WT-7695 has best-in-class properties for CA9 cancers
- BIC profile translated to greater in vivo tumor uptake, retention and efficacy
- 55 %IA/g delivered to tumor at 24 hours and 18 %IA/g retained at 7 days
- [177Lu]Lu-WT-7695 is 8-20x more efficacious in vivo than published data from competitor molecules
- IND-enabling studies begin early 2025
Study in ccRCC mouse model (SK-RC-52)
| SPR CA9 KD (nM)/off-rate (min) | Selectivity (X-fold) |
%IA/g @ 18.3 MBq 177Lu | % Survival @ 120 days | |||
| Human | Mouse | Monkey | CA4/12/14 | 24h | 7d | 1.0-3 mCi |
| 0.03/490 | 0.02/440 | 0.02/345 | 360/241/125 | 55% | 18% | 100% |
