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Novel Therapeutic Approaches to Target Movement Disorders: Discovery to Clinic – Craig Lindsley
Novel Therapeutic Approaches to Target Movement Disorders: Discovery to Clinic – Craig Lindsley
This lecture will discuss the basic pharmacology of Parkinson’s disease and dystonia, target identification and validation with novel GPCR ligands. Specifically, Craig Lindsley will discuss the development of mGlu4 PAMs as a pharmacological mimetic of deep bran stimulation and the optimization of a clinical candidate that is now in Phase I MAD studies. He will