UW-Madison researchers have developed a reporter cell line for identifying compounds that promote endothelial cell differentiation and nitric oxide production and identified four compounds that promot...
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A UW-Madison researcher has developed an improved method for generating astrocyte cells from induced pluripotent stem cells (iPSCs). The new protocol is fast (15-20 days in culture) and produces ~100%...
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UW-Madison researchers have discovered a cell-surface marker (CD166) that can be used to distinguish (and purify) cells that are immature (early) cone photoreceptor precursor cells (CPPs), which will ...
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UW-Madison researchers have developed methods for deriving right ventricle-like cardiomyocytes from second heart field (SHF) cardiac progenitors. The addition of insulin or the inhibition of endogenou...
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UW-Madison researchers have developed methods for generating arterial hemogenic endothelium and hematopoietic progenitors using a 3D spheroid (75-150mM) “hanging drop” method, and they fou...
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UW-Madison researchers have discovered that inducing SOX18 expression in hPSCs during hematopoietic differentiation promotes specification and expansion of erythromyeloid progenitors, megakaryocytes a...
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A research collaboration between UW-Madison and the University of Bern has resulted in a new protocol for generating cells that can be used to better model the response and behavior of immune cells in...
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UW-Madison researchers have discovered that using allogenic arterial endothelial cells (not genetically modified to alter the immune response) perform better than hypoimmunogenic cells for producing s...
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UW-Madison researchers have developed methods for preparing PTP1b-deficient neutrophils, which exhibit improved recruitment and antimicrobial functions. The inventors employed CRISPR/Cas9 to delete PT...
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UW-Madison researchers have developed methods for generating SIRPα-KO macrophages with superior anti-tumor activity, and SIRPα-knockout neutrophils with superior anti-bacterial and anti-tu...
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The inventors have developed a novel system for co-differentiation of hepatocytes and hematopoietic progenitors from human embryonic stem cells (ES cells) that mimics a late fetal liver undergoing hem...
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UW-Madison researchers have developed a defined and efficient method to direct the differentiation of epicardial cells to produce cardiac fibroblast cells. This builds on Dr. Palacek’s prior inn...
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Provided herein are methods and compositions for inducing chemical senescence in neurons and methods of using chemically induced senescent neurons for modeling neurodegenerative disease and drug disco...
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Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells, neuromesodermal progenitors, and neural stem cells into bioengineered elliptical neur...
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Methods for obtaining populations of norepinephrine (NE) neuronal progenitor cells and creating enriched populations of NE neurons are provided herein. Also provided herein are methods for obtaining g...
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Despite recent advances in prevention and management, myelosuppression and febrile neutropenia are a complication of cancer therapies and a common cause of morbidity and mortality, especially in pedia...
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The present invention provides methods of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. The methods involve inducing the expression of...
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Cardiac fibroblasts (CF) comprise a major fraction of the total cells in the heart and can arise from mesodermal progenitor cells as the heart develops. CFs are primarily responsible for generating ex...
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A frequent procedure in cardiovascular surgery is to replace or bypass a blood vessel in order to provide a more adequate flow of blood to downstream tissues. In operations that bypass coronary arteri...
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A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed.
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A three-dimensional microwell system that supports long term pluripotent cell culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured pluripotent cells remain viabl...
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Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.
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Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present in...
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Methods and devices for culturing human pluripotent stem cells to produce cells of the pancreatic lineage are disclosed. The methods include steps of culturing the stem cells under conditions that ind...
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Methods for generating human arterial endothelial cells under defined conditions in the absence of insulin are described.
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