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263 Results for 'Therapeutics & Vaccines'
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Technology
Crystallized Vitamin D Compound Known as “20DCM”
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
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Hector DeLuca, Agnieszka Glebocka, James Thoden, Hazel Holden | P100319US02
Technology
Benzodiazepine Derivatives with Reduced Side Effects for Treatment of Neuropathic Pain
Neuropathic pain encompasses a wide range of painful conditions of diverse origins, including diabetic neuropathy, post herpatic neuralgia, post-surgical nerve injuries and many others. Currently ther...
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James Cook, Rahul Edwankar, Shengming Huang, Zhi-Jian Wang, Ojas Namjoshi | T09021US02
Technology
A Supply of the Antibiotic Oligomycin
Oligomycin is a highly stable macrolide antibiotic isolated from the fungus Streptomyces diastochromogenes. It is a potent inhibitor of mitochondrial ATPase and phosphoryl group transfer.
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Glenn Chambliss | P04054US
Technology
Inhibitors of Ebola and Other Filoviruses
Ebola, a negative strand RNA virus in the family Filoviridae, is among the most lethal human pathogens, causing death in 50 to 90 percent of cases. This virus is highly contagious in aerosol form and ...
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Yoshihiro Kawaoka, Shinji Watanabe, Yasuko Hatta | P09098US02
Technology
Small Molecule Therapeutics to Inhibit HPV Infection
Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens. These small DNA viruses are associated with almost all cervical cancers and 20 to 30 percent of head and neck cancers....
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Paul Ahlquist, Paul Lambert, Dohun Pyeon, Shane Pearce | P07490US02
Technology
Novel Tautomycetin Analogs Specifically Inhibit SHP-2, May Provide New Cancer Treatment
SHP-2 is an oncogene from the protein tyrosine phosphatase (PTP) superfamily. Mutations in SHP-2 can cause multiple forms of leukemia and solid tumors, as well as the autosomal dominant disorders...
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Ben Shen, Zhong-Yin Zhang | P100290US03
Technology
Novel Tautomycetin Analogs Provide Potential Natural Products for the Treatment of Cancer or Autoimmune Disease
Tautomycetin (TTN) is a complex polyketide natural product produced by Streptomyces griseochromogens. It specifically inhibits the protein phosphatases PP1 and PP2A, which are two of the four maj...
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Ben Shen | P100341US02
Technology
Click Chemistry-Based Multi-Enhanced Biomaterials Help Heal Wounds
Wound healing is a complex and dynamic process of rebuilding skin and tissue. Chronic or impaired wounds result when tissues fail to progress through the necessary stages of healing. This is a signifi...
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Weiyuan John Kao, Yao Fu | P100330US02
Technology
Vitamin D Analog for Cancer Prevention and Treatment
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
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Hector DeLuca, Katarzyna Barycka, Katarzyna Plonska-Ocypa, Rafal Barycki, Lori Plum, Margaret Clagett-Dame, Izabela Sibilska-Kaminski, Rafal Sicinski | P100077US02
Technology
Crystallized Vitamin D Compound Known as “NEL”
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
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Hector DeLuca, Pawel Grzywacz, James Thoden, Hazel Holden | P100329US02
Technology
Bisphosphonates Inhibit Aneurysm Formation and Growth
Aortic aneurysms are weakened or bulging areas in the aorta, the largest blood vessel in the body. As many as 30,000 deaths may result from ruptured abdominal aortic aneurysms each year, but no ...
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Dai Yamanouchi, K. Craig Kent, Bo Liu | P100193US02
Technology
Prostate Cancer and Melanoma Screening
Almost 200,000 men in the United States develop prostate cancer each year. More than 60,000 people develop melanoma. Early diagnosis is key to survival because the best treatment and prognosis for the...
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Douglas McNeel, Edward Dunphy, Jason Dubovsky, Luke Hoeppner | P06004US
Technology
Antibacterial Agents Using Small Molecule Macroarrays
Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually a...
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Helen Blackwell, Matthew Bowman, Jennifer Campbell Butler, Joseph Stringer | P06361US
Technology
Protein Receptors for Botulinum Neurotoxin E (BoNT/E) Enable Means of Reducing BoNT/E Toxicity
Botulinum neurotoxins (BoNTs), the most potent toxins known, are among the most dangerous potential bioterrorism threats. They cause botulism, a severe disease that can cause paralysis in humans...
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Edwin Chapman, Min Dong | P08369US02
Technology
Hyperstable Collagen Mimics
Collagen, the most abundant protein in vertebrates, serves as the fundamental structural protein for vertebrate tissues. Collagen is a fibrous protein consisting of three polypeptide chains that fold ...
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Ronald Raines, Jonathan Hodges | P03226US
Technology
Novel Antibacterial Agents That Modulate Quorum Sensing and Are Effective at Physiological pH
Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules into the environment. When a certain nu...
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Helen Blackwell, Christine McInnis | P09045US02
Technology
Method to Increase Feed Efficiency by Reducing Endotoxin-Induced GI Tract Inflammation
Pathogenic bacteria in the gastrointestinal tract can induce inflammatory responses that negatively affect the ability of animals to efficiently digest food and absorb nutrients. Endotoxin, a characte...
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Mark Cook, Mingder Yang, David Barnes | P03399US
Technology
Plasmids Encoding Avian Influenza Genes
Avian influenza causes significant economic losses for poultry producers worldwide and can be transmitted to humans and other mammals. The surface glycoproteins hemagglutinin (HA) and neuraminidase (N...
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Yoshihiro Kawaoka | P06123US
Technology
High Titer Recombinant Influenza Viruses for Vaccines and Gene Therapy
Influenza is a major disease in humans that can be prevented by vaccination. Because new epidemic strains arise every year or two, the conventional influenza vaccine must be adapted almost every year,...
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Yoshihiro Kawaoka | P03322US
Technology
High Titer Recombinant Influenza Viruses for Vaccines
Influenza is caused by the eight-segmented influenza virus. Vaccines can be used to prevent influenza, but traditional methods for producing influenza vaccine are slow and cumbersome.
To generate re...
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Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami | P06370US
Technology
Improved Production of Influenza Virus, Including H1N1, for Vaccine Manufacture
The H1N1 influenza virus, known as the “swine flu,” has been declared a pandemic. While this virus is less virulent than many circulating strains of flu virus, it has become the subj...
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Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami | P100078US02
Technology
Attenuated Influenza Viruses for Development of Live Influenza Vaccine
Influenza is a major disease in humans that can be prevented by vaccination. Because new epidemic strains arise every year or two, influenza vaccines must be adapted almost every year. Live atte...
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Yoshihiro Kawaoka, Hatice Akarsu, Kiyoko Horimoto | P09022US02
Technology
Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria
Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules, including low molecular weight ligands...
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Helen Blackwell, Grant Geske, Jennifer Campbell Butler | P07404US
Technology
2-Methylene-18,19-Dinor-1Alpha-Hydroxy-Homopregnacalciferol
Vitamin D is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. A recently discovered class of vitamin D analogs, the 19-nor-vitamin D compound...
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Hector DeLuca, Lori Plum, Rafal Barycki, Margaret Clagett-Dame | P05147US
Technology
2-Methylene-19-Nor-1Alpha-Hydroxy-17-Ene-Homopregnacalciferol
Vitamin D is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. A recently discovered class of vitamin D analogs, the 19-nor-vitamin D compound...
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Hector DeLuca, Lori Plum, Bulli Padmaja Tadi, Margaret Clagett-Dame | P05148US