The ability to unambiguously mark a cell’s genotype is essential for studies in which genetically distinct cell populations must be distinguished from one another in vivo.
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The ability to unambiguously mark a cell’s genotype is essential for studies in which genetically distinct cell populations must be distinguished from one another in vivo.
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Titin is a very large cardiac protein that determines the resting tension of the heart in rats. Isoforms of titin are generated by alternative splicing of a single titin gene. Titin in embryonic rat h...
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The liver detoxifies many of the drugs and toxins in blood, which poses a problem in drug development and testing because drugs are rapidly cleared from the system. In the mammalian fetus, the liver i...
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Humans with mutations in the Adenomatous Polyposis Coli (APC) gene develop hundreds or even thousands of adenomas in the colon, which often lead to colorectal cancer. Mouse models of human intestinal ...
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Few treatments for neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, have been discovered.  In many cases, the molecular basis for neurodegeneration rem...
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The antibiotic vancomycin targets the peptidoglycan-containing bacterial cell wall. Inducible resistance to vancomycin and other glycopeptide antibiotics is becoming a serious health problem, necessit...
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Effective and non-destructive treatments are needed for diabetic retinopathy, a major cause of blindness in the United States. Thrombospondin1 (TSP1), a matricellular protein that inhibits angiogenesi...
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When using live vertebrate animals, principal investigators for any activity supported by a Public Health Service (PHS) agency, such as the FDA, NIH or CDC, must comply with the PHS policy on Humane C...
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Glaucoma is a group of diseases that can result in vision loss and blindness. According to the World Health Organization, glaucoma is the second leading cause of blindness worldwide. Glaucoma causes...
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Neutrophils, the most common type of white blood cells, undergo a process called chemotaxis that helps them travel toward sites of inflammation. Because inflammation plays a central role in the pathog...
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Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Inhibitors of SCD may be useful as therapeutic agents for the treatment of diseases such a...
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