Wisconsin Alumni Research Foundation

Technology

Knockout of GFAP In the Mouse (Model tm1Mes)

UW-Madison researchers have developed a GFAP knockout mouse model, designated tm1Mes, that has been engineered to have an internal deletion of the Gfap gene that renders it completely non-functional. ...
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Albee Messing, Maureen McCall | P220164US01

Technology

Lesion Volume Measurements System

An apparatus for measuring lesion volume, for example, in laboratory animals, provides a mirror box allowing a camera to simultaneously acquire profiles of the lesion along at least two crossing axes ...
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Randall Kimple, Junzhou Chen, Hunter Higby, Ryan Wisth, Kyuhyun Lee, Jeremy Rogers | P190262US02

Technology

Blood-Brain Barrier Model

Accurately reproducing the blood-brain barrier in an in vitro setting has been a longstanding challenge. Current methods require the independent isolation of multiple cell types, and the quality of th...
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Eric Shusta, Clive Svendsen, Christian Weidenfeller | P06318US02

Technology

Dramatically More Sensitive Ion Channel Antenna

Nearly half of all diseases involve ion channels – channels in cell membranes that control the flow of ions into and out of cells. Certain channels open in response to natural signal molecules as we...
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Robert Blick, Abhishek Bhat | P130074US01

Technology

Enhanced Blood-Brain Barrier Model Outperforms All Others

The blood-brain barrier (BBB) is made up of brain microvascular endothelial cells (BMECs), which line brain capillaries and control trafficking between the bloodstream and neural tissue. Although esse...
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Eric Shusta, Samira Azarin, Sean Palecek, Ethan Lippmann | P130017US02

Technology

Patch Clamp Providing On-Chip Thermal Control

Approximately half of all diseases affect the function of ion channels in cell membranes. Testing the flow of ions and molecules through these membranes clearly is vital to drug discovery and research...
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Robert Blick | P110325US01

Technology

Common Variants of the Sodium Channel Alpha Subunits

The SCN5A gene encodes a human cardiac sodium (Na+) channel alpha subunit that carries the inward Na+ current in the heart. Three distinct polymorphic SCN5A clones, hH1, hH1a and hH1b, have been isola...
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Jonathan Makielski, Bin Ye, Michael Ackerman | P02284US

WARF