Wisconsin Alumni Research Foundation

Technology

SOMATIC CELL REPROGRAMMING

The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The inventi...
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James Thomson, Junying Yu | P08167US

Technology

Gene Editing Tool Uses New Enzyme

Genome editing has proven difficult in cells, especially mammalian cells. One way to improve efficiency is to introduce a double-strand break (DSB) in the desired DNA region. These DSBs stimulate cell...
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James Thomson, Zhonggang Hou, Yan Zhang, Rakhi Rajan, Erik Sontheimer, Alfonso Mondragón | P130315US02

Technology

Spatial Control of Signal Transduction

Development of most tissue types involves a complex interplay of multiple growth factors in well defined locations, leading to controlled differentiation of precursor cells into mature, tissue-specifi...
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William Murphy, Gregory Hudalla | P05255US

WARF