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The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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Approximately 20 percent of human proteins – including many of high pharmaceutical relevance – are believed to contain disulfide bonds critical for proper structure and function. However, producin...
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Gram-negative bacterial infections are an ongoing challenge to health care providers worldwide. Detection, treatment and control of such pathogens have gained increasing importance in the context of a...
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Human immunodeficiency virus (HIV) affects over 1.2 million Americans each year, with approximately 50,000 new infections per year. Current treatment includes HIV combination regimens comprising rever...
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Influenza is responsible for hundreds of thousands of deaths worldwide every year. Vaccines can be used to prevent influenza, but traditional methods for producing influenza vaccine are slow and cumbe...
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Fungi produce a variety of chemical compounds called secondary metabolites that possess useful pharmaceutical properties. These compounds are invaluable platforms for developing front-line drugs. They...
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The ability to modulate interactions between proteins is an attractive goal for both research and therapeutic applications. Developing modulating agents using traditional small-molecule approaches is ...
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Fungi produce a variety of chemical compounds called secondary metabolites. These compounds display a broad range of activities, including fighting off other fungi and bacteria. They also are useful f...
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Many pharmaceuticals and other biologically active molecules contain chemical sequences called triads that are challenging to prepare in the laboratory. Specifically, triads are three or more contiguo...
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Influenza viruses instigate annual global epidemics. The first influenza pandemic in 40 years occurred during the 2009-2010 season, when a novel H1N1 strain emerged and spread worldwide. The United St...
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Asymmetric synthesis is important in the pharmaceutical industry because frequently only one optically active isomer, or enantiomer, is therapeutically active. Therefore, it is often desirable to sele...
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Suspension crystallization processes often result in crystals with a wide range of particle sizes.  Accurately controlling the distribution of shapes and sizes is a challenge in the pharmaceutica...
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Many of the compounds used in drug discovery by pharmaceutical companies are glycosylated, bacterial secondary metabolites. A glycosylated metabolite consists of a central core structure (aglycon) and...
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Many of the compounds used in drug discovery by pharmaceutical companies are glycosylated bacterial secondary metabolites. A glycosylated metabolite consists of a central core structure (aglycon) and ...
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The growth assay is the simplest, most direct measurement of drug efficacy, and is the primary path for discovering antimicrobial drugs. However, most growth assays use relatively large volumes of liq...
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Influenza A virus possesses two surface spike proteins, hemagglutinin (HA) and neuraminidase (NA). HA binds to sialic acid-containing receptors on host cell surfaces.  NA cleaves terminal sialic ...
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