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227 Results for 'Analytical Instrumentation, Methods & Materials'
PAGE 5 OF 10
Technology
Research Tool for Protein Conformation Analysis
The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Michael Sussman, J. Leon Shohet, Faraz Choudhury, Joshua Blatz, Benjamin Minkoff, Daniel Benjamin | P160180US02
Technology
Improved Sensor Enables Sensitive Detection of Large Molecules in Mass Spectrometry
Mass spectrometry is a highly selective and quantitative technique that is widely used to determine the chemical composition of a sample. Applications of this analytical tool include measuring isotope...
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Robert Blick, Michael Westphall, Lloyd Smith | P05110US
Technology
Single-Crystal Halide Perovskite Nanowires with Superior Performance
Semiconductor nanowire lasers are promising building blocks in state-of-the-art photonic and optoelectronic devices due to their advantageous properties – including ultracompact size, efficient wave...
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Song Jin, Yongping Fu, Fei Meng | P160053US01
Technology
Optimized Nanoresonator Design Signals Breakthroughs in Spectrometry and Device Efficiency
An optical resonator is an arrangement of optical components that allows a beam of light to circulate in a closed path. Nanoresonators are a type of optical resonator that can effectively concentrate ...
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Zongfu Yu, Ming Zhou | P160052US01
Technology
Tunable, Silicon-Based Fresnel Lenses
A Fresnel lens or ‘zone plate’ is a type of compact lens made of concentric rings that alternate between opaque and transparent materials. The design is lighter and smaller than conventional lense...
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Hongrui Jiang, Yen-Sheng Lu, Hewei Liu | P140128US01
Technology
Multiphoton Flow Cytometer for High Throughput Analysis of Multicellular Aggregates Like Pancreatic Islets
Regenerative medicine requires a practical, high throughput method of assessing the cellular components of multicellular entities before transplantation. Such a method would have many clinical and res...
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Brenda Ogle, Luis Fernandez, Kevin Eliceiri, Matthew Hanson | P07386US
Technology
All-Glass Optical Microresonator for Single Molecule Spectroscopy and More
Label-free sensing methods could enable detection and characterization of chemical species at the single molecule level without the aid of probes or modifications to the target of interest. Such capab...
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Randall Goldsmith, Kassandra Knapper, Kevin Heylman | P150382US01
Technology
New Gradient-Based Cell Labeling Method Maintains Location Information During Downstream Analysis
Cellular ecology is a major factor in processes like cell signaling and transport as well as in the development and progression of systemic diseases like cancer. In situ, in vitro studies are becoming...
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David Beebe, Erwin Berthier, Mary Regier | P150171US01
Technology
Streamlined Design for Transferring Analytes
Polymerase chain reaction (PCR) is used to generate copies of a particular DNA sequence. The technique is common and indispensable in many research applications. Unfortunately, methods for isolating/p...
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David Beebe, Ben Casavant, David Guckenberger, Scott Berry | P130361US01
Technology
Temperature Gradient Handling System for Surface Plasmon Resonance (SPR) Measurements
Measuring biomolecular interactions is a critical component in studies focused on nucleic acid and protein binding. For instance, in the pharmaceutical industry, it is crucial in the drug discovery an...
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Aric Opdahl | T150042US03
Technology
Multi-Wavelength Mode-Locked Laser
Many laser applications require multiple, simultaneous laser beams, each with a specific wavelength. But using multiple lasers and associated optical components increases the cost and size of the syst...
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Scott Sanders | P07171US
Technology
Circulating Tumor Cell Assay Using Simple Blood Draw
Circulating tumor cells (CTCs) are cells shed from tumor deposits that flow into the bloodstream. They are detected at a frequency of about one CTC per one billion surrounding blood cells. The great h...
