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227 Results for 'Analytical Instrumentation, Methods & Materials'
PAGE 6 OF 10
Technology
Dielectric Sensor for Stress and Strain Detection
Load bearing structures experience stresses and/or strains that deform the material from which they are made. Regardless of a building component’s size, exposure to or tolerance for stress and s...
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Yuri Shkel, Ho Young Lee, Yiyan Peng | P08252US
Technology
Identifying Related Peak Sets to Boost Mass Spectrometry Throughput
Tandem mass spectrometry (MS/MS) is a technique capable of identifying large numbers of proteins in complex biological samples. In the process, peptides are ionized and an initial survey scan (i.e., a...
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Joshua Coon, Michael Westphall, Derek Bailey | P120336US01
Technology
More Flexible Microlens Assembly
‘Variable-focus’ lenses are lenses that have adjustable focal lengths. Liquid-based, miniaturized lenses of this type are useful in photonics, display systems and biomedical tools. However...
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Hongrui Jiang, Chenhui Li | P120362US01
Technology
Device Uses Air Gap for Easier Fraction Isolation
Isolating analytes from complex biological samples is one of the most crucial steps in many areas of biological research and clinical diagnostics. Paramagnetic particles (PMPs) or beads are important ...
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David Beebe, Scott Berry | P130107US01
Technology
Simplified Anisotropic Graphene Conductor Emits Terahertz Radiation
Terahertz (THz) electromagnetic radiation penetrates cloth, paper and partially into the skin without the damaging effects of X-rays. Portable electronic devices capable of generating this radiation w...
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Max Lagally, Francesca Cavallo, Richard Rojas-Delgado | P130002US01
Technology
Electrodes with Low-Cost Replaceable Tips
Electrodes routinely are used in electrochemical sensing, fuel cells, batteries and numerous other applications. Critically, the surface of an electrode must be clean before sensing elements can be at...
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Sundaram Gunasekaran, Jiang Yang | P120016US02
Technology
Ultra-Efficient Continuous Monitoring of Sensors
Tracking emissions, sensing earthquakes and monitoring patient brain waves are just a few of the applications that rely on changing, real-world information. In typical systems, sensors pass on raw dat...
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Mikko Lipasti, Atif Hashmi, Andrew Nere, Giulio Tononi | P130049US01
Technology
Optical System for Correction of Tissue-Induced Aberration
Confocal microscopy is used to view biological tissue through intervening tissues or structures. Multiphoton confocal microscopy uses a focused beam of photons to provide high-resolution images of tis...
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Andrew Sheinis | P07259US
Technology
Ultrasonic Welding with Real-Time Quality Control
In ultrasonic welding, work pieces are clamped between a horn and anvil and then joined using high-frequency vibration energy. Friction and heat between the surfaces causes them to soften and meld tog...
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Xiaochun Li, Hongseok Choi, Hang Li, Wayne Cai, Jeff Abell, Jingzhou Zhao | P120081US01
Technology
Cost-Effective Isobaric Tandem Mass Tags for High Throughput Quantitative Proteomics and Peptidomics
Mass spectrometry (MS) is a vital tool for identifying and tallying the different proteins, peptides and other molecules in a sample. To determine relative abundance, reagent tags are used to label th...
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Lingjun Li, Feng Xiang, Tyler Greer, Dustin Frost, Zhidan Liang | P110257US02
Technology
Low-Waste and Contamination Device for Isolating Cells from a Biological Sample
For diagnosis and research it often is necessary to isolate a subset of cells from a sample that contains bodily fluids, contaminants, tissue and other types of cells. For example, determining a pati...
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David Beebe, Scott Berry, David Guckenberger, Ben Casavant | P120222US01
Technology
More Efficient and Reliable High Power Quantum Cascade Lasers
Quantum cascade lasers (QCLs) are made of layered semiconductor materials and are suited for a variety of applications, ranging from environmental monitoring to explosives detection and missile-avoida...
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Dan Botez, Jaecheol Shin | P120315US01
Technology
Smoother Waveguides for More Efficient Nonlinear Frequency Conversion
For many applications – from remote sensing to laser displays – it is necessary to convert the frequency of light via nonlinear interaction in semiconductor materials. Waveguide devices accomplish...
