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35 Results for 'Drug production & design'
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Technology
Synthesis Of Small Molecule Histone Deacetylase 6 Degraders, Compounds Formed Thereby, And Pharmaceutical Compositions Containing Them
Weiping Tang, Ka Yang, Hao Wu, Zhongrui Zhang | P180321US05
Technology
Synthesis Of Small Molecule Histone Deacetylase 6 Degraders, Compounds Formed Thereby, And Pharmaceutical Compositions Containing Them
Weiping Tang, Ka Yang, Hao Wu | P180321US03
Technology
Expansion And Maintenance Of Adult Primary Human Hepatocytes In Culture
James Thomson, Srikumar Sengupta | P180325US03
Technology
Coated Egg Yolk Cores, Methods Of Making And Methods Of Use Thereof
Mark Cook, Jordan Sand | P170345US01
Technology
Arogenate Dehydrogenase Polynucleotides, Polypeptides And Methods Of Using The Same
Hiroshi Maeda, Samuel Lopez Nieves, Marcos de Oliveira | P170120US02
Technology
Engineered Prephenate Dehydrogenases And Arogenate Dehydrogenases And Methods Of Using The Same
Hiroshi Maeda, Craig Schenck | P170121US02
Technology
Using Liquid Crystal To Detect Endotoxin In The Presence Of One Or More Potential Masking Agents
Nicholas Abbott, Abhijit Dan | P160072US02
Technology
Photochemical Methods Of Making Cyclobutane Boronates And Related Compounds
Tehshik Yoon, Spencer Scholz, Rowan Littlefield, Niecia Flikweert | P170290US02
Technology
Research Tool for Protein Conformation Analysis
The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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Michael Sussman, Juda Shohet, Faraz Choudhury, Joshua Blatz, Benjamin Minkoff, Daniel Benjamin | P160180US02
Technology
Yeast-Based Intein Platform for Drug Production
The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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Eric Shusta, Cathryn Marshall | P150056US02
Technology
Small Molecule Catalysts of Oxidative Protein Folding
Approximately 20 percent of human proteins – including many of high pharmaceutical relevance – are believed to contain disulfide bonds critical for proper structure and function. However, producin...
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Ronald Raines, John Lukesh | P150010US02
Technology
Enhanced Endotoxin Detection: New Advantages in Liquid Crystal Assays for Gram-Negative Pathogens
Gram-negative bacterial infections are an ongoing challenge to health care providers worldwide. Detection, treatment and control of such pathogens have gained increasing importance in the context of a...
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Nicholas Abbott, Abhijit Dan | P160072WO01
Technology
Better Living Through Peptides; Improved Approach to HIV Therapy
Human immunodeficiency virus (HIV) affects over 1.2 million Americans each year, with approximately 50,000 new infections per year. Current treatment includes HIV combination regimens comprising rever...
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Samuel Gellman, William Horne, Lisa Johnson | P08414US03
Technology
Efficient Generation of Influenza Virus with Adenoviral Vectors
Influenza is responsible for hundreds of thousands of deaths worldwide every year. Vaccines can be used to prevent influenza, but traditional methods for producing influenza vaccine are slow and cumbe...
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Yoshihiro Kawaoka, Makoto Ozawa | P06444US
Technology
New System for Producing Fungal Secondary Metabolites
Fungi produce a variety of chemical compounds called secondary metabolites that possess useful pharmaceutical properties. These compounds are invaluable platforms for developing front-line drugs. They...
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Nancy Keller, Philipp Wiemann | P150029US02
Technology
Peptide Mimics Last Longer, Target Protein-Protein Interactions
The ability to modulate interactions between proteins is an attractive goal for both research and therapeutic applications. Developing modulating agents using traditional small-molecule approaches is ...
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Samuel Gellman, James Checco | P140148US02
Technology
Increasing Secondary Metabolite Production in Fungus for Drug Development
Fungi produce a variety of chemical compounds called secondary metabolites. These compounds display a broad range of activities, including fighting off other fungi and bacteria. They also are useful f...
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Nancy Keller, Jin Woo Bok | P130203US01
Technology
Easier, More Flexible Synthesis of Therapeutic and Promising Compounds
Many pharmaceuticals and other biologically active molecules contain chemical sequences called triads that are challenging to prepare in the laboratory. Specifically, triads are three or more contiguo...
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Jennifer Schomaker, Luke Boralsky, John Hershberger, Jared Rigoli, Christopher Adams | P110299US02
Technology
Safer Influenza Vaccine from Replication-Knock Out Virus
Influenza viruses instigate annual global epidemics. The first influenza pandemic in 40 years occurred during the 2009-2010 season, when a novel H1N1 strain emerged and spread worldwide. The United St...
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Yoshihiro Kawaoka, Gabriele Neumann, Makoto Ozawa | P110003US02
Technology
Improved Asymmetric Hydroformylation of Therapeutics Using Novel Bisphosphines
Asymmetric synthesis is important in the pharmaceutical industry because frequently only one optically active isomer, or enantiomer, is therapeutically active. Therefore, it is often desirable to sele...
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Clark Landis, Thomas Clark, Jerzy Klosin | P04447US
Technology
Method for Assessing 3-D Crystal Structures from in Situ Digital Images
Suspension crystallization processes often result in crystals with a wide range of particle sizes. Accurately controlling the distribution of shapes and sizes is a challenge in the pharmaceutica...
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James Rawlings, Nicola Ferrier, Paul Larsen | P06449US
Technology
Universal Nucleotidyltransferases Expand Sugar Substrate Families Available for Glycorandomization
Many of the compounds used in drug discovery by pharmaceutical companies are glycosylated, bacterial secondary metabolites. A glycosylated metabolite consists of a central core structure (aglycon) and...
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Jon Thorson | P07375US
Technology
Neoglycorandomization and Digitoxin Analogs
Many of the compounds used in drug discovery by pharmaceutical companies are glycosylated bacterial secondary metabolites. A glycosylated metabolite consists of a central core structure (aglycon) and ...
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Jon Thorson, Joseph Langenhan | P04455US
Technology
Microfabricated Microbial Growth Assay Method and Apparatus
The growth assay is the simplest, most direct measurement of drug efficacy, and is the primary path for discovering antimicrobial drugs. However, most growth assays use relatively large volumes of liq...
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Daniel van der Weide, Frederick Blattner | P00224US
Technology
Replicating Influenza Mutants with Reduced Sialidase Activity
Influenza A virus possesses two surface spike proteins, hemagglutinin (HA) and neuraminidase (NA). HA binds to sialic acid-containing receptors on host cell surfaces. NA cleaves terminal sialic ...
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Yoshihiro Kawaoka | P01273US