UW-Madison researchers have developed methods for deriving right ventricle-like cardiomyocytes from second heart field (SHF) cardiac progenitors. The addition of insulin or the inhibition of endogenou...
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UW-Madison researchers have developed methods for generating arterial hemogenic endothelium and hematopoietic progenitors using a 3D spheroid (75-150mM) “hanging drop” method, and they fou...
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UW-Madison researchers have discovered that inducing SOX18 expression in hPSCs during hematopoietic differentiation promotes specification and expansion of erythromyeloid progenitors, megakaryocytes a...
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UW-Madison researchers have developed a simple and versatile method to spatially pattern hPSC differentiations via localized adsorption of morphogens on substrates. Morphogens including BMP4, noggin, ...
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The inventors have developed a novel system for co-differentiation of hepatocytes and hematopoietic progenitors from human embryonic stem cells (ES cells) that mimics a late fetal liver undergoing hem...
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Provided herein are methods and compositions for inducing chemical senescence in neurons and methods of using chemically induced senescent neurons for modeling neurodegenerative disease and drug disco...
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The present invention provides methods of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. The methods involve inducing the expression of...
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Previous methods for culturing primate pluripotent stem cells have required either fibroblast feeder cells or a medium which was exposed to fibroblast feeder cells to maintain the stem cells in an und...
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Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells...
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Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells...
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Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS c...
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Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving iPS c...
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Vitronectin-derived cell culture substrates and methods of using the same for culturing pluripotent stem cells are presented.
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Methods are provided that exploit thermostable FGF-1 proteins for support of human pluripotent stem cell cultures. Also provided are compositions containing thermostable FGF-1 for culturing of human p...
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Thermostable FGF-2 proteins having enhanced ability to support human pluripotent stem cell cultures are provided. Also provided are methods and compositions utilizing thermostable FGF-2 proteins.
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Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into biomimetic neural tissues com...
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Described herein are methods, compositions, and kits for forming engineered in vitro biomimetic, three-dimensional, tubular organoid structures by directed differentiation of human pluripotent stem ce...
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Disclosed are compositions and methods for pluripotent stem cell culture. Compositions include mineral coated microparticles having a core and a mineral coating, wherein the mineral coating includes f...
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Throughout a person’s lifetime the heart undergoes slow cellular turnover. This steady regeneration is critical to maintaining healthy cardiac function from birth to old age. The heart’s a...
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A stem cell’s microenvironment plays a key role in regulating its behavior (e.g., adhesion, migration, proliferation and differentiation). A variety of templates have been used to study stem cell be...
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To leverage the phenomenal potential of pluripotent cells, either embryonic or induced, it is critical to develop standardized culture conditions free of animal products or serum, which tend to vary f...
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For researchers, cloning human embryonic stem (ES) cells is challenging because it requires growing new colonies from a single cell. One difficulty is very low cloning efficiency – less than 0.1 pe...
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Embryonic stem cells form aggregates, called embryoid bodies (EBs), before differentiating into distinct types of cells. Clumps of stem cells can vary widely in size, shape and volume, resulting in no...
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Human embryonic stem (hES) cells are capable of self-renewal, as long as they remain undifferentiated. Culture conditions, including the medium and substrate the cells are grown in, play an important ...
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Human embryonic stem (ES) cells are potentially capable of supplying cells and tissues for replacement of defective human tissue. However, procedures currently used to culture human ES cells involve t...
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