Wisconsin Alumni Research Foundation

Technology

Methods For Preventing And Attenuating Hyperphosphatemia

It is disclosed here a method for reducing phosphate absorption in a human or non-human animal subject wherein the subject consumes a diet containing phytic acid or phytate and either has or is at ris...
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Mark Cook, Keith Crawford, Erica Hellestad, Martin Petkovich, Christian Helvig | P06481US

Technology

Methods And Compositions For Phosphate Binding

The present invention provides improved methods and compositions for therapeutically controlling and/or reducing serum phosphate levels in animals and mammalian patients. The methods comprise administ...
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Hector DeLuca, Katarzyna Barycka, Lori Plum, Julia Zella, Margaret Clagett-Dame | P08110US

Technology

Novel Small Molecule SIRT6 Activators/Inhibitors

The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
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John Denu, Weiping Tang | P160306US01

Technology

Compounds to Treat Hyperlipidemia and Fatty Liver Disease

Hyperlipidemia is a condition strongly associated with obesity and is an independent risk factor for the development of coronary heart disease. To help combat hyperlipidemia, the pharmaceutical indust...
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Mark Keller, Alan Attie, Sheldon Engelhorn, Nikolai Sepetov, Sergei Romanov, David Bernlohr | P110006US01

Technology

Non-Natural Peptides for Treating Diabetes

Diabetes mellitus continues to be a chronic public health issue despite the availability of injectable insulin since the 1920s. Finding alternative treatments is the subject of intense research. In re...
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Samuel Gellman, Lisa Johnson, Alan Attie, Alan Saghatelian, Mark Keller | P130310US02

WARF