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54 Results for 'Detection'
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Technology
Electronically Activated Strained Alkynes
Jennifer Schomaker, Eileen Burke | P170043US03
Technology
Lesion Volume Measurements System
Randall Kimple, Junzhou Chen, Hunter Higby, Ryan Wisth, Kyuhyun Lee, Jeremy Rogers | P190262US02
Technology
Sensor For Cyanuric Acid Detection
Srivatsan Raman, Xiangyang Liu | P180322US02
Technology
A Ratiometric Biosensor To Measure Intracellular Nadh/Nad+ Redox
Srivatsan Raman, Yang Liu, Robert Landick | P190071US02
Technology
Methods And Systems For Isolating And Identifying Nucleic Acid From A Plurality Of Microorganisms And Viruses
Tony Goldberg, Samuel Sibley | P160266US02
Technology
Multicolor Reporter Cells for Detecting and Quantifying HIV-1
It is estimated that half of new HIV infections in the U.S. are from patients who know they are HIV-positive but underestimate their transmissibility. Identifying and monitoring the latent HIV reservo...
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Nathan Sherer, Jordan Becker | P160337US02
Technology
Platform for High-Throughput Analysis of Microbial Interactions
In nature, most microbes live in synergistic communities (microbiomes) as a way to thrive in various environments. For example, more than 100 trillion bacteria are estimated to live in the human gut a...
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Ophelia Venturelli, Philip Romero, Ryan Hsu, Jin Wen Tan | P190033US02
Technology
Designing Programmable Inducible Promoters for Biosensor Applications
Biosensors to detect small molecule ligands (e.g., metabolites) have applications in synthetic biology, medical diagnosis, environmental monitoring, bioremediation and bioenergy. Protein-based biosens...
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Srivatsan Raman, Aseem Ansari, Xiangyang Liu, Jose Rodriguez-Martinez | P170081US02
Technology
Improved Molecule Mass Detection Using Electron Field Emission from Kinetically Impacted Membranes
Mass spectrometry is a broadly applicable analysis tool for detecting and characterizing molecules and other chemical species, including complex mixtures of biomolecules such as peptides, proteins or ...
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Robert Blick, Lloyd Smith, Michael Westphall, Hua Qin | P09192US
Technology
Improved Sensor Enables Sensitive Detection of Large Molecules in Mass Spectrometry
Mass spectrometry is a highly selective and quantitative technique that is widely used to determine the chemical composition of a sample. Applications of this analytical tool include measuring isotope...
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Robert Blick, Michael Westphall, Lloyd Smith | P05110US
Technology
Zip-Lignin™ Assay: An Analysis and Validation Tool
To produce pulp from wood, harsh chemicals are applied during cooking and bleaching mainly because lignin is tough to break down. To make it easier to degrade, Wisconsin researchers discovered how che...
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John Ralph, Steven Karlen, Fachuang Lu, Dharshana Padmakshan | P150118US02
Technology
Bioluminescent Influenza Virions for High Throughput Screening
Assays currently used to detect neutralizing antibodies to influenza virus or measure virion binding to cells, antibodies or receptors require multiple steps. These steps are destructive, low sensitiv...
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Andrew Mehle | P160304US01
Technology
New Influenza B Virus Enables Real-Time Tracking of Disease Progression
Influenza infections in humans, from the common seasonal flu to the deadly pandemics of the 20th century, are caused chiefly by influenza A and influenza B viruses. Understanding the in vivo dynamics ...
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Andrew Mehle | P160032US01
Technology
Multiphoton Flow Cytometer for High Throughput Analysis of Multicellular Aggregates Like Pancreatic Islets
Regenerative medicine requires a practical, high throughput method of assessing the cellular components of multicellular entities before transplantation. Such a method would have many clinical and res...
