Search Results
289 Results for 'Therapeutics & Vaccines'
PAGE 11 OF 12
Technology
Modified Retinoid Compounds with Reduced Toxicity
Orally administered retinoic acid isomers are used to treat many disorders; however, they cause serious side effects including weight loss, inanition, eye encrustation, bone loss, mucocutaneous toxici...
Learn More
Learn More
Margaret Clagett-Dame, Hector DeLuca, Sumithra Gowlugari | P02381US
Technology
Antimicrobial Polymers
The emergence of bacteria that are resistant to common therapeutic agents has resulted in a dire need for new antimicrobial compounds. One potential source of new antimicrobials is amphiphilic pe...
Learn More
Learn More
Samuel Gellman, Michael Gelman, Bernard Weisblum, David Lynn | P03315US
Technology
Hyperstable Collagen Mimics
Collagen, the most abundant protein in vertebrates, serves as the fundamental structural protein for vertebrate tissues. Collagen is a fibrous protein consisting of three polypeptide chains that fold ...
Learn More
Learn More
Ronald Raines, Jonathan Hodges | P03226US
Technology
Novel Antibacterial Agents That Modulate Quorum Sensing and Are Effective at Physiological pH
Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules into the environment. When a certain nu...
Learn More
Learn More
Helen Blackwell, Christine McInnis | P09045US02
Technology
Method to Increase Feed Efficiency by Reducing Endotoxin-Induced GI Tract Inflammation
Pathogenic bacteria in the gastrointestinal tract can induce inflammatory responses that negatively affect the ability of animals to efficiently digest food and absorb nutrients. Endotoxin, a characte...
Learn More
Learn More
Mark Cook, Mingder Yang, David Barnes | P03399US
Technology
Plasmids Encoding Avian Influenza Genes
Avian influenza causes significant economic losses for poultry producers worldwide and can be transmitted to humans and other mammals. The surface glycoproteins hemagglutinin (HA) and neuraminidase (N...
Learn More
Learn More
Yoshihiro Kawaoka | P06123US
Technology
High Titer Recombinant Influenza Viruses for Vaccines
Influenza is caused by the eight-segmented influenza virus. Vaccines can be used to prevent influenza, but traditional methods for producing influenza vaccine are slow and cumbersome.
To generate re...
Learn More
Learn More
Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami | P06370US
Technology
High Titer Recombinant Influenza Viruses for Vaccines and Gene Therapy
Influenza is a major disease in humans that can be prevented by vaccination. Because new epidemic strains arise every year or two, the conventional influenza vaccine must be adapted almost every year,...
Learn More
Learn More
Yoshihiro Kawaoka | P03322US
Technology
Improved Reverse Genetics Method to Produce Influenza Virus
Influenza causes hundreds of thousands of deaths worldwide every year. Two of the genes critical for influenza virus infection are haemagglutinin (HA) and neuraminidase (NA). HA and NA are on the surf...
Learn More
Learn More
Yoshihiro Kawaoka, Gabriele Neumann | P04379US
Technology
Improved Production of Influenza Virus, Including H1N1, for Vaccine Manufacture
The H1N1 influenza virus, known as the “swine flu,” has been declared a pandemic. While this virus is less virulent than many circulating strains of flu virus, it has become the subj...
Learn More
Learn More
Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami | P100078US02
Technology
Attenuated Influenza Viruses for Development of Live Influenza Vaccine
Influenza is a major disease in humans that can be prevented by vaccination. Because new epidemic strains arise every year or two, influenza vaccines must be adapted almost every year. Live atte...
Learn More
Learn More
Yoshihiro Kawaoka, Hatice Akarsu, Kiyoko Horimoto | P09022US02
Technology
Synthetic Ligands Capable of Strongly Inhibiting or Inducing Quorum Sensing in Bacteria
Quorum sensing is a process used by some bacteria to coordinate behavior based on local population density. To communicate, bacteria release signaling molecules, including low molecular weight ligands...
