Wisconsin Alumni Research Foundation

Technology

Increasing Red Blood Cell Production

Maintaining an adequate supply of oxygen to tissue is necessary for survival. The oxygen-carrying capacity of blood is governed by the concentration of red blood cells (erythrocytes). It is critical t...
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Emery Bresnick, Yoon A Kang, Skye McIver | P130326US02

Technology

Common Variants of the Sodium Channel Alpha Subunits

The SCN5A gene encodes a human cardiac sodium (Na+) channel alpha subunit that carries the inward Na+ current in the heart. Three distinct polymorphic SCN5A clones, hH1, hH1a and hH1b, have been isola...
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Jonathan Makielski, Bin Ye, Michael Ackerman | P02284US

Technology

Production of Packaged DNA Sequence

Human Papillomavirus (HPV), the causative agent of cervical cancer, is the most common sexually transmitted pathogen. However, the amount of infectious papillomavirus available for research is greatly...
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Paul Ahlquist, Paul Lambert, Dohun Pyeon | P05033US

Technology

Assay to Detect Viral Uncoating

During or shortly after a retrovirus particle enters a host cell, the particle undergoes a process known as “uncoating,” where the viral genome is freed from the viral envelope and becomes...
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John Young, Shakti Narayan | P04156US

Technology

Protein Inhibitor of Ran Activity

Proteins and nucleic acids are actively transported in and out of the nucleus through nuclear pores. A small protein called Ran is the gatekeeper for large, complex pore structures.
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Ann Palmenberg, Frederick Porter, Christiane Wiese, Yury Bochkov | P06152US

Technology

Method to Screen for Novel Antibiotics

The antibiotic vancomycin targets the peptidoglycan-containing bacterial cell wall. Inducible resistance to vancomycin and other glycopeptide antibiotics is becoming a serious health problem, necessit...
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Bernard Weisblum, Robert Giannattasio, Arcady Grenader, Andrew Ulijasz, David Kovalic | P96061US

Technology

Stem Cell Marker for Breast Cancer

In patients who develop breast cancer, malignant tumors frequently begin in somatic mammary stem cells. In addition, breast tumors have a stem cell component that propagates the tumor, which may expla...
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Caroline Alexander, Bart Williams, Charlotta Lindvall, Nisha Badders | P07136US

Technology

Receptor For Bacillus anthracis Toxin

Infection with Bacillus anthracis, the spore-forming causative agent of anthrax, can result in either a generally benign, self-limiting cutaneous disease or a more serious and often fatal systemic dis...
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John Young, Kenneth Bradley, R. John Collier, Jeremy Mogridge | P00305US

Technology

Vaccine Candidates Against Johne's Disease

Johne’s disease is a contagious, chronic and usually fatal wasting disease that primarily affects the small intestine of ruminants. It is a worldwide problem with no known treatment and infects ...
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Adel Talaat | P05446US

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