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28 Results for 'Diagnostics'
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Technology
THE MIDBODY AND MIDBODY REMNANT ARE ASSEMBLY SITES FOR RNA AND ACTIVE TRANSLATION
UW-Madison researchers have discovered that the midbody (MB) functions as an RNA-based organelle with active translation activity, which serves as a novel means of RNA-based intercellular communicatio...
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Ahna Skop, Sungjin Park, Smit Patel | P230134US02
Technology
A High Throughput Newborn Screening Assay For Angelman And Prader-Willi Syndromes
A UW researcher has developed a higher throughput method for detection of the methylation pattern of the alleles involved in Prader-Willi and Angelman disorders from dried blood spots. This method pro...
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Mei Baker | P230235US02
Technology
NOVEL AUTO-ANTIBODIES AND METHOD TO DETECT SJÖGREN’S DISEASE
A UW-Madison researcher has developed a new diagnostic assay for Sjogren's syndrome, based on her discovery of novel autoantibodies relevant to the disease process. Using whole peptidome array tec...
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Sara McCoy, Miriam Shelef, Michael Newton, Zihao Zheng | P220234WO01
Technology
IDENTIFYING DISEASE-CAUSING HUMAN DDX41 GENETIC VARIANTS
UW-Madison researchers have developed a genetic rescue assay that discriminates the activities of wild type DDX41 from those of human myeloid malignancy-associated germline and somatic DDX41 mutants. ...
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Emery Bresnick, Jeong-Ah Kim | P230033US02
Technology
An Optimized, More Efficient Method for Characterizing Microorganisms and Viruses Using Metagenomics
Metagenomics is the study of genetic material from environmental samples for detecting microbes, especially pathogens. It is increasingly used within clinical and industrial settings. While metagenomi...
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Tony Goldberg, Samuel Sibley | P160266US02
Technology
UNIVERSAL METHOD FOR PARASITE AND EUKARYOTIC ENDOSYMBIONT IDENTIFICATION
UW-Madison researchers have developed and validated a novel “parasitome” method to accurately characterize parasites in samples. Like published metabarcoding protocols, the new method consists of ...
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Tony Goldberg, Leah Owens | P220194WO01
Technology
High-Throughput Microfluidics Platform Enables Scalable Single-Cell Nucleic Acid Biomarker Detection
Detection of genetic aberrations using nucleic acids as biomarkers can be a powerful strategy for disease diagnosis and progression monitoring; however, the high heterogeneity of cells within a patien...
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Philip Romero, Leland Hyman | P180094US02
Technology
AN ACCURATE AND COMPREHENSIVE CARDIAC TROPONIN I ASSAY ENABLED BY NANOTECHNOLOGY AND PROTEOMICS
UW-Madison researchers have developed mass spectrometry (MS) compatible nanoparticles for the selective capture and enrichment of low abundance proteins. The surface of superparamagnetic nanoparticles...
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Ying Ge, Song Jin, Timothy-Neil Tiambeng, David Roberts | P190235US02
Technology
ANTI-GATA2 MONOCLONAL ANTIBODIES
UW-Madison researchers have developed three novel monoclonal antibodies that all have exceptional activity against human and mouse GATA2.
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Emery Bresnick, Daniel Matson | P220242US01
Technology
IDENTIFICATION OF SARS-COV-2 EPITOPES DISCRIMINATING COVID-19 INFECTION FROM CONTROL AND METHODS OF USE
UW – Madison researchers have determined that SARS-CoV-2 infection induces antibodies against both structural and non-structural proteins and they identified epitopes in the SARS-CoV-2 membrane prot...
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Irene Ong, David O'Connor, Miriam Shelef, Anna Heffron, David Baker, Maya Amjadi, Sean McIlwain, Saniya Khullar | P210048WO01
Technology
ONE-STEP SAMPLE EXTRACTION CASSETTE AND METHOD FOR POINT-OF-CARE MOLECULAR TESTING
The current gold standard method for COVID-19 testing is a multi-step protocol
25 involving RNA extraction using column-based or magnetic bead-based methods,
followed by RT-qPCR-based detection of the...
