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61 Results for 'Differentiation'
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Technology
Methods for Generating Cardiac Fibroblasts
UW-Madison researchers have developed a defined and efficient method to direct the differentiation of epicardial cells to produce cardiac fibroblast cells. This builds on Dr. Palacek’s prior inn...
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Sean Palecek, Martha Floy | P210258US02
Technology
CHEMICAL COCKTAIL FOR INDUCING SENESCENCE IN HUMAN NEURONS TO PROMOTE DISEASE MODELING AND DRUG DISCOVERY
Provided herein are methods and compositions for inducing chemical senescence in neurons and methods of using chemically induced senescent neurons for modeling neurodegenerative disease and drug disco...
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Su-Chun Zhang, Ali Fathi | P200006US02
Technology
METHODS FOR CONTROLLED INDUCTION OF BIOENGINEERED NEUROEPITHELIAL TISSUES AND 3-D NEUROEPITHELIAL TUBES
Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into bioengineered elliptical neur...
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Randolph Ashton, Gavin Knight, Benjamin Knudsen, Nisha Iyer, Carlos Marti-Figueroa | P200307US03
Technology
GENERATION OF NOREPINEPHRINE NEURONS FROM HUMAN STEM CELLS
Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining g...
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Su-Chun Zhang, Yunlong Tao | P200364US02
Technology
Functional Neutrophils from Induced Pluripotent Stem Cells
Despite recent advances in prevention and management, myelosuppression and febrile neutropenia are a complication of cancer therapies and a common cause of morbidity and mortality, especially in pedia...
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Igor Slukvin, Vera Brok Volchanskaya, Kran Suknuntha, Anna Huttenlocher, David Bennin, Lucas Klemm | P190225US03
Technology
GENERATION OF HOXA-EXPRESSING HEMOGENIC ENDOTHELIUM WITH ENHANCED T CELL POTENTIAL FROM HPSCS
The present invention provides methods of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. The methods involve inducing the expression of...
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Igor Slukvin, Ho Sun Jung | P200133US02
Technology
Generating Arterial Endothelial Cell-Seeded Vascular Grafts
A frequent procedure in cardiovascular surgery is to replace or bypass a blood vessel in order to provide a more adequate flow of blood to downstream tissues. In operations that bypass coronary arteri...
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James Thomson, Jue Zhang, John Maufort | P180255US02
Technology
Methods For Cardiac Fibroblast Differentiation of Human Pluripotent Stem Cells
Cardiac fibroblasts (CF) comprise a major fraction of the total cells in the heart and can arise from mesodermal progenitor cells as the heart develops. CFs are primarily responsible for generating ex...
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Timothy Kamp, Jianhua Zhang | P160319US02
Technology
Method Of In Vitro Differentiation Of Neural Stem Cells, Motor Neurons And Dopamine Neurons From Pri
A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of ...
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Su-Chun Zhang, Xue-jun Li | P07445US
Technology
MYELOPOISIS FROM STEM CELLS
A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed.
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Igor Slukvin, Maksym Vodyanyk, Kyung-Dal Choi | P09078US02
Technology
GENERATION OF CLONAL MESENCHYMAL PROGENITORS AND MESENCHYMAL STEM CELL LINES UNDER SERUM-FREE CONDITIONS
Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.
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Igor Slukvin, Maksym Vodyanyk, Junying Yu, James Thomson | P07264US
Technology
METHOD FOR CULTURING STEM CELLS
A three-dimensional microwell system that supports long term pluripotent cell culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured pluripotent cells remain viabl...
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Timothy Kamp, Jianhua Zhang, Jeffrey Mohr, Juan DePablo, Sean Palecek | P08310US02
Technology
Methods Of Maintaining, Expanding, And Differentiating Neuronal Subtype Specific Progenitors
Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present in...
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Su-Chun Zhang, Zhong-wei Du | P150190US02
Technology
Methods And Devices For Differentiating Pluripotent Stem Cells Into Cells Of The Pancreatic Lineage
Methods and devices for culturing human pluripotent stem cells to produce cells of the pancreatic lineage are disclosed. The methods include steps of culturing the stem cells under conditions that ind...
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Jon Odorico, Xiaofang Xu | P110310US02
Technology
Substantially Pure Human Retinal Progenitor, Forebrain Progenitor, And Retinal Pigment Epithelium Cell Cultures And Methods Of Making The Same
Methods for producing substantially pure cultures of human neural retinal progenitor cells, forebrain progenitor cells, and retinal pigment epithelial cells are disclosed. In addition, the successful ...
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David Gamm, Jason Meyer | P09273US02
Technology
Controlling The Potential Of Primate Neural Stem Cells By Regulating Pax6
A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
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Su-Chun Zhang, Xiaoqing Zhang | P09295US03
Technology
Cardiac Differentiation Of Human Pluripotent Stem Cells Under Defined Conditions Using Matrix Overlay Methods
Methods for culturing the pluripotent stem cells to undergo epithelial-to-mesenchymal transition and for generating high-yield, high-purity cardiomyocyte cultures from pluripotent stem cells are descr...
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Timothy Kamp, Jianhua Zhang, Samira Azarin, Sean Palecek, Xiaojun Lian | P100142US02
Technology
Xeno-Free Generation Of Tissue-Specific Progenitor Cells
The invention relates to purified, tissue-specific progenitors, methods of making and using such tissue-specific progenitors.
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Peiman Hematti, Jaehyup Kim | P100234US02
Technology
Directed Differentiation Of Primate Pluripotent Stem Cells Into Functional Basal Forebrain Cholinergic Neurons (Bfcns) And Medium Spiny Gabaergic Projection Neurons
Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are disclosed.
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Su-Chun Zhang, Yan Liu, Lixiang Ma | P100266US02
Technology
Generation Of Cardiomyocytes From Human Pluripotent Stem Cells
Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, e.g.,...
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Sean Palecek, Timothy Kamp, Xiaojun Lian | P110259US02
Technology
Method Of Deriving Mature Hepatocytes From Human Embryonic Stem Cells
A method for producing mature hepatocytes having functional hepatic enzyme activity from human pluripotent cells is disclosed. The method includes the step of transferring an external vector that incl...
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James Thomson, Srikumar Sengupta | P120102US04
Technology
Chemically Defined Differentiation Protocol For Pericyte Differentiation From Pluripotent Stem Cells
The present invention provides methods of differentiating pericytes from pluripotent stem cells comprising culturing steps in chemically defined culture medium. A population of exogenously derived per...
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William Murphy, William Daly, Cheryl Soref, Elizabeth Torr, Elizabeth Aisenbrey, Hunter Johnson | P180159US02
Technology
Hydrogel Compositions For Use In Neural Cell Expansion And Differentiation
Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiatio...
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William Murphy, William Daly, Jonathan Evans, Elizabeth Aisenbrey, Elizabeth Torr | P160311US02
Technology
Generation Of Hematopoietic Progenitor Cells From Human Pluripotent Stem Cells
Methods for generating and using hematopoietic progenitor cells are described.
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James Thomson, Jue Zhang | P180326US02
Technology
Methods For Controlled Induction Of 3d Cylindrical Neuroepithelial Tubes
Described herein are methods, compositions, and kits for forming engineered in vitro biomimetic, three-dimensional, tubular organoid structures by directed differentiation of human pluripotent stem ce...
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Randolph Ashton, Carlos Marti-Figueroa | P190039US02