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44 Results for 'Anti-infectives (antibacterials, antifungals, antivirals)'
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Technology
Synthetic Ligands that Modulate the Activity of the RhlR Quorum Sensing Receptor
UW Madison researchers have developed RhlR modulators including agonist and antagonists which are useful for modulating QS phenotypes in Gram-negative bacteria. Certain compounds of general formula A-...
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Helen Blackwell, Joseph Moore, Michelle Boursier | P160350US02
Technology
Protein Tyrosine Phosphatase 1B Inhibited Neutrophils, Neutrophil-Dendritic Cell Hybrids and Uses Thereof
UW-Madison researchers have developed methods for preparing PTP1b-deficient neutrophils, which exhibit improved recruitment and antimicrobial functions. The inventors employed CRISPR/Cas9 to delete PT...
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Igor Slukvin, Anna Huttenlocher, Morgan Giese, Ho Sun Jung, David Bennin | P220160US03
Technology
Development of Food-Grade Fungal Fermentates with Antimicrobial Activity
The present invention relates to a ‘sugar fermentate of edible fungi’ (i.e., cultures of GRAS species from the genus Aspergillus) that exhibits antimicrobial activity (e.g., against Lister...
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Jaehyuk Yu, Ahmad Alshannaq, Dasol Choi | P180291WO01
Technology
MODULAR DENDRON MICELLES FOR TREATMENT OF PULMONARY DISEASES RELATED TO FIBROSIS AND VIRAL INFECTION INCLUDING COVID-19
UW-Madison researchers have developed a dendron-micelle (DM) nanoparticle platform that can be used for combination therapy in the treatment of interstitial lung disease (ILD), including idiopathic pu...
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Seungpyo Hong, Allan Brasier, Weiping Tang | P210069US02
Technology
SIRPα Inhibited Macrophages and Neutrophils and Uses Thereof
UW-Madison researchers have developed methods for generating SIRPα-KO macrophages with superior anti-tumor activity, and SIRPα-knockout neutrophils with superior anti-bacterial and anti-tu...
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Igor Slukvin, Portia Smith, Aditi Majumder, Anna Huttenlocher, David Bennin | P220110US02
Technology
Peptides That Inhibit Infection By Sars-Cov-2, The Virus That Causes Covid-19 Disease
UW Madison researchers and collaborators have developed anti-SARS-CoV-2 α/β-polypeptides, pharmaceutical compositions containing the same, and methods to inhibit, treat, and ameliorate SARS...
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Samuel Gellman, Victor Outlaw, Anne Moscona, Matteo Porotto, Zhen Yu | P210396WO01
Technology
Turbinmicin Compounds And Compositions As Potent Antifungal Agents
The present invention from UW Madison inventors is a set of analogs of turbinmicin that show similar efficacy but are more soluble than the parent molecule. The parent molecule proved to be fairly ins...
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Timothy Bugni, Weiping Tang, Le Guo, Changgui Zhao, Fan Zhang, Douglas Braun, David Andes, Miao Zhao, Jenna Fossen | P200353WO01
Technology
System And Assay For Monitoring Production/Release Of Membrane-Lytic Toxins In Bacteria And Compounds For Modulating Same
The present technology from UW Madison innovators provides a system for monitoring quorum-sensing in bacteria comprising bacteria that release at least one membrane-lytic toxin when the bacteria are a...
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Helen Blackwell, Thomas Polaske, David Lynn, Curran Gahan, Kayleigh Bucci | P210088US02
Technology
Compositions And Methods Of Clostridiodides Difficile Treatment, Decolonization, And Prevention
The present technology from this UW Madison researcher is a germinant mixture that includes a) a bile acid main germinant, b) an amino acid co-germinant, c) an edible spore solubilizing agent, and d) ...
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Noah Budi | P210282US02
Technology
SARS-COV-2 OMICRON BA.2 VARIANT FOR MEDICAL COUNTERMEASURE EVALUATION
UW-Madison researchers have isolated and characterized a BA.2 strain of the Omicron variant of SARS-CoV-2.
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Yoshihiro Kawaoka | P220198US01
Technology
SARS-COV-2 BA.1 OMICRON VARIANT FOR MEDICAL COUNTERMEASURE EVALUATION
UW-Madison researchers have isolated and characterized a BA.1 strain of the Omicron variant of SARS-CoV-2.
