Wisconsin Alumni Research Foundation

Technology

Novel Small Molecule SIRT6 Activators/Inhibitors

The epigenetic modifier SIRT6 is of the sirtuin class of proteins. In transgenic mice, increased SIRT6 expression lowers LDL and triglyceride levels, improves glucose tolerance and increases mitochond...
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John Denu, Weiping Tang | P160306US01

Technology

Synstatin “SSTNI/V” Disrupts Cancer Growth

Leading UW–Madison oncologists previously showed that the matrix receptor syndecan-1 (Sdc1/CD138) – a matrix receptor highly expressed in multiple myeloma – captures and activates multiple cell ...
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Alan Rapraeger, DeannaLee Beauvais, Oisun Jung | P160224US02

Technology

TTNPB Analogs Useful for Preventing or Treating Cancer

Retinoic acid and a number of its analogs have shown some ability to prevent and treat cancer. One of the most potent is 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1-propenyl]benz...
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Margaret Clagett-Dame, Robert Curley, Michael Collins, Victoria Abzianidze | P05114US

Technology

Inhibiting Metadherin/SND1 Interaction to Treat Cancer

Metadherin (MTDH; also called AEG1 or LYRIC) is a pro-metastasis gene implicated in many types of cancer. The gene is overexpressed in more than 40 percent of primary tumors and is linked to breast ca...
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Yongna Xing, Liling Wan, Yibin Kang, Feng Guo | P140424US02

Technology

Warfarin Promoter

Warfarin is a “first-generation” anticoagulant that has been widely used as a multiple feeding rodenticide for more than 60 years. The prolonged use of warfarin as a rodenticide has, according to ...
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David Lewis, Michael Caldwell | T100001US02

Technology

Increasing Red Blood Cell Production

Maintaining an adequate supply of oxygen to tissue is necessary for survival. The oxygen-carrying capacity of blood is governed by the concentration of red blood cells (erythrocytes). It is critical t...
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Emery Bresnick, Yoon A Kang, Skye McIver | P130326US02

Technology

Treating Iron Overload with Block Copolymers

Iron overload or hemochromatosis is a disease marked by an accumulation of iron in the blood. It typically occurs in subjects (e.g., anemia patients) receiving chronic infusions of red blood cells. Th...
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May Xiong, Zhi Liu, Yan Wang | P140395US02

Technology

Synstatin “SSTNEGFR” Fights Cancer

EGFR (epidermal growth factor receptor) exists on the cell surface and is a member of a family of closely related receptor tyrosine kinases. Overexpression of EGFR can result in cancer. In particular,...
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Alan Rapraeger | P120300US03

Technology

Synstatin “SSTNHER2” Fights Cancer

Overexpression of a protein called HER2 (Human Epidermal Growth Factor Receptor 2) is implicated in about 30 percent of breast cancers, including certain aggressive forms. This protein (known more spe...
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Alan Rapraeger | P120259US03

Technology

Provoking Anti-Tumor Immune Response with Rhamnose

One promising approach to cancer treatment is to leverage the immune system. Specifically, tumors can be ‘tagged’ with foreign antigens that attract the body’s defensive antibodies. The antibodi...
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Laura Kiessling, Rachael Sheridan, Jonathan Hudon | P120290US02

Technology

Vitamin D Analogs for Treating Bone Cancers and Diseases

The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
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Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Izabela Sibilska-Kaminski, Rafal Sicinski | P100358US03

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