Wisconsin Alumni Research Foundation

Technology

Wis.L Master Cell Bank for Vaccine Development

FDA-qualified cell lines must be used for virus production for human vaccines. There are relatively few of these lines available and several (WI-38, MRC-5) used for virus production are becoming senes...
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James Gern | P160170US01

Technology

Influenza Variant Grows Well in CHO Cells

Vaccines against influenza and other viruses can be grown in Chinese Hamster Ovary (CHO) cells. Problematically, an influenza virus that is made by combining H1N1 and PR8 strains, and that is recommen...
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Yoshihiro Kawaoka, Makoto Ozawa | P100246US02

Technology

Neuraminidase-Deficient Live Influenza Vaccine

Influenza infects up to 20 percent of the world’s population every year, causing 500,000 deaths and costing tens of billions of dollars in medical expenses. Influenza A virus, which causes pandemics...
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Yoshihiro Kawaoka, Masato Hatta | P07044US

Technology

Vaccine for Fungal Infections

There are no commercial vaccines against fungi. Infections like aspergillosis and Valley Fever can be life-threatening, particularly in immune-compromised patients. These patients also are more vulner...
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Bruce Klein, Theodore Brandhorst, Thomas Sullivan, Marcel Wuethrich | P130116US02

Technology

Safer Ebola Virus and Vaccines

Ebola is the deadliest virus on earth. It has caused death in 90 percent of cases during some outbreaks, afflicting human and great ape populations in tropical Africa. The virus is highly contagious i...
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Yoshihiro Kawaoka, Peter Halfmann, Jin Hyun Kim | P07377US02

Technology

Safer Influenza Vaccine from Replication-Knock Out Virus

Influenza viruses instigate annual global epidemics. The first influenza pandemic in 40 years occurred during the 2009-2010 season, when a novel H1N1 strain emerged and spread worldwide. The United St...
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Yoshihiro Kawaoka, Gabriele Neumann, Makoto Ozawa | P110003US02

Technology

Plasmids Encoding Avian Influenza Genes

Avian influenza causes significant economic losses for poultry producers worldwide and can be transmitted to humans and other mammals. The surface glycoproteins hemagglutinin (HA) and neuraminidase (N...
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Yoshihiro Kawaoka | P06123US

Technology

High Titer Recombinant Influenza Viruses for Vaccines

Influenza is caused by the eight-segmented influenza virus. Vaccines can be used to prevent influenza, but traditional methods for producing influenza vaccine are slow and cumbersome. To generate re...
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Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami | P06370US

Technology

Nanoparticles That Target Dendritic Cells

Dendritic cells play an important role in the process of initiating immune response. They are present in small quantities in tissues, such as skin and lung, that are in contact with the external envir...
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Ferencz Denes, Zsuzsanna Fabry, Matyas Sandor | P07026US

WARF