G protein-coupled receptors (GPCRs) are the targets of many current therapeutic agents. As they can adopt multiple activated states, there is increasing interest in synthetic molecules that display al...
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Clostridium botulinum produces botulinum neurotoxin (BoNT), which can cause debilitating disease but also is used to treat disorders like chronic headache, spastic muscles and strabismus. Several di...
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The proper functioning of cells depends on information traveling from the extracellular environment to the cytoplasm. Most signals must be conveyed via proteins that span the cellular membrane. Many o...
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Vitamin D (1,25-dihydroxyvitamin D3) is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. An important class of vitamin D analogs, the 19-nor-...
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Ligament healing is a complex problem that is influenced by inflammatory cell responses, extracellular matrix remodeling and chemical mediators. Healing potential varies widely among ligaments, with t...
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Joint disease results in huge economic costs and can significantly reduce the quality-of-life of people who suffer from it. Pain, inflammation, and instability of the joint are common. Treatment is ge...
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No effective therapy currently exists for the most common and severe form of muscular dystrophy disease, Duchenne Muscular Dystrophy (DMD). This disease, which is characterized by the weakening of vol...
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