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260 Results for 'Therapeutics & Vaccines'
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Technology
Cytotoxic Ribonuclease Variants
Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Ronald Raines, Julie Mitchell, Thomas Rutkoski | P04427US
Technology
Cell Line for Evaluating Influenza Virus Sensitivity to NA Inhibitors
The extensive use of neuraminidase (NA) inhibitors to treat influenza virus infections by reducing viral sialidase activity requires close monitoring for resistant variants. However, cultured cells do...
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Yoshihiro Kawaoka | P05278US
Technology
Multilayer Tissue Regeneration System
Under physiological conditions, bone tissue regeneration involves a complex interplay of multiple biologically active molecules and stem cells. The molecules are often presented sequentially in cascad...
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William Murphy | P05256US
Technology
Method and System for Delivering Nucleic Acid into a Target Cell
The normal growth and development of tissue requires a complex interplay of multiple signals from multiple genes in well-defined locations, leading to the controlled differentiation of precursor cells...
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William Murphy, Siyoung Choi | P06064US
Technology
Nanoparticles That Target Dendritic Cells
Dendritic cells play an important role in the process of initiating immune response. They are present in small quantities in tissues, such as skin and lung, that are in contact with the external envir...
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Ferencz Denes, Zsuzsanna Fabry, Matyas Sandor | P07026US
Technology
Stable Collagen Mimics
Collagen, the most abundant protein in vertebrates, provides structure for tissues and plays a key role in wound healing. In connective tissue, individual collagen molecules are wound together in tigh...
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Ronald Raines, Matthew Shoulders, Jonathan Hodges | P06406US
Technology
Novel Candidates for an Improved Tuberculosis Vaccine
Approximately one-third of the world’s population is infected with the bacterium Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). Five to 10 percent of non-immunocompr...
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Adel Talaat, Bassam Abomoelak, Sarah Ward | P09203US02
Technology
Novel Antibacterial Small Molecules
As the incidence of antibiotic resistance among bacteria continues to rise, the discovery of new antibacterial compounds has become increasingly critical to fighting infectious disease. According to t...
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Helen Blackwell, Matthew Bowman, Joseph Stringer | P07517US
Technology
Strong, Stable, Semisynthetic Collagen Mimic for Wound Healing, Artificial Skin, Sutures and Leather
Collagen is the most abundant protein in vertebrates. It serves as the fundamental structural protein for vertebrate tissues and is critically important in wound healing. Many diseases, including arth...
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Ronald Raines, Frank Kotch | P08274US
Technology
Tat-Utrophin as a Protein Therapy for Muscular Dystrophies
No effective therapy currently exists for the most common and severe form of muscular dystrophy disease, Duchenne Muscular Dystrophy (DMD). This disease, which is characterized by the weakening of vol...
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James Ervasti, Kevin Sonnemann | P06414US