Wisconsin Alumni Research Foundation

Technology

2-methylene-19-nor Vitamin D2 Compounds

2-Methylene-19-nor-24(S) and 24(R) derivatives of 1α,25-dihydroxyvitamin D2 are disclosed. These compounds are characterized by minimal bone calcium mobilization activity and relatively high intestin...
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Hector DeLuca, Sumithra Gowlugari, Rafal Sicinski | P02026US

Technology

19-nor-vitamin D Analogs With 1,2-dihydrofuran Ring

19-nor-vitamin D analogs having an additional dihydrofuran ring connecting the 1α-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds ex...
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Hector DeLuca, Katarzyna Sokolowska, Rafal Sicinski, Lori Plum, Margaret Clagett-Dame, Agnieszka Glebocka | P08399US

Technology

2-methylene-20(21)-dehydro-19-nor-vitamin D Analogs

This invention discloses 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-20(21)-dehydro-19-nor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This comp...
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Hector DeLuca, Bulli Padmaja Tadi, Lori Plum, Margaret Clagett-Dame | P08364US

Technology

2-methylene-(20s,25s)-19,26-dinor-vitamin D Analogs

This invention discloses 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This comp...
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Hector DeLuca, Lori Plum, Margaret Clagett-Dame, Grazia Chiellini, Pawel Grzywacz | P08089US

Technology

2-methylene-(20s,25r)-19,26-dinor-vitamin D Analogs

This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This comp...
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Hector DeLuca, Lori Plum, Margaret Clagett-Dame, Grazia Chiellini, Pawel Grzywacz | P08090US

Technology

2-methylene-20-methyl-19,24,25,26,27-pentanor-vitamin D Analogs

This invention discloses 2-methylene-20-methyl-19,24,25,26,27-pentanor-vitamin D analogs, and specifically 2-methylene-20-methyl-1α-hydroxy-19,24,25,26,27-pentanor-vitamin D3, and pharmaceutical uses...
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Hector DeLuca, Lori Plum, Agnieszka Glebocka, Margaret Clagett-Dame, Rafal Sicinski | P08106US

Technology

2-methylene-(20s,25s)-19,27-dinor-(22e)-vitamin D Analogs

This invention discloses 2-methylene-(20S,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefo...
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Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Grazia Chiellini, Pawel Grzywacz | P07107US

Technology

19,26,27-trinor-1alpha,25-dihydroxyvitamin D3 Compounds

This invention relates to vitamin D compounds, and more particularly to 19,26,27-trinor-1α,25-dihydroxyvitamin D3 compounds such as 2α-methyl-19,26,27-trinor-(20S)-1α,25-dihydroxyvitamin D3 (“P...
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Hector DeLuca, Lori Plum, Pawel Grzywacz, Margaret Clagett-Dame | P05370US

Technology

17,20(z)-dehydro Vitamin D Analogs And Their Uses

This invention discloses 17,20(Z)-dehydro vitamin D analogs, and specifically 17(Z)-1α,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibi...
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Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Bulli Padmaja Tadi | P06097US

Technology

17,20(e)-dehydro Vitamin D Analogs And Their Uses

This invention discloses 17,20(E)-dehydro vitamin D analogs, and specifically 17(E)-1α,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibi...
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Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Bulli Padmaja Tadi | P06117US

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