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Brenda Ogle, Luis Fernandez, Kevin Eliceiri, Matthew Hanson | P07386US
Technology
Circulating Tumor Cell Assay Using Simple Blood Draw
Circulating tumor cells (CTCs) are cells shed from tumor deposits that flow into the bloodstream. They are detected at a frequency of about one CTC per one billion surrounding blood cells. The great h...
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David Beebe, Joshua Lang, Ben Casavant, Scott Berry, Lindsay Strotman | P130171US01
Technology
New Mass Spectrometry Detector Uses Optically Active Membrane
Mass spectrometers are analytical instruments that can precisely measure the mass of molecules to determine their composition and identity. Generally, the molecules are ionized and then accelerated by...
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Robert Blick, Jonathan Rodriguez, Hyunseok Kim, Zlatan Aksamija, Wolfgang Hansen, Christian Heyn | P140174US01
Technology
Multiplexed Mass Spectrometry Quantification with Neutron-Encoded Mass Tags
In the past decade, cataloguing the thousands of proteins present in a cell using mass spectrometry (MS) has matured into a procedure both deeply vital and straightforward. Yet discovering how such mo...
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Joshua Coon, Alexander Hebert | P130032US01
Technology
Influenza Reporter Virus Imaged In Vivo
Currently, it is not possible to visualize the in vivo dynamics of an influenza infection. All existing models rely on proxies to measure viral replication (e.g., viral concentration in nasal washes) ...
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Andrew Mehle | P130288US01
Technology
Low-Waste and Contamination Device for Isolating Cells from a Biological Sample
For diagnosis and research it often is necessary to isolate a subset of cells from a sample that contains bodily fluids, contaminants, tissue and other types of cells. For example, determining a pati...
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David Beebe, Scott Berry, David Guckenberger, Ben Casavant | P120222US01
Technology
Robust Substrates Expand the Utility of Surface Plasmon Resonance Imaging for Analysis of Biomolecular Interactions
Surface plasmon resonance (SPR) imaging has demonstrated its ability to monitor interactions between biological moieties in real time without the aid of chemical labels such as fluorophores and radioi...
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Lloyd Smith, Matthew Lockett, Michael Shortreed, Robert Corn, Stephen Weibel, Bin Sun, Robert Hamers | P07133US
Technology
Devices and Methods for Immobilizing Liquid Crystal Droplets onto a Chemically Functionalized Substrate Surface
Liquid crystal materials are promising candidates for many sensing and interfacial applications. Liquid crystals respond to and amplify small changes in temperature, electric or magnetic fields, shear...
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David Lynn, Maren Buck, Nicholas Abbott, Michael Kinsinger | P100260US02
Technology
Parallel Measurements by Fluorescence and Mass Spectrometry for Absolute Quantification of Proteins
Mass spectrometry (MS) has become the principal tool for routine identification of proteins and their post-translational modifications (PTMs). Quantification of the amounts of proteins and PTMs is req...
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Joshua Coon, Lloyd Smith, Ryan Hilger, Jason Russell, Daniel Ladror, Michael Shortreed, Mark Scalf | P100208US01
Technology
Microwave Cavity Detector for Highly Sensitive Mass Spectrometry Detection of Large Molecules
Mass spectrometers are analytic instruments that precisely measure the mass of molecules, and therefore may be used to determine composition and molecule identity based on mass data. Generally, the mo...
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Robert Blick, Jonghoo Park | P100106US01
Technology
Microtube Scaffold for Sensing and Stimulating Nerve Cell Connections
Studying how neurons and other cells work may require stimulating individual or small clusters of cells. The cells conventionally are stimulated through the use of fine electrodes inserted into or nea...
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Robert Blick, Justin Williams, Minrui Yu, Yu Huang | P100158US01
Technology
Nanoscale and Microscale Wireless Stimulating Probes Precisely Deliver Electrical Current to Cells
Studying how neurons and other cells work may require stimulating individual or small clusters of cells. The cells conventionally are stimulated through the use of fine electrodes inserted into ...
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Robert Blick, Max Lagally | P07076US