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Dan Botez, Thomas Kuech, Luke Mawst, Steven Ruder | P120326US01
Technology
Snap-On Microfluidic Lid for Handheld Diagnostics and Chemical Tests
Investigation of cells, biochemicals and other samples by microfluidic devices stands to aid a full spectrum of research, from global HIV initiatives to the development of new drugs. Such devices prov...
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David Beebe, Erwin Berthier, Eric Sackmann, Peter Cavnar, David Guckenberger | P110044US01
Technology
Handheld Cell Maintenance and Assay Device with Functional Microfluidic Lid
The cellular-scale engineering that undergirds microfluidic systems has provided researchers with efficient tools for the analysis and manipulation of cells in vitro minisculo. Methods and devices ref...
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David Beebe, David Guckenberger, Peter Cavnar, Erwin Berthier | P110339US01
Technology
Fast, Flexible Platform for Handheld Microfluidic Cell Assays
Identifying pathways involved in human diseases is the first step in the discovery of targets for therapy and diagnostics. Cell-based assays conducted in vitro are powerful tools in this process. Reco...
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Erwin Berthier, David Guckenberger, David Beebe, Peter Cavnar | P120238US01
Technology
Monolithic Fiber Optic Sensor Assembly for High-Temperature or Corrosive Environments
Remote spectrographic measurements can be made using a fiber optic guide attached to a “U-bench,” an optical component that supports a light emitter opposite from a light collector or a mirror acr...
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Scott Sanders | P120024US01
Technology
Steering and Tuning Lasers Formed by Nanoscale Microtubes
Microtubes are minute structures of layered metal that have shown wide promise in many fields. Beyond wireless sensing and drug delivery, they are poised to improve optical technologies. Fiber optic ...
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Robert Blick, Luke Mawst | P08124US01
Technology
Gas-Phase Purification of Peptides Reaps Accuracy in Mass Spectrometry Quantitation
Maturing protein analysis technologies continue to elucidate life’s chemical architecture with a precision even recently unimaginable. Mass spectrometry (MS), which ionizes and fragments proteins fo...
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Joshua Coon, Michael Westphall | P110234US02
Technology
Robust Substrates Expand the Utility of Surface Plasmon Resonance Imaging for Analysis of Biomolecular Interactions
Surface plasmon resonance (SPR) imaging has demonstrated its ability to monitor interactions between biological moieties in real time without the aid of chemical labels such as fluorophores and radioi...
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Lloyd Smith, Matthew Lockett, Michael Shortreed, Robert Corn, Stephen Weibel, Bin Sun, Robert Hamers | P07133US
Technology
Achieving Precision Laminar Flow for Biological Microfluidics
Despite the growing interest in the natural interactions between different cellular compartments— and the increasing need to model these phenomena in vitro—no method currently in practice in biolo...
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David Beebe, Jay Warrick, Erwin Berthier | P100313US01
Technology
Short-Pulsed Alkali Magnetometer for Precision in Ambient Fields
Detection of magnetic fluctuations is vital to endeavors from space navigation to oil exploration. UW–Madison researchers previously developed a method that utilizes sensitive alkali atoms—polariz...
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Thad Walker, Brian Lancor, Robert Wyllie | P110354US01
Technology
Increasing Peptide and Protein Identifications with Prioritized Mass Spectrometry
As resources shift from genome sequencing to understanding and characterizing expressed genes and protein function, reliable and rapid tools for the analysis of protein composition are increasingly vi...
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Joshua Coon, Douglas Phanstiel, Graeme McAlister | P110191US01
Technology
Microfluidic Device for Drug Delivery
Oral ingestion of pharmaceuticals is considered the safest, most convenient and most economical method of administering drugs. However, many pharmaceuticals cannot be delivered orally because they are...
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David Beebe, Michael MacDonald, David Eddington, Glennys Mensing | P04240US
Technology
Precision Magnetometer for More Accurate Magnetic Field Readings
A magnetometer is a scientific instrument used to measure the strength and/or direction of magnetic fields. It has applications in areas such as navigation systems, geophysics and drilling/mining expl...
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Thad Walker, Brian Lancor, Robert Wyllie | P110198US01