The present invention teaches rapid diversification of vancomycin analogs through glycorandomization and chemoenzymatic strategies resulting in a diverse library of complex natural product architectur...
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The present invention provides methods of producing libraries of compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred...
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Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library ...
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The present invention provides engineered glycosyltransferase enzymes and method for making and using the same possessing an expanded substrate specificity as compared to corresponding non-mutated gly...
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The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the ...
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A viable strategy to enhance the bioavailability of poorly soluble drugs is to use amorphous solids in place of the more commonly used crystalline solids in pharmaceutical formulations. However, amorp...
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Devices, methods and kits are disclosed for preparing and administering less-painful formulations of Botulinum toxin. The devices, methods and kits of the present invention are comprised of or use an ...
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The present invention provides a preparation of botulinum toxin light chain type A or E, wherein the preparation is both catalytically active and soluble. Preferably, the preparation consists essentia...
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Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; ...
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Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; ...
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Methods for derivation, culture, and maturation of small hepatic progenitor cells are described.
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A method of making coated avian egg yolk cores includes providing dried avian egg yolk cores having a diameter of 100 to 1500 micrometers, applying avian egg albumen to the dried avian egg yolk cores ...
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The invention generally relates to arogenate dehydrogenase polynucleotides and methods of using the same. More specifically, the invention relates in part to compositions including arogenate dehydroge...
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The invention generally relates to engineered prephenate dehydrogenases and arogenate dehydrogenases and methods of using the same. More specifically, the invention relates in part to compositions inc...
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The present technology relates generally cyclobutane boronates, including methods of preparation by exposing a mixture of a compound of Formula I in a solvent [Image Omitted] and a catalytic amount o...
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Devices and methods for using changes in the configuration of micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide ...
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The three-dimensional structure of proteins can be studied in solution using various methods of covalent and noncovalent labeling in which the readout is accomplished by mass spectrometry (MS). These ...
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The therapeutic and biochemical properties of proteins including antibodies can be enhanced by custom chemical functionalization that enables modifications, such as small molecule drug conjugation, PE...
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Approximately 20 percent of human proteins – including many of high pharmaceutical relevance – are believed to contain disulfide bonds critical for proper structure and function. However, producin...
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Gram-negative bacterial infections are an ongoing challenge to health care providers worldwide. Detection, treatment and control of such pathogens have gained increasing importance in the context of a...
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Human immunodeficiency virus (HIV) affects over 1.2 million Americans each year, with approximately 50,000 new infections per year. Current treatment includes HIV combination regimens comprising rever...
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Influenza is responsible for hundreds of thousands of deaths worldwide every year. Vaccines can be used to prevent influenza, but traditional methods for producing influenza vaccine are slow and cumbe...
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Fungi produce a variety of chemical compounds called secondary metabolites that possess useful pharmaceutical properties. These compounds are invaluable platforms for developing front-line drugs. They...
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The ability to modulate interactions between proteins is an attractive goal for both research and therapeutic applications. Developing modulating agents using traditional small-molecule approaches is ...
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Fungi produce a variety of chemical compounds called secondary metabolites. These compounds display a broad range of activities, including fighting off other fungi and bacteria. They also are useful f...
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