Wisconsin Alumni Research Foundation

Technology

Modified Retinoid Compounds with Reduced Toxicity

Orally administered retinoic acid isomers are used to treat many disorders; however, they cause serious side effects including weight loss, inanition, eye encrustation, bone loss, mucocutaneous toxici...
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Margaret Clagett-Dame, Hector DeLuca, Sumithra Gowlugari | P02381US

Technology

Antimicrobial Polymers

The emergence of bacteria that are resistant to common therapeutic agents has resulted in a dire need for new antimicrobial compounds. One potential source of new antimicrobials is amphiphilic pe...
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Samuel Gellman, Michael Gelman, Bernard Weisblum, David Lynn | P03315US

Technology

Hyperstable Collagen Mimics

Collagen, the most abundant protein in vertebrates, serves as the fundamental structural protein for vertebrate tissues. Collagen is a fibrous protein consisting of three polypeptide chains that fold ...
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Ronald Raines, Jonathan Hodges | P03226US

Technology

Plasmids Encoding Avian Influenza Genes

Avian influenza causes significant economic losses for poultry producers worldwide and can be transmitted to humans and other mammals. The surface glycoproteins hemagglutinin (HA) and neuraminidase (N...
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Yoshihiro Kawaoka | P06123US

Technology

High Titer Recombinant Influenza Viruses for Vaccines

Influenza is caused by the eight-segmented influenza virus. Vaccines can be used to prevent influenza, but traditional methods for producing influenza vaccine are slow and cumbersome. To generate re...
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Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami | P06370US

Technology

2-Methylene-18,19-Dinor-1Alpha-Hydroxy-Homopregnacalciferol

Vitamin D is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. A recently discovered class of vitamin D analogs, the 19-nor-vitamin D compound...
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Hector DeLuca, Lori Plum, Rafal Barycki, Margaret Clagett-Dame | P05147US

Technology

Spatial Control of Signal Transduction

Development of most tissue types involves a complex interplay of multiple growth factors in well defined locations, leading to controlled differentiation of precursor cells into mature, tissue-specifi...
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William Murphy, Gregory Hudalla | P05255US

Technology

Cytotoxic Ribonuclease Variants

Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Ronald Raines, Julie Mitchell, Thomas Rutkoski | P04427US

Technology

Cytotoxic Ribonuclease Variants

Ribonucleases are enzymes that catalyze the degradation of RNA. Levels of RNase activity are controlled in vivo by a ribonuclease inhibitor (RI), which binds strongly to an RNase to completely inhibit...
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Ronald Raines, George Phillips, R. Jeremy Johnson, Jason McCoy | P05341US

Technology

Multilayer Tissue Regeneration System

Under physiological conditions, bone tissue regeneration involves a complex interplay of multiple biologically active molecules and stem cells. The molecules are often presented sequentially in cascad...
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William Murphy | P05256US

Technology

Nanoparticles That Target Dendritic Cells

Dendritic cells play an important role in the process of initiating immune response. They are present in small quantities in tissues, such as skin and lung, that are in contact with the external envir...
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Ferencz Denes, Zsuzsanna Fabry, Matyas Sandor | P07026US

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