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Duane Juang, Terry Juang, David Beebe | P210247US01
Technology
Toilet, Testing and Monitoring Systems
Systems for monitoring metabolites may include a sample collection system and a urinalysis system of or for a toilet. The sample collection system may be automated to collect sample urine from a toi...
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Joshua Coon, Michael Westphall, Ian Miller, Lloyd Smith, Keaton Mertz | P200202WO01
Technology
Epigenetic Modification of Select Genes as Markers of Hypersomnolence
Differentially methylated positions associated with hypersomnolence, idiopathic hypersomnia, and long sleep time are provided herein along with biomarker panels thereof and methods of diagnosing and p...
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David Plante, Reid Alisch | P200207WO01
Technology
Microbial Glycans As A Target Of Human Intelectin
The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including ...
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Laura Kiessling, Darryl Wesener, Kittikhun Wangkanont | P150027US02
Technology
Bystander Immune Suppression As A Predictor For Response To A Vaccine
The present invention relates to antigen-specific immune regulatory response. Methods for detecting an antigen-specific immune regulatory response, methods for selecting candidate vaccine recipients, ...
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Douglas McNeel, William Burlingham | P100331US02
Technology
Using Liquid Crystal To Detect Endotoxin In The Presence Of One Or More Potential Masking Agents
Devices and methods for using changes in the configuration of micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide ...
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Nicholas Abbott, Abhijit Dan | P160072US02
Technology
Biomarkers For Early Diagnosis And Differentiation Of Mycobacterial Infection
Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.
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Adel Talaat, Chia-Wei Wu | P190048US02
Technology
Multicolor Reporter Cells for Detecting and Quantifying HIV-1
It is estimated that half of new HIV infections in the U.S. are from patients who know they are HIV-positive but underestimate their transmissibility. Identifying and monitoring the latent HIV reservo...
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Nathan Sherer, Jordan Becker | P160337US02
Technology
Enhanced Endotoxin Detection: New Advantages in Liquid Crystal Assays for Gram-Negative Pathogens
Gram-negative bacterial infections are an ongoing challenge to health care providers worldwide. Detection, treatment and control of such pathogens have gained increasing importance in the context of a...
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Nicholas Abbott, Abhijit Dan | P160072WO01
Technology
Field Test for Mycobacterial Infections
Mycobacterial infections cause major health problems for people and animals, including human tuberculosis, bovine tuberculosis and Johne’s disease. Johne’s disease (or paratuberculosis) afflicts 9...
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Adel Talaat | P150020US02
Technology
Assay to Determine Risk of Fungal Infection
Fungal infections such as aspergillosis and Valley Fever can be life threatening, particularly in immune-compromised patients. These patients are vulnerable to fungal strains that flourish in hospital...
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Bruce Klein, Marcel Wuethrich | P140236US02
Technology
Diagnostic Kit for Blastomycosis
Blastomyces dermatitidis is a soil fungus found throughout the world, and is especially prevalent in the river valleys and Great Lakes region of the United States. If spores are inhaled, blastomycosis...
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Bruce Klein, Theodore Brandhorst | P110280US02
Technology
Monoclonal and Polyclonal Antibodies Raised to Recombinant Mengovirus 3D Polymerase
Mengovirus is a picornavirus that causes encephalomyocarditis in humans and other animals.
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Ann Palmenberg, Hernando Duque | P97029US
Technology
Method and Compositions for Detecting Botulinum Neurotoxin
Botulinum neurotoxins produced by Clostridium botulinum are the most potent toxins known. Because of the threat of bio-terrorism, sensitive methods for detecting botulinum neurotoxin are needed; howev...
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Edwin Chapman, Min Dong | P04086US
Technology
Application of NADH Cytochrome B5 Reductase/System for Direct Metabolism of Xenobiotics
The NADH cytochrome b5 reductase/cytochrome b5 system can transfer electrons to other enzymes, including those involved in the metabolism of fatty acids, toxins and drugs. In the past, NADH cytochrome...
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Lauren Trepanier, Jackie Lynn Miller, Sunil Bajad, Joseph Raymond Kurian | P02388US