Disclosed are a method and a corresponding pharmaceutical composition for treating damaged cartilage and subchondral bone. Neurogenic compounds in general and neuropeptides in particular have been fou...
Learn More

The invention is related to preparation of botulinum toxin A6 and methods of use.
Learn More

X-linked hypophosphatemia (XLH) is a genetic type of rickets/osteomalacia marked by progressively severe skeletal abnormalities and growth retardation. It is a renal phosphate wasting disorder, which ...
Learn More

Clostridium botulinum produces botulinum neurotoxin (BoNT), which can cause debilitating disease but also is used to treat disorders like chronic headache, spastic muscles and strabismus. Several di...
Learn More

The proper functioning of cells depends on information traveling from the extracellular environment to the cytoplasm. Most signals must be conveyed via proteins that span the cellular membrane. Many o...
Learn More

Vitamin D (1,25-dihydroxyvitamin D3) is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. An important class of vitamin D analogs, the 19-nor-...
Learn More

Ligament healing is a complex problem that is influenced by inflammatory cell responses, extracellular matrix remodeling and chemical mediators. Healing potential varies widely among ligaments, with t...
Learn More

Joint disease results in huge economic costs and can significantly reduce the quality-of-life of people who suffer from it. Pain, inflammation, and instability of the joint are common. Treatment is ge...
Learn More

No effective therapy currently exists for the most common and severe form of muscular dystrophy disease, Duchenne Muscular Dystrophy (DMD). This disease, which is characterized by the weakening of vol...
Learn More