HIV infection, AIDS and AIDS-related complex (ARC) remain serious and ongoing diseases compromising the human immune system. Protease inhibitors, which interfere with the replication cycle of HIV, are...
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The utility of many biologic drugs is limited by inefficient cellular delivery. There is a particular need for methods and reagents that facilitate delivery of peptides and proteins into the interior ...
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Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Proteins contain carboxyl groups. These charged groups make it difficult for any protein to enter a human (or other eukaryotic) cell. Modifying proteins to enter cells could revolutionize medicine, e....
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Boronic acids (i.e., compounds that have a single boron-carbon bond) are one of the most useful functional groups in organic chemistry and chemical biology. They have applications in polymer sciences,...
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The present disclosure provides compositions, methods and kits for the treatment of cancer. Particularly, the present disclosure provides synergistic compositions comprising at least one cytotoxic rib...
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Novel synthetic human scale collagen triple helices assemblies are disclosed. Methods of making self-assembling collagen mimetic peptides that self-assemble into human scale collagen are also disclose...
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Chemoselective transformations are of key importance in modern chemical biology. Protein esterification can, for example, be employed for labeling, enhanced cellular uptake and other useful protein mo...
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The green fluorescent protein (GFP) from the jellyfish Aequorea victoria is an extremely useful tool in biochemistry, molecular biology and diagnostics. This protein has been used to study gene expres...
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Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Biochemical research and biotechnology rely on nucleic acids; however, nucleic acids frequently encounter nucleases that can negatively affect experiments. Although nuclease inhibitors are often used ...
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Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Fluorescent molecules are essential tools for many scientific applications, including basic research, drug development, and disease diagnosis.
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Collagen, the most abundant protein in vertebrates, serves as the fundamental structural protein for vertebrate tissues. Collagen is a fibrous protein consisting of three polypeptide chains that fold ...
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Molecules that contain two functional groups of distinct reactivity can be used to link two biomolecules or to immobilize a biomolecule on a surface, such as a protein microarray. These bifunctional m...
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Disclosed herein are circular zymogens of RNase 1 that have a proteolytic cleavage site and are activated by a specific protease. These circular zymogens are useful for treatment of disorders that are...
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Collagen, the most abundant protein in vertebrates, provides structure for tissues and plays a key role in wound healing. In connective tissue, individual collagen molecules are wound together in tigh...
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The ability to deliver proteins into cells has many therapeutic and research applications. However, peptide drugs and therapeutic proteins are notoriously difficult to administer, in part because of t...
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Collagen is the most abundant protein in vertebrates. It serves as the fundamental structural protein for vertebrate tissues and is critically important in wound healing. Many diseases, including arth...
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Cellulosic biomass has tremendous potential as a renewable resource for the production of fuels and chemicals.  It is especially promising because it is inexpensive and readily available from cro...
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UW–Madison researchers previously developed a method of using traceless Staudinger ligation to chemically synthesize proteins (see WARF reference number P00315US).  This method is based on ...
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Diazo compounds, which have the general formula R2C=N2, are versatile intermediates in organic synthesis.  They participate in a variety of thermal, photochemical and metal-catalyzed reactions. M...
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The utility of many biologic drugs is limited by inefficient delivery into cells. Strategies to overcome this limitation have included enhancing the attraction between positively charged drug agents a...
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Disulfide bonds between cysteine residues are the most common crosslinking agents in proteins. Reducing these bonds is an ordinary procedure in biochemistry and biotechnology. The most commonly used r...
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Fossil fuel resources supply almost 90 percent of the world’s energy and the vast majority of its organic chemicals. This dependency is insupportable in light of rising emissions, demand and diminis...
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