UW-Madison researchers, in collaboration with a professor from the University of Missouri, propose using the cryptic lineages (4-24 amino acid substitutions) of the SARS-CoV-2 spike protein sequence t...
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UW-Madison researchers have developed a SARS-CoV-2 live-attenuated vaccine virus based on the original Wuhan genome but lacking the envelope (E) open reading frame. This vaccine virus replicates effic...
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UW-Madison researchers have developed a series of mutant influenza B viruses that incorporate mutations in the HA1 protein that cause the virus to react with sera generated via exposure to the opposit...
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The present invention relates to novel IBV vaccines containing novel modified S and N antigens from avian coronaviruses. The modifications include: S has a modified transmembrane domain for better s...
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The present invention relates to a novel bivalent coronavirus/influenza virus vaccine (called CoroFlu). The vaccine comprises a coronavirus antigen (a secreted version of the spike (S) protein of SARS...
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UW researchers have identified the combination of TLR3 and TLR9 agonists as the most effective means of activating T cells and induing anti-tumor activity when used with a DNA vaccine to treat prostat...
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UW-Madison researchers successfully developed and demonstrated improved mRNA stabilization techniques that leverage mineral coatings. In short, the inventors stabilized mRNA complexes on mineral coate...
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The present invention by UW Madison researchers provides combination therapies and methods of treating cancer, including, cancers that are resistant to PD-1 therapy. The combination therapies describe...
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UW-Madison researchers have isolated and characterized a BA.2 strain of the Omicron variant of SARS-CoV-2.
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The present invention from UW Madison researchers provides compositions and methods of treating prostate cancer using a combination of a DNA vaccine, PD-1 inhibitor and an IDO inhibitor. Further, meth...
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UW-Madison researchers have isolated and characterized a BA.1 strain of the Omicron variant of SARS-CoV-2.
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UW – Madison researchers have determined that SARS-CoV-2 infection induces antibodies against both structural and non-structural proteins and they identified epitopes in the SARS-CoV-2 membrane ...
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The present invention provides both QuilA-loaded chitosan (QAC)-encapsulated DNA vaccine compositions and viral vaccine compositions that encode a SARs-CoV-2 spike (S) protein, a SARs-CoV-2 nucleocaps...
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The invention provides a vaccine comprising a recombinant biologically contained filovirus and methods of making and using those viruses.
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Ebola Virus Disease (EVD) is a severe and highly fatal hemorrhagic fever that affects humans and other mammals. It is caused by the Ebola virus, a single-stranded RNA virus that encodes seven structur...
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Most influenza vaccines are produced in embryonated chicken eggs, but increasingly influenza vaccines are produced in other systems. MDCK (Madin-Darby Canine Kidney) cells are one of two mammalian cel...
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Provided herein are antigenic peptides comprising the SARS-CoV-2 spike protein receptor binding domain (CRBD) polypeptide or portions thereof, linked to a non-catalytic, non­toxic tetanus toxin varia...
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The present disclosure relates to vims-like particles and vaccine compositions for inducing immunity and preventing respiratory syncytial vims (RSV) infection. Specifically, the disclosure provides vi...
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A method to prepare recombinant influenza viruses comprising a mutant M2 protein which has a deletion of two or more residues in the cytoplasmic tail and is attenuated in vivo, is provided, as well th...
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The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isola...
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The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isola...
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A vector, composition and method to improve influenza virus replication by inhibiting miRNA lec-7C binding to influenza virus mRNA and/or cRNA.
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Compositions and methods to prepare influenza virus-like particles (VLPs) are provided.
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It is disclosed herein that (a) an anti-tumor DNA vaccine delivered using a MIP DNA vector is a less effective tumor treatment than the corresponding anti-tumor DNA vaccine delivered using a conventio...
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The invention provides a vaccine comprising an effective amount of an isolated recombinant influenza virus comprising a mutant M gene segment that is mutated so that upon viral replication the mutant ...
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