WARF TECHNOLOGIES

Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. SCDs may influence the development of diseases such as obesity, atherosclerosis and diabetes.

A UW–Madison researcher has developed several mouse strains and cells useful in the study of SCDs.  To understand the tissue-specific role of SCD1 and other SCD isoforms in disorders such as obesity, diabetes, cancer, inflammation, atherosclerosis and metabolism, the researcher generated mice with tissue-specific knockouts of SCDs.  He also developed transgenic mice in which SCDs can be overexpressed in specific tissues.

• Studying SCDs and their tissue-specific roles 

• Provides new tools for investigating the roles of SCD isoforms in various tissues

Related Technologies

• WARF reference number P06455US describes a transgenic mouse model for the human SCD5 isoform.
• WARF reference number P05362US describes useful tools for identifying SCD inhibitors.

Tech Fields

• Drug Discovery & Development : Other drug discovery & development
• Research Tools : Animal & disease models
• Research Tools : Cell lines