Learn More
Learn More
Helen Blackwell, Grant Geske, Jennifer Campbell Butler | P07404US
Technology
2-Methylene-18,19-Dinor-1Alpha-Hydroxy-Homopregnacalciferol
Vitamin D is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. A recently discovered class of vitamin D analogs, the 19-nor-vitamin D compound...
Learn More
Learn More
Hector DeLuca, Lori Plum, Rafal Barycki, Margaret Clagett-Dame | P05147US
Technology
2-Methylene-19-Nor-1Alpha-Hydroxy-17-Ene-Homopregnacalciferol
Vitamin D is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. A recently discovered class of vitamin D analogs, the 19-nor-vitamin D compound...
Learn More
Learn More
Hector DeLuca, Lori Plum, Bulli Padmaja Tadi, Margaret Clagett-Dame | P05148US
Technology
Method to Diagnose and Treat Degenerative Joint Disease
Joint disease results in huge economic costs and can significantly reduce the quality-of-life of people who suffer from it. Pain, inflammation, and instability of the joint are common. Treatment is ge...
Learn More
Learn More
Peter Muir, Ray Vanderby, Paolo Provenzano | P03092US
Technology
Glycomacropeptide (GMP)-Based Food for the Treatment of PKU and Other Metabolic Disorders
Phenylketonuria (PKU) is a genetic disorder in which an individual lacks the enzyme phenylalanine hydroxylase (PAH) that converts the amino acid phenylalanine into tyrosine. If left untreated, t...
Learn More
Learn More
Denise Ney, Mark Etzel | P09323US02
Technology
Spatial Control of Signal Transduction
Development of most tissue types involves a complex interplay of multiple growth factors in well defined locations, leading to controlled differentiation of precursor cells into mature, tissue-specifi...
Learn More
Learn More
William Murphy, Gregory Hudalla | P05255US
Technology
Cytotoxic Ribonuclease Variants
Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
Learn More
Learn More
Ronald Raines, Julie Mitchell, Thomas Rutkoski | P04427US
Technology
Cytotoxic Ribonuclease Variants
Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
Learn More
Learn More
Ronald Raines, George Phillips, R. Jeremy Johnson, Jason McCoy | P05341US
Technology
Cell Line for Evaluating Influenza Virus Sensitivity to NA Inhibitors
The extensive use of neuraminidase (NA) inhibitors to treat influenza virus infections by reducing viral sialidase activity requires close monitoring for resistant variants. However, cultured cells do...
Learn More
Learn More
Yoshihiro Kawaoka | P05278US
Technology
Multilayer Tissue Regeneration System
Under physiological conditions, bone tissue regeneration involves a complex interplay of multiple biologically active molecules and stem cells. The molecules are often presented sequentially in cascad...
Learn More
Learn More
William Murphy | P05256US
Technology
Method and System for Delivering Nucleic Acid into a Target Cell
The normal growth and development of tissue requires a complex interplay of multiple signals from multiple genes in well-defined locations, leading to the controlled differentiation of precursor cells...
Learn More
Learn More
William Murphy, Siyoung Choi | P06064US
Technology
Reverse Genetics Approach for Generating Ebola Virus and Other Filoviruses from Cloned DNA
Ebola virus, a negative strand RNA virus in the family Filoviridae, is among the most lethal human pathogens. Efforts to develop treatments for Ebola infections have been hampered by a lack of effecti...
Learn More
Learn More
Yoshihiro Kawaoka, Gabriele Neumann, Luke Jasenosky | P01214US
Technology
Nanoparticles That Target Dendritic Cells
Dendritic cells play an important role in the process of initiating immune response. They are present in small quantities in tissues, such as skin and lung, that are in contact with the external envir...
Learn More
Learn More
Ferencz Denes, Zsuzsanna Fabry, Matyas Sandor | P07026US
Technology
Using Anti-Estrogens to Treat Cervical or Vaginal Cancer and Dysplasia
More than 11,000 American women were diagnosed with cervical cancer in 2008. Treatment of this disease, which consists of surgical, chemotherapeutic and radiation therapies, costs an estimated $1.7 bi...
Learn More
Learn More
Paul Lambert, Sang Hyuk Chung | P09292US03