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Yoshihiro Kawaoka, Peter Halfmann | P220159US01
Technology
Dual-Responsive Nanoparticles For Enhanced Antibacterial Efficacy
UW Madison researchers have provided herein biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacter...
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Shaoqin Gong, Mingzhou Ye, David Andes | P210016US02
Technology
Inhibitors Of Bacterial Pasta Kinases
Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.
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Robert Striker, Nathan Wlodarchak, John Feltenberger, Jennifer Golden | P180315US02
Technology
Generation of Wild Type and Mutant Ebola Virus from Cloned cDNA
Ebola Virus Disease (EVD) is a severe and highly fatal hemorrhagic fever that affects humans and other mammals. It is caused by the Ebola virus, a single-stranded RNA virus that encodes seven structur...
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Yoshihiro Kawaoka, Gabriele Neumann, Luke Jasenosky | P01214US02
Technology
Methods to Screen Antifungal Compounds and Treat Fungal Diseases by Inhibiting Spore Germination
Every year worldwide, millions of people experience morbidity and mortality as a consequence of severe fungal disease. In the United States, mortality from invasive fungal disease is approximately 50 ...
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Christina Hull, Mingwei Huang, Sébastien Ortiz | P180117US02
Technology
Ph-Responsive Polymer–Antibiotic Conjugate For Enhanced Antimicrobial Efficacy
Provided herein are polymer-drug conjugates with enhanced antibacterial efficacy. These conjugates include a polymer comprising a plurality of masked cationic functional groups and an antibiotic drug ...
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Shaoqin Gong, Mingzhou Ye | P200087US02
Technology
Reversible Natural Product Glycosyltransferase-catalyzed Reactions, Compounds And Related Methods
The present invention relates to methods of use of glycosyltransferases and related compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomol...
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Jon Thorson, Byron Griffith, Changsheng Zhang | P06427US
Technology
Simplified Structural Mimetics Of Aips As Quorum Sensing Inhibitors
Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or m...
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Helen Blackwell, Joseph Vasquez, Yiftah Tal Gan | P170030US02
Technology
High Titer Recombinant Influenza Viruses With Enhanced Replication In Mdck Or Vero Cells Or Eggs
The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isola...
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Yoshihiro Kawaoka, Gabriele Neumann, Jihui Ping | P130287US02
Technology
An Ionic Liquid-Based Nanoemulsion Formulation For The Efficient Delivery Of Hydrophobic Therapeutic Agents
The present invention discloses an ionic liquid composition comprising an at least partially hydrophobic ionic liquid, wherein the at least partially hydrophobic ionic liquid comprises a dication comp...
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Sandro Mecozzi, Moira Esson | P180283US02
Technology
Cyphomycin, Compositions And Uses Thereof
Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cypho...
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Cameron Currie, Timothy Bugni, Monica Pupo, David Andes, Humberto Ortega Dominguez | P180334US02
Technology
Use Of A Rotifer-Derived Compound And Its Analogs For Preventing Schistosomiasis
The present disclosure relates provides compounds according to Formula I or Formula II as well as compositions including such compounds useful for the prevention of schistosomiasis infection and/or sw...
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Phillip Newmark, Jonathan Sweedler, Ning Yang, Jiarong Gao, Peter Yau | P180311US02
Technology
Antifungal Compounds
Compounds of formula (I) or formula (II), compositions and methods useful for treating and/or preventing a fungal infections are provided. wherein the substituents are as defined in the appended claim...
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Cameron Currie, Ethan Van Amam, Clarissa Sit, Antonio Ruzzini, Jon Clardy, Adrian Pinto-Tomas | P170089US03
Technology
Circular Strained Zymogen Compositions And Methods Of Use
Disclosed herein are circular zymogens of RNase 1 that have a proteolytic cleavage site and are activated by a specific protease. These circular zymogens are useful for treatment of disorders that are...
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Ronald Raines, Ian Windsor | P190190US02
Technology
A Novel Series of Antimicrobials Target Bacteria Membranes to Overcome Antibiotic Resistance
Drug resistant pathogens continue to emerge as the rate of the development of new antimicrobials to combat them continues to decline. Alarmingly, slow-growing bacteria associated with dangerous and pr...
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Douglas Weibel, Ye Jin Eun, Marie Foss, Katherine Hurley | P120204US02