UW Madison researchers have developed RhlR modulators including agonist and antagonists which are useful for modulating QS phenotypes in Gram-negative bacteria. Certain compounds of general formula A-...
Learn More

UW-Madison researchers have developed methods for preparing PTP1b-deficient neutrophils, which exhibit improved recruitment and antimicrobial functions. The inventors employed CRISPR/Cas9 to delete PT...
Learn More

The present invention relates to a ‘sugar fermentate of edible fungi’ (i.e., cultures of GRAS species from the genus Aspergillus) that exhibits antimicrobial activity (e.g., against Lister...
Learn More

UW-Madison researchers have developed a dendron-micelle (DM) nanoparticle platform that can be used for combination therapy in the treatment of interstitial lung disease (ILD), including idiopathic pu...
Learn More

UW-Madison researchers have developed methods for generating SIRPα-KO macrophages with superior anti-tumor activity, and SIRPα-knockout neutrophils with superior anti-bacterial and anti-tu...
Learn More

UW Madison researchers and collaborators have developed anti-SARS-CoV-2 α/β-polypeptides, pharmaceutical compositions containing the same, and methods to inhibit, treat, and ameliorate SARS...
Learn More

The present invention from UW Madison inventors is a set of analogs of turbinmicin that show similar efficacy but are more soluble than the parent molecule. The parent molecule proved to be fairly ins...
Learn More

The present technology from UW Madison innovators provides a system for monitoring quorum-sensing in bacteria comprising bacteria that release at least one membrane-lytic toxin when the bacteria are a...
Learn More

The present technology from this UW Madison researcher is a germinant mixture that includes a) a bile acid main germinant, b) an amino acid co-germinant, c) an edible spore solubilizing agent, and d) ...
Learn More

UW-Madison researchers have isolated and characterized a BA.2 strain of the Omicron variant of SARS-CoV-2.
Learn More

UW-Madison researchers have isolated and characterized a BA.1 strain of the Omicron variant of SARS-CoV-2.
Learn More

UW Madison researchers have provided herein biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacter...
Learn More

Biochemically active PASTA kinase inhibitors which exploit subtle structural differences between human kinases and bacterial PASTA kinases to improve specificity and inhibitor activity.
Learn More

Ebola Virus Disease (EVD) is a severe and highly fatal hemorrhagic fever that affects humans and other mammals. It is caused by the Ebola virus, a single-stranded RNA virus that encodes seven structur...
Learn More

Every year worldwide, millions of people experience morbidity and mortality as a consequence of severe fungal disease. In the United States, mortality from invasive fungal disease is approximately 50 ...
Learn More

Provided herein are polymer-drug conjugates with enhanced antibacterial efficacy. These conjugates include a polymer comprising a plurality of masked cationic functional groups and an antibiotic drug ...
Learn More

The present invention relates to methods of use of glycosyltransferases and related compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomol...
Learn More

Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds are described in formulas I, II, III, IV, V and VI herein. One or m...
Learn More

The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isola...
Learn More

The present invention discloses an ionic liquid composition comprising an at least partially hydrophobic ionic liquid, wherein the at least partially hydrophobic ionic liquid comprises a dication comp...
Learn More

Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cypho...
Learn More

The present disclosure relates provides compounds according to Formula I or Formula II as well as compositions including such compounds useful for the prevention of schistosomiasis infection and/or sw...
Learn More

Compounds of formula (I) or formula (II), compositions and methods useful for treating and/or preventing a fungal infections are provided. wherein the substituents are as defined in the appended claim...
Learn More

Disclosed herein are circular zymogens of RNase 1 that have a proteolytic cleavage site and are activated by a specific protease. These circular zymogens are useful for treatment of disorders that are...
Learn More

Drug resistant pathogens continue to emerge as the rate of the development of new antimicrobials to combat them continues to decline. Alarmingly, slow-growing bacteria associated with dangerous and pr...
Learn More