Wisconsin Alumni Research Foundation

Technology

Transferrin-Based Lysosome Targeting Degraders

UW researchers have developed a novel means of degrading extracellular proteins as a potential cancer treatment. The researchers recognized that transferrin is a protein ligand that carries iron into ...
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Weiping Tang, Yaxian Zhou | P210432US02

Technology

Nonviral Generation of Genome-Edited CAR T Cells

Use of viral vectors for chimeric antigen receptor (CAR) T cell manufacturing constitutes a bottleneck in the supply chain for biomanufacturing and can be problematic due to: (1) batch-to-batch variab...
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Krishanu Saha, Christian Capitini, Katherine Mueller, Nicole Piscopo, Amritava Saha, Matthew Forsberg, Louise Saraspe | P200184US02

Technology

Metabolic-based Methods For Modulating Gene Expression

This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentrat...
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Thomas Sutula, Avtar Roopra, Barry Schoenike | P05137US

Technology

Alkylphosphocholine Analogs For Multiple Myeloma Imaging And Therapy

The inventors have discovered that certain alkylphosphocholine analogs are preferentially taken up by multiple myeloma tumor cells, as compared to non-tumor cells. The inventors have further demonstra...
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Chorom Pak, Jamey Weichert, Mario Otto, Roberta Marino, Fotios Asimakopoulos, Benjamin Titz, Kevin Kozak | P150207US03

Technology

Peptide-Nanoparticle Conjugates

Described herein is a nanoparticle system including a multivalent nanoparticle core having a plurality of β-hairpin peptides conjugated thereto. Also included are pharmaceutical compositions and meth...
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Seungpyo Hong, Woo-jin Jeong | P200080US02

Technology

Methods Of Controlling Red Blood Cell Production

A method of controlling red blood cell production includes contacting red blood cell precursors with a composition including zinc, a composition including an inhibitor of a zinc exporter protein, or a...
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Emery Bresnick, Nobuyuki Tanimura | P180160US02

Technology

Nanoengineered Surfaces For Cancer Biomarker Capture

Described herein is cancer biomarker, e.g., a vesicle, capture surface that includes a substrate, a first plurality of nanoparticles attached to the substrate; a plurality of bifunctional tethers, whe...
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Seungpyo Hong, Michael Poellmann | P180105US02

WARF