Wisconsin Alumni Research Foundation

Technology

Model System for Identifying Anti-Cancer Agents

The Hedgehog (Hh) signaling pathway is conserved in animals as diverse as fruit flies and humans. This pathway is involved in embryological development, and activation of the pathway in adult tissues ...
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Vladimir Spiegelman, Neehar Bhatia | P07243US02

Technology

Insertion Sequence-free Bacteria

A bacteria lacking genomic and non-genomic IS elements is provided. The bacteria may be more stable and useful for the production of amino acids, polypeptides, nucleic acids and other products.
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Frederick Blattner, John Campbell, David Frisch, Guy Plunkett III, Gyorgy Posfai | P06424US

Technology

Competent Bacteria

The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation compete...
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Frederick Blattner, Gyorgy Posfai, Christopher Herring, Guy Plunkett III, Jeremy Glasner, Trevor M. Twose | P03080US

Technology

Insertion Sequence-free Bacteria

The present invention provides a bacterium having a genome that is genetically engineered to be smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a com...
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Frederick Blattner | P06344US

Technology

Prophage Element-Free Bacteria

The present invention provides a bacterium having a genome that is genetically engineered to be smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a com...
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Frederick Blattner, John Campbell, David Frisch, Guy Plunkett III, Gyorgy Posfai | P06424US02

Technology

Artificial Transcription Factors and Uses Thereof

Transcription factor expression can profoundly alter the transcriptional dynamics of a cell, even inducing the transition to a new cell fate. Four transcription factors – Oct4, Sox2, Klf4, and c-Myc...
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Aseem Ansari, Asuka Eguchi | P160383US02

Technology

Nuclease Inhibitors and Methods for Their Use

Biochemical research and biotechnology rely on nucleic acids; however, nucleic acids frequently encounter nucleases that can negatively affect experiments. Although nuclease inhibitors are often used ...
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Ronald Raines, Bryan Smith, David Lynn, Matthew Soellner | P05096US

Technology

New Protein Production Strategy for Plants

In animals, plants and other eukaryotic organisms, typically one protein is translated from each mRNA. Usually, translation can start only at one end of the mRNA strand. In contrast, several viruses ...
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Aurelie Rakotondrafara, Jincan Zhang | P140069US02

Technology

Designing Ubiquitin Oligomers

Ubiquitin (Ub) is a small protein composed of 76 amino acids and found throughout the cells of eukaryotic organisms. It folds into a compact globular structure, often as part of a complex of proteins....
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Eric Strieter, Ellen Valkevich, Robert Guenette | P120240US02

Technology

Bacterial Transcription Enhancers

Bacterial production of recombinant proteins is used commonly by researchers and commercial entities to manufacture a large variety of proteins.
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Richard Gourse, Shawn Estrem, Tamas Gaal, Wilma Ross | P99238US

Technology

Promoter-Trap Plasmid for Identifying Promoters

Promoters are genetic regulatory elements that drive gene expression in cells under certain conditions. One way to identify promoters is to use a promoter-trap vector, which is a plasmid containing a ...
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Jo Handelsman, Anne Katherine Dunn | P03159US

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