Wisconsin Alumni Research Foundation

Technology

Primatized Mouse

The present invention is a novel, primatized mouse model for studying the immune system of nonhuman primates in a relatively low-cost mouse. The UW-Madison inventor used a different source of immune c...
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Matthew Brown | P210237US02

Technology

Knockout of GFAP In the Mouse (Model tm1Mes)

UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
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Albee Messing, Maureen McCall | P220164US01

Technology

Mouse Models for Protein Granule Diseases

Overload of protein granules in cells induces many forms of diseases, and is especially found in neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis as well as ver...
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Wei Guo | P210193US01

Technology

Animal Model of Brittle Bone Disease

Osteogenesis imperfecta (OI) or brittle bone disease is an incurable genetic disorder that causes fragile bones and a lifetime of breaks and fractures. Recently, mutations in the gene for bone morphog...
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Daniel Greenspan, Se-Jin Lee | P160036US01

Technology

Wisconsin Miniature SwineTM for Biomedical Research

Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
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Jess Reed, Christian Krueger, Dhanansayan Shanmuganayagam, Thomas Crenshaw, Jamie Reichert, Joan Parrish | P130271US01

Technology

Wisconsin Miniature SwineTM for Cardiovascular Research

Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
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Jess Reed, Christian Krueger, Dhanansayan Shanmuganayagam, Thomas Crenshaw, Jamie Reichert, Joan Parrish | P140228US01

Technology

Mouse Model for Mania

Presently, there are no good rodent models for mania, which is a critical component of bipolar disorder. The most commonly used approach is to inject normal mice with amphetamines to produce hyperacti...
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Stephen Gammie | P100188US01

Technology

Feline Model of Glaucoma

Glaucoma, the second leading cause of blindness in the United States, is an eye disease that results in optic nerve damage and loss of vision. However, few large-eyed models of spontaneous glaucoma ex...
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Gillian McLellan, Matthew Ellinwood, Markus Kuehn | P110032US01

Technology

A Transgenic Mouse Model for Human Liver Disease

Many of those currently on waiting lists for liver transplants are victims of liver failure associated with hepatocyte toxicity. This toxicity can be caused by alcohol abuse, or by prescription or non...
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Eric Sandgren, Kristin Braun, Teresa Weglarz, Jay Degen | P01325US

Technology

Laboratory Rat Procedural Techniques Training DVD and Manual

When using live vertebrate animals, principal investigators for any activity supported by a Public Health Service (PHS) agency, such as the FDA, NIH or CDC, must comply with the PHS policy on Humane C...
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John Bogdanske, Beth Schiffman, Scott Hubbard-Van Stelle, Margaret Riley | P09138US

WARF