Wisconsin Alumni Research Foundation

Technology

Vitamin D Analogs for Treating Bone Cancers and Diseases

The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Izabela Sibilska-Kaminski, Rafal Sicinski | P100358US03

Technology

Treating Pulmonary Disorders with Artificial Lung Surfactant

Lung surfactant (LS) is a lipid-protein mixture that coats the internal surface of the lungs. It reduces the work of breathing by helping to keep air sacs open and stable. Deficient or dysfunctional L...
Learn More
Samuel Gellman, Shannon Stahl, Brendan Mowery, Annelise Barron, Michelle Dohm | P100038US02

Technology

Crystallized Vitamin D Compound Known as “20DCM”

The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Hector DeLuca, Agnieszka Glebocka, James Thoden, Hazel Holden | P100319US02

Technology

A Supply of the Antibiotic Oligomycin

Oligomycin is a highly stable macrolide antibiotic isolated from the fungus Streptomyces diastochromogenes. It is a potent inhibitor of mitochondrial ATPase and phosphoryl group transfer.
Learn More
Glenn Chambliss | P04054US

Technology

Inhibitors of Ebola and Other Filoviruses

Ebola, a negative strand RNA virus in the family Filoviridae, is among the most lethal human pathogens, causing death in 50 to 90 percent of cases. This virus is highly contagious in aerosol form and ...
Learn More
Yoshihiro Kawaoka, Shinji Watanabe, Yasuko Hatta | P09098US02

Technology

Small Molecule Therapeutics to Inhibit HPV Infection

Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens. These small DNA viruses are associated with almost all cervical cancers and 20 to 30 percent of head and neck cancers....
Learn More
Paul Ahlquist, Paul Lambert, Dohun Pyeon, Shane Pearce | P07490US02

Technology

Vitamin D Analog for Cancer Prevention and Treatment

The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Hector DeLuca, Katarzyna Barycka, Katarzyna Plonska-Ocypa, Rafal Barycki, Lori Plum, Margaret Clagett-Dame, Izabela Sibilska-Kaminski, Rafal Sicinski | P100077US02

Technology

Crystallized Vitamin D Compound Known as “NEL”

The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone...
Learn More
Hector DeLuca, Pawel Grzywacz, James Thoden, Hazel Holden | P100329US02

Technology

Prostate Cancer and Melanoma Screening

Almost 200,000 men in the United States develop prostate cancer each year. More than 60,000 people develop melanoma. Early diagnosis is key to survival because the best treatment and prognosis for the...
Learn More
Douglas McNeel, Edward Dunphy, Jason Dubovsky, Luke Hoeppner | P06004US

Technology

Method for Modulating Microbial Quorum Sensing

Bacteria that use quorum sensing are thought to be involved in two thirds of human bacterial infections. These bacteria produce acyl-homoserine lactones (AHL), which they use to gauge population densi...
Learn More
Jo Handelsman, Bradley Borlee | P04217US02

Technology

Antibacterial Agents Using Small Molecule Macroarrays

Staphylococcus aureus is a Gram-positive bacterium responsible for many infectious diseases, including toxic shock syndrome, food poisoning and topical skin infections. Although S. aureus is usually a...
Learn More
Helen Blackwell, Matthew Bowman, Jennifer Campbell Butler, Joseph Stringer | P06361US

WARF