Wisconsin Alumni Research Foundation

Technology

New Protein Production Strategy for Plants

In animals, plants and other eukaryotic organisms, typically one protein is translated from each mRNA. Usually, translation can start only at one end of the mRNA strand. In contrast, several viruses ...
Learn More
Aurelie Rakotondrafara, Jincan Zhang | P140069US02

Technology

Protecting Groups for Boronic Acids

Boronic acids (i.e., compounds that have a single boron-carbon bond) are one of the most useful functional groups in organic chemistry and chemical biology. They have applications in polymer sciences,...
Learn More
Ronald Raines, Brett VanVeller, Matthew Aronoff | P130142US02

Technology

Phosphine Ligands Made Cheaper, Better

Enantiomers are pairs of compounds that have the same chemical formula but different spatial structures (like your left and right hand, they are non-superimposable mirror images of each other). This i...
Learn More
Jennifer Schomaker, Robert Grigg, Ryan Van Hoveln | P130268US02

Technology

Chemical Synthesis of Reagents for Peptide Coupling

The Staudinger ligation method for synthesizing peptides requires phosphinothiol reagents that are not commercially available. The current method for making phosphinothiols is complicated (involving f...
Learn More
Ronald Raines, Laura Kiessling, Bradley Nilsson, Matthew Soellner, Yi He, Ronald Hinklin | P02304US

Technology

Production of Packaged DNA Sequence

Human Papillomavirus (HPV), the causative agent of cervical cancer, is the most common sexually transmitted pathogen. However, the amount of infectious papillomavirus available for research is greatly...
Learn More
Paul Ahlquist, Paul Lambert, Dohun Pyeon | P05033US

Technology

Singlet Oxygen-Resistant Technologies

Rhodobacter sphaeroides is a photosynthetic bacterium that is a useful model system for photosynthesis. Singlet oxygen (1O2) is a toxic byproduct of photosynthesis and other biological pathways that c...
Learn More
Timothy Donohue, Jennifer Anthony, Kristin Warczak, Yann DuFour, Heather Green | P05368US

Technology

Membrane Cascade-Based Separation

Purification of biological components, including viruses, plasmids, proteins and small molecules, typically relies on chromatography for most of the separation steps. Membrane filtration cascades prov...
Learn More
Edwin Lightfoot | P04423US

Technology

Membrane Cascade-Based Separation

Purification and separation are the most expensive steps in manufacturing modern biologicals, which include soluble proteins, nucleic acids, viruses and small molecules.
Learn More
Edwin Lightfoot, Michael Cockrem | P06389US

WARF