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David Beebe, Joshua Lang, Ben Casavant, Scott Berry, Lindsay Strotman | P130171US01
Technology
New Mass Spectrometry Detector Uses Optically Active Membrane
Mass spectrometers are analytical instruments that can precisely measure the mass of molecules to determine their composition and identity. Generally, the molecules are ionized and then accelerated by...
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Robert Blick, Jonathan Rodriguez, Hyunseok Kim, Zlatan Aksamija, Wolfgang Hansen, Christian Heyn | P140174US01
Technology
Multiplexed Mass Spectrometry Quantification with Neutron-Encoded Mass Tags
In the past decade, cataloguing the thousands of proteins present in a cell using mass spectrometry (MS) has matured into a procedure both deeply vital and straightforward. Yet discovering how such mo...
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Joshua Coon, Alexander Hebert | P130032US01
Technology
Microcavity Method for Single Molecule Spectroscopy
Single molecule spectroscopy and microscopy – a popular tool for biological, biophysical and chemical characterization – generally requires the use of fluorescent molecules. Researchers at UW–M...
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Randall Goldsmith, Kevin Heylman | P140153US03
Technology
Multidimensional Imaging with Improved Contrast
Studying molecular properties in complex chemical and biological samples, including live cells, requires sufficient spatial resolution and contrast between different substructures. To achieve enhanced...
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John Wright, Erin Boyle | P140021US02
Technology
More Efficient Semiconductor Lasers
Quantum cascade lasers (QCLs) are semiconductor lasers that provide light in the mid- and far-infrared wavelength ranges. They are designed so that the generated light is transverse-magnetic (TM) pola...
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Luke Mawst, Dan Botez, Thomas Earles, Jeremy Kirch, Christopher Sigler | P140047US01
Technology
Microscope Probe Having an Ultra-Tall Tip
Atomically sharp micro-fabricated tips are used in atomic force microscopy (AFM) for scanning near-field microwave microscopy (SNMM) to create an image of the tiny topography on or under a surface. Th...
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Daniel van der Weide, Yaqiang Wang | P06244US
Technology
Bioreversible Protein Esterification
Proteins contain carboxyl groups. These charged groups make it difficult for any protein to enter a human (or other eukaryotic) cell. Modifying proteins to enter cells could revolutionize medicine, e....
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Ronald Raines, Nicholas McGrath | P130148US02
Technology
Strain-Tunable Light Emitting Diodes Using Germanium
Germanium (Ge), a group-IV semiconductor material, is crucial to many established and potential technologies. In optoelectronics, Ge has been used as a photodetector material for on-chip data distribu...
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Max Lagally, Jose Sanchez Perez | P140041US01
Technology
Microwell Moat Prevents Spillover
The ability to study single cells has become indispensable, helping researchers identify characteristics and behaviors otherwise hidden using population averages. By obtaining multiple measures per ce...
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Jay Warrick, John Yin, Stephen Lindsay | P120353US01
Technology
Tuning Optical Microcavities
A whispering gallery mode (WGM) is a type of electromagnetic wave that travels around a concave surface. Such waves can propagate at the edge of a very small structure called an optical microcavity. W...
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Randall Goldsmith, Kevin Heylman | P140153US01
Technology
Non-Intrusive Monitoring of Combustion Chambers
Exhaust emission and fuel economy standards have put increased pressure on the auto industry to improve the efficiency of internal combustion engines. While higher standards help protect the environme...
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Michael Andrie | P08225US
Technology
Compact Spectrometer
Spectrometers are optical instruments used to measure light. They work by detecting spectral lines and measuring their wavelength or intensity. Spectrometers have many applications, including telecomm...
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Zongfu Yu | P140145US01
Technology
Faster Gas-Phase Protein Sequencing
Determining the amino acid sequence of any given protein or polypeptide is a formidable task. The first major technology to emerge for this purpose was the Edman degradation method, which sequences a ...
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Lloyd Smith, Michael Westphall, Xiaoyu Chen, Brian Frey | P04178US