developed a novel mass spectrometry (MS)-based method for simultaneous qualitative and quantitative protein citrullination analysis from biological and clinical samples. Th...
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The invention provides methods, systems and algorithms for identifying high-resolution mass spectra. In some embodiments, an analyte is ionized and analyzed using high-resolution mass spectrometry (MS...
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Described herein are methods and systems related to the use of the pre-existing ion injection pathway of a mass spectrometer to perform beam-type collision-activated dissociation, as well as other dis...
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The invention provides methods, and related devices and device components, for detecting, sensing and analyzing analytes in samples. In some aspects, the invention provides methods, and related device...
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The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from...
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The present invention provides a set of novel isobaric chemical tags, also referred herein as SUGAR (Isobaric Multiplex Reagents for Carbonyl Containing Compound). These labeling tags are compact and ...
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Mass spectrometry is a broadly applicable analysis tool for detecting and characterizing molecules and other chemical species, including complex mixtures of biomolecules such as peptides, proteins or ...
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The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Mass spectrometry is a highly selective and quantitative technique that is widely used to determine the chemical composition of a sample. Applications of this analytical tool include measuring isotope...
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Mass spectrometers are analytical instruments that can precisely measure the mass of molecules to determine their composition and identity. Generally, the molecules are ionized and then accelerated by...
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In the past decade, cataloguing the thousands of proteins present in a cell using mass spectrometry (MS) has matured into a procedure both deeply vital and straightforward. Yet discovering how such mo...
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Proteomics is a relatively new discipline that is a large scale study of proteins. It includes systematically identifying the sequence, characterizing the structure and evaluating the function of all ...
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Protein characterization has become an integral part of modern biology, even inspiring a new discipline known as proteomics, or the classification of proteins based on the genome of an organism.  MS ...
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Tandem mass spectrometry (MS/MS) is a technique capable of identifying large numbers of proteins in complex biological samples. In the process, peptides are ionized and an initial survey scan (i.e., a...
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