Wisconsin Alumni Research Foundation

Technology

HUMAN BLOOD-BRAIN BARRIER MODEL FOR IMMUNOLOGICAL STUDIES

A research collaboration between UW-Madison and the University of Bern has resulted in a new protocol for generating cells that can be used to better model the response and behavior of immune cells in...
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Eric Shusta, Hideaki Nishihara, Benjamin Gastfriend, Sean Palecek, Britta Engelhardt | P200363US03

Technology

SIRPα Inhibited Macrophages and Neutrophils and Uses Thereof

UW-Madison researchers have developed methods for generating SIRPα-KO macrophages with superior anti-tumor activity, and SIRPα-knockout neutrophils with superior anti-bacterial and anti-tumor activi...
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Igor Slukvin, Portia Smith, Aditi Majumder, Anna Huttenlocher, David Bennin | P220110US02

Technology

Methods for Generating Cardiac Fibroblasts

UW-Madison researchers have developed a defined and efficient method to direct the differentiation of epicardial cells to produce cardiac fibroblast cells. This builds on Dr. Palacek’s prior innovat...
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Sean Palecek, Martha Floy | P210258US02

Technology

Functional Neutrophils from Induced Pluripotent Stem Cells

Despite recent advances in prevention and management, myelosuppression and febrile neutropenia are a complication of cancer therapies and a common cause of morbidity and mortality, especially in pedia...
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Igor Slukvin, Vera Brok Volchanskaya, Kran Suknuntha, Anna Huttenlocher, David Bennin, Lucas Klemm | P190225US03

Technology

MYELOPOISIS FROM STEM CELLS

A method for efficient generation of neutrophils, eosinophils, macrophages, osteoclasts, dendritic cells an Langerhans cells from human embryonic stem cells is disclosed.
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Igor Slukvin, Maksym Vodyanyk, Kyung-Dal Choi | P09078US02

Technology

METHOD FOR CULTURING STEM CELLS

A three-dimensional microwell system that supports long term pluripotent cell culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured pluripotent cells remain viabl...
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Timothy Kamp, Jianhua Zhang, Jeffrey Mohr, Juan DePablo, Sean Palecek | P08310US02

WARF